Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Antibody-mediated immunity"”.
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Human antibody-mediated immunity against infection and parasite fecundity in Schistosoma mansoni and Schistosoma haematobium infection
… of this thesis was to advance understanding of antibody-driven immune responses that partially protect against infection and reduce fecundity in human schistosome infections. The relative contribution of exposure to infection and IgE antibody responses against schistosomes were explored using a …
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Immune responses to polymorphic antigens and protection against severe malaria in Kenyan children
The mechanisms by which individuals acquire immunity to malaria are poorly understood and although antibodies are thought to be central, evidence that specific anti-malarial antibodies are associated with protection from clinical episodes of malaria has been conflicting.<br></br><br></br>I …
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Visualisation and analysis of patterns in serological data using "antibody landscapes"
In this thesis I develop and implement “antibody landscapes”, a method to profile immunity against a pathogen as a function of antigenic differences between a range of strains. Theoretically applicable to any antigenically variable pathogen and measurement of immunity, the work here focusses on …
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Immunological and hematological biomarkers for contaminants in fish-eating birds of the Great Lakes
… laboratory animals. Higher exposure suppresses antibody production and alters white blood cell (WBC) counts. This study investigated whether persistent contaminants alter immunocompetence in Great Lakes herring gulls (Larus argentatus) and Caspian terns (Sterna caspia). It also evaluated the use …
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High throughput measurement of antibody and complement mediated immunity to meningococcal disease
… bactericidal titres of ≥1:4. The importance of antibody and complement mediated immune mechanisms is also emphasised by the increased susceptibility of complement deficient individuals to meningococcal disease. <br></br><br></br> However, the absence of bactericidal activity does not necessarily …
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Site-Specific Labelling of the Flavivirus Envelope Protein using Genetic Code Expansion
… efforts to identify ZIKV-specific B cells for antibody discovery. Additionally, I explored how different labelling approaches might be used to probe dimer stability and the conformational dynamics of the virion. This work lays the foundation for novel approaches using genetic code expansion and …