Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Antibody Secreting Plasma Cells"”.
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Early Growth Response Protein 2 (EGR2) regulation of B cell differentiation in lupus-prone mice
… treatment. It involves abnormal activation of B cells, which produce pathogenic autoantibodies that contribute to inflammation and tissue damage in multiple organs. Therapeutic depletion of B cells in human lupus patients had mixed success due to the complex heterogeneity of B cell subsets, …
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REDOX REGULATION OF B CELL ACTIVATION AND THE ANTI-VIRAL HUMORAL IMMUNE RESPONSE
… postinfection, splenic LCMV specific IgM and IgG antibody secreting cells (ASC) were 22- and 457-fold lower in MnTBAP-treated mice, respectively. However, by day 38 post infection, LCMV specific IgG ASC were decreased 5-fold in the bone marrow. In contrast, the number of LCMV specific memory B …
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Age-associated Changes in the Germinal Centre Response Upon Vaccination
… vaccination through the production of memory B cells and long-lived antibody-secreting plasma cells. However, the GC response deteriorates with age contributing to poor humoral immunity after vaccination and therefore to increased susceptibility to infections in older individuals. I aimed to …
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STUDIES OF B CELL DEVELOPMENT AND V(D)J RECOMBINATION
… from the final pool of antigen responding B cells that ultimately give rise to antibody secreting plasma cells. Understanding the complexity of the recombination processes and the diversity of the resulting antibody repertoire has been a major focus of academic and industrial research alike. …
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Recall Germinal Center and Antibody Responses
… to viruses or their antigens elicits anamnestic antibody responses that produce antibodies that are of greater magnitude and affinity compared to those induced after primary exposure to antigen.The anamnestic nature of the response is a result of the recall of memory B cells (MBCs) that have …