Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Antibody therapeutics"”.
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Optimisation of CHO Cell Line Development Using Hybrid Modelling for Antibody Therapeutics
… particularly for personalised medicines and biotherapeutics, which hold the potential to be the safest and most effective therapeutic of all [1, 2]. Herein I propose a novel method for optimising upstream biopharmaceutical process scaling up using a data-driven hybrid model that integrates …
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Development of polymeric nanoparticulate formulation encapsulating protein molecules following hydrophobic ion pairing complexation
… been employed to enable sustained delivery of antibody therapeutics by nanoparticulate based dosage forms. However, development of sustained release nanoparticulate based dosage form for protein therapeutics represents a real challenge to scientists. These protein molecules are prone to …
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Machine Aided Biological Discovery and Design
… discovery campaigns to identify nonspecific antibody therapeutics in large candidate pools. We show that this approach bypasses and outperforms costly combinatorial affinity selection experiments and allows the use of only single-target selection data to identify pairwise nonspecificity. …
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Expanding the Scope of T3 DNA Ligase-Catalyzed Oligonucleotide Polymerizations (T3-LOOPER)
… are currently the gold standard in the field of therapeutics but are quite costly and chemically unstable. Nucleic acid polymers can mimic antibody therapeutics but are more cost effective to produce, can reversibly denature, and have a high synthesis reproducibility. These polymers are called …
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"Chasing a ghost": Addressing the opalescence/aggregation relationship of an IgG 1 antibody
… relationship of an IgG 1 therapeutic antibody under a variety of conditions. The opalescence characteristics of three antibodies, Mab 1, 2 and 3, were examined as a function of salt dependence, protein concentration and temperature, using a variety of biophysical techniques. The high …
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Engineering aglycosylated antibody variants with immune effector functions
… antibodies have emerged as a promising class of therapeutics for the treatment of human disease, and in particular human cancer. While multiple mechanisms contribute to antibody efficacy, the engagement and activation of immune effector cells - mediated by the interaction of the conserved Fc …
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Collagen Anchoring Agonist Antibodies for Cancer Immunotherapy
… particularly CD8⁺ T cells. Translation of these therapeutics into the clinic has been hampered by severe, sometimes fatal, on-target, off-tumor toxicities. Thus, the field at large has shifted focus to developing agonist antibodies with tumor restricted activity. To that end, we developed …
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NOVEL PEPTOID TARGETING CELL SURFACE VIMENTIN FOR LUNG CANCER TREATMENT
… In comparison to conventional peptide and antibody therapeutics, peptoids exhibit improved serum and chemical stability, tissue and cell permeability, and reduced immunogenicity. The economical and straightforward synthesis of peptoids allows the development of peptoid libraries with …
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Developing Magnetic Resonance Based Analytics to Support Continuous Bioprocess
… application. Bovine serum albumin and an IgG1 antibody are used as model extracellular proteins. Due to the difficulties imposed by the large size of the proteins and the intense resonances produced by their media solutions, the experimental techniques require optimization of the NMR pulse …