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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 123 for “"Anticancer Agents"”.
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Modified taxols as anticancer agents
Modifications of the potent anticancer agent taxol were carried out in order to gain an understanding of the chemical reactivity of the drug and the factors which contribute to its biological activity. The C-2' and/or the C-7 hydroxyl groups of taxol were substituted with acetyl, ßalanyl, silyl, …
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Liposome drug delivery systems for anticancer agents
… of liposome formulation of an amphiphilic anticancer peptide using the ANTS/DPX leakage assay. The effects of lipid composition on the liposomes' resistance to an amphiphilic cyclic peptide c[KS.S.S.KWL W] were studied by the ANTS/DPX leakage assay. One or more unsaturated acyl chains in …
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South African marine compounds as anticancer agents
… oesophageal cancer, that could be used as lead agents for further development of chemotherapeutic agents. Once our screen was established, we tested a wide range of extracts from southern African marine organisms, supplied by our collaborators from Rhodes University, South Africa. The marine …
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Thiazolidinone-isatin hybrids as multi-target anticancer agents
During the three years of PhD two main projects have been carried out. The projects were focused on the design, synthesis, and characterization of small molecules with antitumoral activity. Cancer is one of major causes of death in the world and, considering its multi-factorial origin it could be …
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STRUCTURE-ACTIVITY RELATIONSHIPS IN FUNCTIONALIZED PLATINUM-ACRIDINE ANTICANCER AGENTS
Since Rosenberg's serendipitous discovery of the cytotoxic properties of cis-diamminedichlor(id)oplatinum(II), better known as cisplatin, the development of new platinum-based chemotherapies with improved activity and reduced toxicity has become a pressing goal. Many second- and third-generation …
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Porphyrin chemistry pertaining to the design of anticancer agents
A limitation of radiotherapy is the lack of selectivity (in term of cell killing) toward tumor cells, especially toward hypoxic tumor cells. Porphyrin drugs used in photodynatnic therapy (PDT) have good selectivity (in term of drug accumulation) toward tumors, but the therapy has a limitation due …
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Synthesis Of 1,4-Triazolyl Combretacoumarins As Potential Anticancer Agents
… to synthesize novel, potential anti-cancer agents called <em>1,4-triazolyl combretacoumarins</em>, by coupling different coumarins and the functionally relevant group of CA-4 i.e, the trimethoxyarene moiety, <em>via</em> a 1,2,3-triazolyl ring using a copper-catalyzed [3 + 2] azide-alkyne …
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SYNTHESIS OF NATURAL-DERIVED POLYPHENOLS AS POTENTIAL ANTICANCER AGENTS
Extracts from plants or other organisms have been used for thousands of years as medicines and today a multitude of researchers continue to be inspired by the astonishing structural variety of natural products to identify potential lead compounds for drug discovery. In the simplest of terms, a …
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Searching for Anticancer Agents and Antimalarial Agents from Madagascar
In our continuing search for biologically active natural products from Madagascar as part of an International Cooperative Biodiversity Group (ICBG) program, a total of four antiproliferative extracts were studied, leading to the isolation of twelve novel compounds with antiproliferative activity …
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SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL ANTIPARASITIC AND ANTICANCER AGENTS
… synthesis and biological evaluation of novel agents for the treatment of VBPDs. The first study explores the potential of nature-inspired hybrids (NIHs), a molecular hybridization approach combining distinct pharmacophores to enhance biological activity and multi-target interactions. The …
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Synthesis and evaluation of novel heterocyclic compounds as anticancer agents
… new drugs from natural resources. Among them are agents that target tubulin,which is a protein found in all eukaryotic cells. This protein is an essential component formitosis and has several different binding sites at which a variety of chemically differentagents interact. These binding sites …
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Supramolecular anticancer agents and their effects on cells and biomolecules
… highly significant in the development of novel anticancer agents. Supramolecular drug agents allow the design and synthesis of a range of molecular architectures. The work in this thesis has built upon previous knowledge on this subject by undertaking novel biological studies on known metal …
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Development of new bioorganometallic metallodendrimers as in vitro anticancer agents
… a profound effect on the use of metal-containing agents in medicine. Despite the successes, the drawbacks of platinum-based therapy, such as drug resistance, toxicity and the emergence of unwanted side effects, have bred a need for effective and novel anticancer agents. Hence, the design and study …
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Developments in the chemistry and nanodelivery of platinum anticancer agents
… One approach is to use non-classical platinum agents such as platinum(IV) prodrugs and monofunctional platinum(II) complexes. The latter, unlike the classical platinum drugs, can only form one bond to the biological target, DNA. Another strategy is to exploit the advantages offered by …
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Novel polyamine based anticancer agents: evaluation of the mode of action.
… to DNA via the major groove and have interesting anticancer properties prompting this study to evaluate their mode of action. All BNIPPs synthesised exert cytotoxicity in colon, breast and leukaemia cancer cell lines. The most active compound, BNIPSpd exhibits 24-hour IC50 values ranging from …
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Development of solid lipid nanoparticles for sustained release of anticancer agents
… used as carriers for the encapsulation of the anticancer drug substance curcumin (CRC), have been investigated. The physicochemical characteristics of the CRC-SLNs were investigated by particle size, zeta potential and stability measurements. In addition transmission electron microscopy was …
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Identification & characterization of natural and synthetic compounds as new anticancer agents
… and Catherine H. Kaschula investigating the anticancer activity of Z-ajoene, a garlic compound. Overall, the main aim of all the my research project was to identify and characterize natural or synthetic compounds as new antineoplastic agents. The results obtained are divided according to the …
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NOVEL STRATEGIES FOR IMPROVING THE PHARMACOLOGICAL PROPERTIES OF PLATINUM-ACRIDINE ANTICANCER AGENTS
Unlike traditional cisplatin-type platinum-based anticancer drugs, platinum-acridine hybrid agents were designed as dual platinating/intercalating DNA-targeted cytotoxics, which are able to cause cancer cell death at low-nanomolar concentrations. Unfortunately, the preclinical development of these …
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DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF NOVEL INDENOISOQUINOLINES AS POTENTIAL ANTICANCER AGENTS
… drugs that target this enzyme. These agents bind to a covalent Top1-DNA cleavage complex intermediate that is formed when Top1 relaxes supercoiled DNA. The effect of this stabilization is that a DNA replication fork can “collide” with the cleavage complex, which produces cytotoxic DNA …
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Doped ZnO nanoparticles in biomedicine: their role as stimuli-responsive anticancer agents
L'abstract è presente nell'allegato / the abstract is in the attachment
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