Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Antibody mediated rejection"”.
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Study of Physiologic and Immunologic Incompatibilities of Pig to Human Transplantation
… Second, immunologic incompatibilities due to antibody recognition of antigens resulting in antibody-mediated rejection were studied. Identification of relevant targets was systematically approached through evaluation of a known xenoantigenic protein fibronectin from genetically modified pigs. …
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Outcomes of renal transplantation in patients with lupus nephritis: a single centre study in Cape Town
… patient (6.7%) who developed class V LN. Graft rejection was diagnosed in 10/15 cases (66.7%) with types of rejection noted to be acute cellular rejection in 6/15 (40%), antibody mediated rejection 1/15 (6.7%) and chronic rejection in 3/15 (20%). ESRD occurred in 3 patients (20%) with causes …
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Characterizing the Immunogenicity of Islet-like Cells derived from HLA-edited Human Pluripotent Stem Cells
… of stem cell-derived islets to allorejection. I first describe methods to improve differentiation into cells bearing the successive phenotypes of primitive streak, definitive endoderm, and pancreatic progenitors. I next explore mechanisms that regulate the endocrine composition of …
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Characterisation of Alloantibody-Human Leukocyte Antigen Interactions to Improve Immunological Risk Assessment in Solid Organ Transplantation
Antibody mediated rejection remains a major challenge in solid organ transplantation, where the development of immunoassays for characterisation a recipient’s donor HLA-specific antibodies has revolutionised the field of solid organ transplantation. These immunoassays are essential for patient …
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The Impact of Ventricular Assist Device Prior to Transplantation on Morphological Parameters in Cardiac Allografts /// Въздействие на вентрикуларните помощни устройства преди трансплантация върху морфологичните параметри при сърдечните алографи
… as MCS patients show a higher frequency of antibody-mediated rejection (AMR) episodes. We aimed to analyze the effects of MCS on cardiac AMR with regards to capillary C3d and C4d depositions. Regarding the functional parameters, both acute cellular rejection (ACR) and an increase of …
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The spectrum of HIV-related kidney disease in South Africa
… we report a high cumulative incidence of rejection episodes, with 36% showing T-cell-mediated rejection or antibody-mediated rejection (ABMR). Non-rejection findings included fibrosis, pyelonephritis, and calcineurin toxicity. Features of HIVAN were identified in nine patients. ABMR …
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Humoral alloimmunity in cardiac allograft rejection
… presents the initial characterisation of alloantibody mediated rejection in a murine heart transplant model, with particular focus on the impact of the different phases of the humoral alloimmune response (follicular or germinal centre) on graft rejection.
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Antibody-omics for biomarker discovery in vaccinology and infectious diseases
… domain (Fc). While traditional methods of antibody profiling have successfully applied top-down approaches for mainly Fab analysis indicative of overall isotype titer, the Fc interactions between adaptive and innate immunity remain overlooked. As a result, a poorly defined antibody profile …
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Investigation of novel therapeutic strategies in B cell and antibody mediated disease
… differentiated B cells are responsible for antibody generation, a key component of adaptive immunity. IgG antibodies play an important role in defence against infection but can be pathogenic in some autoimmune diseases and in solid organ transplantation. In addition to antibody generation, …
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Renal allograft biopsies at Groote Schuur Hospital: a histopathologic descriptive study with molecular insights
… treatment for end-stage kidney disease. Immune-mediated rejection remains a barrier to success. It is diagnosed through the Banff classification, which incorporates histopathology and biomarkers (C4d/donor specific antibodies (DSA)). In resource-limited settings, DSA testing can be challenging, …