Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Antibody-Dependent Intracellular Neutralisation"”.
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An investigation into the role of LUBAC and linear ubiquitin chains in antibody dependent intracellular neutralisation
Antibody dependent intracellular neutralisation (ADIN) mediates the rapid proteasomal degradation of antibody-bound viruses. It requires TRIM21, an Fc receptor and E3 ubiquitin ligase that resides in the cytosol. Binding of TRIM21 to the exposed Fc portion of an antibody that is bound to an …
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TRIM21 Mediated Antibody-Dependent Intracellular Immunity
… such as opsonisation, complement activation, antibody-dependent cytotoxicity and receptor blocking. The discovery of TRIM21 as a cytosolic antibody receptor has revolutionised our understanding of humoral immunity and revealed that antibodies can mediate protective immunity inside cells. …