Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Antibody-Dependent Enhancement"”.
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Antibody Dependent Enhancement of Visceral Leishmaniasis
… disease severity hint at the possibility of antibody dependent enhancement of infection (ADE). Herein we explore the possibility of extrinsic ADE as a result of heterologous exposure to <em>L. major</em> and <em>L. infantum in vitro</em>. ELISA was done to verify cross reactivity of <em>L. …
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Characterizing Zika and West Nile virus infection in mast cells and the antibody-dependent enhancement potential mediated by dengue virus antibodies
… serotypes create an immunological paradox called antibody-dependent enhancement (ADE) whereby previously generated DENV antibodies can augment a heterotypic DENV infection. Although antibodies are typically recognized as correlates for immunity, this idiosyncrasy is mechanistically mediated …
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Mathematical Modeling of Dengue Viral Infection
… The current hypothesis for this phenomenon is antibody-dependent enhancement, where strain-specific antibodies from the primary infection enhance infection by a heterologous serotype. To determine the mechanisms responsible for the increase in disease severity, we develop mathematical models of …
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Immunoepidemiological Modeling of Dengue Viral Infection
… severity during secondary infections are antibody dependent enhancement and original antigenic sin. Antibody dependent enhancement suggests that long-lived antibodies from primary infection remain during secondary infection but do not neutralize the virus. Original antigenic sin proposes …
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INVESTIGATING THE ROLE OF DENGUE-SPECIFIC IMMUNITY IN PROTECTION AND DISEASE USING SYMPTOMATIC MOUSE MODELS
… mouse models recapitulate the phenomenon of antibody-dependent enhancement (ADE): mice born to DENV1-immune mothers developed enhanced disease upon DENV2 infection. Utilising these models, we investigated the role of dengue-specific immunity in dengue disease. Firstly, we investigated the …
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Studies on the antibody repertoire in a Dengue virus immune subject and isolation of neutralizing antibodies by phage display technology
… with other serotype(s) via a mechanism known as Antibody-Dependent Enhancement (ADE) by cross-reactive, non-neutralizing antibodies. Previous studies using mouse mAbs demonstrated that the Ectodomain III (EDIII) in the E protein of DENV is the primary target of the most potent neutralizing …
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Insights from serological surveillance in infectious disease epidemiology
… methods to maximize inferences from IgG antibody data and investigate epidemiological questions relating to the transmission and immune dynamics of human pathogens. Using SARS-CoV-2 seroprevalence studies and age-specific COVID-19 death data, I refined estimates of SARS-CoV-2 infection …
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Drivers of Dengue Within-Host Dynamics and Virulence Evolution
… there is statistical support for the theory of antibody dependent enhancement in the development of severe disease in secondary dengue infections and that there is statistical support for serotype-specific differences in viral infectivity rates, with infectivity rates of DENV-2 and DENV-3 …