Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Antibody design"”.
-
Molecular modeling and simulations of viruses: structure, dynamics and antibody design
… recently integrated MD simulation into a de novo antibody design program to assess the binding and thermal stabilities of the designed antibodies and to identify antibodies with high binding affinity. We first investigated a retrovirus capsid in its immature, non-infectious state. For a retrovirus …
-
Efficient New Computational Protein Design Algorithms, with Applications to Drug Resistance Prediction and HIV Antibody Design
… of proteins than is currently available. Protein design aims to explore the space of possible proteins in order to create new proteins with novel or improved biological functions. Two key challenges in protein design, however, are the astronomically large number of possible protein sequences, …
-
Rational Design and Application of Antibodies for Amylin and Amyloid Beta
… and affinity for targets. However, traditional antibody discovery methods often fail to produce antibodies with desirable properties such as epitope selectivity, conformational stability, and solubility. Computational antibody design methods combining epitope targeting, solubility calculation …
-
Fine-tuning Boltz for Antibody-Antigen Binding Prediction
Accurate prediction of antibody-antigen binding is a central challenge in computational immunology. Its direct implication for therapeutic antibody design and vaccine development has made it one of the most rapidly growing fields. Recent advances in protein language models and structure prediction …
-
Quantitative analysis of perivascular antibody distribution in solid tumors
… as a function of quantitative parameters of the antibody and associated antigen. A novel experimental system to quantitatively determine bound antibody levels, antigen levels, and blood vessel localization on a microscopic scale throughout entire tumor cross sections has been developed. This …
-
Molecular Mechanisms of Lymphocyte Activation - Please Mind the Gap
… of lymphocyte activation and motivates antibody design for immunotherapy as well as close-to-physiological signalling studies.
-
On Epitope-Paratope Interactions of Emerging to Endemic Viruses
… antibodies that bind virus epitopes via the antibody’s paratope domain in an epitope-paratope interaction (EPI). EPIs are key aspects of the dynamic interplay between the virus and the host immune response to neutralize the virus. Studying EPIs enables us to better understand viral …
-
Rational Design of Antibodies against Tau and Alpha-Synuclein
… In earlier studies, an oligomer-specific antibody against Abeta was created to detect and quantify oligomers by applying a rational antibody design approach known as the cascade method. Here, we used this method to design a library of antibodies (DesAbs) systematically covering the length …