Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Antibody Recognition"”.
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Design and characterization of plasmonic nanoprobes and interparticle interactions for surface enhanced raman scattering and biomolecular detection
… include dye-mediated π–π stacking, antigen-antibody recognition, and DNA complementary binding. These molecular and biomolecular interactions lead to the formation of interparticle “hot-spot” in terms of plasmonic coupling of the nanoparticles responsible for the surface enhanced Raman …
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Study of Physiologic and Immunologic Incompatibilities of Pig to Human Transplantation
… involved with platelet homeostasis. Carbohydrate recognition domains of receptors responsible for platelet clearance Macrophage antigen complex-1 (CD11b/CD18) and Asialoglycoprotein receptor 1 in pigs were found to be different from those in humans, further supporting the involvement of platelet …
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Study of the Immune Correlates of Protection in Rhesus Macaques Vaccinated against Simian Immunodeficiency Virus
… phase. Statistical analyses support serum IgG antibody recognition of the V2 region of viral gp120 as a mechanism of protection from acquisition. One hypothesis is that antibodies to this region might block the interaction with the integrin $\alpha4\beta7$, which protrudes from the surface of …
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Nanoscale protein analysis utilizing capillary electrophoresis and laser-induced fluorescence detection
… the extent of labeling and modification site. Antibody recognition of this fluorescent analog was evaluated using CE-LIF, illustrating the clinical utility of this diagnostic reagent. In addition to the above CE-LIF approaches, a fourth capillary electrophoretic tool is provided for the …
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Biochemical characterisation of a novel vaccine candidate against Trypanosoma vivax, the cell surface glycoprotein IFX
… purification, biochemical characterisation and antibody recognition of a recently discovered cell surface glycoprotein and vaccine candidate, Invariant Flagellum Antigen from Trypanosoma vivax (IFX) from the kinetoplastid parasite Trypanosoma vivax. African trypanosomes are unicellular protozoan …
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Integrative approaches to decipher influenza evolution, antibody responses, and AI-driven specificity prediction
… viral proteins; (2) large-scale analysis of antibody responses to SARS-CoV-2 and influenza; and (3) development of AI models to predict antibody specificity. Chapter 1 introduces the rapid advancement of high-throughput and AI methodologies for studying immune responses and viral evolution. …
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Characterization of a Novel Sensing Mechanism Governing Antigenic Variation in P. Falciparum
… ability to sense environmental changes. After recognition of a pathogen, activated macrophages modify their microenvironments in various ways. I next tested the effect of two of these immune responses, depletion of amino acids and release of polyamines, on var expression of parasites in vitro. …
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Enhanced Proteomic Methods to Decipher How the Novel Protein SNED1 Modulates the Extracellular Matrix
… of SNED1 in-situ. I adapted biotinylation by antibody recognition to the ECM samples, and have optimized the labeling reaction to experimentally identify an ECM interactome for the first time. I propose that the methods I have developed can become the next pipeline of ECM proteomics. The …