Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Antibody neutralisation"”.
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Role of envelope compactness and glycosylation in HIV-1 resistance to neutralising antibody responses
… the mechanisms used by HIV-1 to evade antibody neutralisation may contribute to the design of a high-coverage vaccine. This thesis explores the mechanism used by a Tier 3 virus leading to its high antibody neutralisation resistance phenotype. This thesis also describes how the glycans …
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Expression and characterisation of biopharmaceuticals in heterologous expression systems
… relevant anti-HIV full-size IgG1/kappa antibody, (BY-2)2F5, and a soluble form of the high-affinity receptor for human IgG, Fc-gamma-RI (CD64), were successfully established and optimised for heterologous expression in plants, bacteria and mammalian. The first aim of this thesis was the …
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Responding to an Evolving Pandemic: Characterisation of Emerging Evolving Viruses and Population Immunity by the Example of SARS-CoV-2
… distant SARS-CoV-2 strains on the breadth of antibody neutralisation, as well as results from a controlled clinical trial that contributed to the first SARS-CoV-2 vaccine strain update. Mapping immunity after the vaccine strain update together with variant circulation at the time revealed the …