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Showing 1 to 15 of 15 for “"Antibodies, Monoclonal"”.
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New Approaches to the Development of Peptoid Vaccines
… elicit the production of broadly protective antibodies against conserved epitopes. However, the epitopes that elicit these antibodies are often not immunodominant and even when they are, characterizing and synthesizing them can be difficult, particularly if they are conformational. The …
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Anti-Angiogenic Therapy in Non-Small Cell Lung Cancer: Characterizing a New Therapy and Investigating Potential Mechanisms of Resistance
… (Avastin®, Genentech/Roche), a humanized monoclonal antibody that recognizes human VEGF and blocks VEGF from binding to VEGF receptor (VEGFR) 1 and 2, was the first anti-angiogenic drug approved by the United States Food and Drug Administration for the treatment of cancer and remains the …
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NK Cell Function and Tumor Resistance in Mice Transgenic for Antibody to NK Inhibitory Receptors
… Among proposed immunotherapeutic approaches, monoclonal antibody treatments have shown the best efficacy in human clinical trials. NK cells, cytolytic effector cells of the innate immune system, are implicated in tumor surveillance. Inhibitory Ly49 receptors determine the specificity of murine …
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Understanding the Mechanism of Action of Rituximab in the Reversal of Multidrug Resistance in a Non-Hodgkins Lymphoma Cell Line
… been previously demonstrated that an anti-CD20 monoclonal antibody (MAb) can reverse MDR in B lymphoma cells in vitro. However, the mechanisms underlying this effect are unknown. A recent study showed that anti-CD20 MAbs could induce rapid redistribution of CD20 into a detergent-insoluble …
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Chimeric ANTI-CD19 Monoclonal Antibodies for the Treatment of Precursor B Cell Acute Lymphoblastic Leukemia
… immunotherapies for them are based on anti-CD20 monoclonal antibodies (MAbs). However, CD20 is not expressed on precursor B cell acute lymphoblastic leukemia (pre-B ALL), and CD20 expression is often lost following anti-CD20 immunotherapy. CD19 is a pan B cell membrane antigen that is restricted …
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The Mechanism of cGAMP Induced Antitumor Effect and Its Application in Treating Cancer and Antibody Generation
… conjugate (ADC) that links a STING agonist to antibodies targeting EGFR, prevalent in many cancers. This STING ADC activates various immune cells and promotes macrophage polarization within tumors. Chapter Five utilizes cGAMP as an adjuvant to enhance the generation of SARS-CoV-2 antibodies, in …
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Potentiating Antibody Therapy by Targeting Complement on Cancer Cells
BACKGROUND: Monoclonal antibodies (mAb) are a key component of treatment regimens for hematologic malignancies, but mAb-induced antigen loss on tumor cells can lead to treatment failure. Loss of cell surface CD20 can occur in the treatment of lymphoid malignancies with anti-CD20 antibodies (mAbs) …
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An Immunochemical Analysis of Alcoholic Hyaline and its Relationship to Keratin Intermediate Filaments
… means, using polyclonal as well as monoclonal antibodies. Enzyme-linked immunosorbent assays (ELISAs) were employed, as well as "immunoblotting" and immunocytochemical techniques. HCK was isolated using Triton X-100 and "high-salt” buffers and exhibited seven major polypeptide bands …
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The Production and Characterization of a Monoclonal Antibody to a Naturally Occurring Aminomalonic Acid Epitope and a Comparison with an Antibody to a Synthetically Derived Aminomalonic Acid Epitope
… step in the study of blocking metastasis by a monoclonal antibody. The long range goal of this line of research is to study a novel mechanism for the blocking of tumor metastasis in general and prostatic cancer metastasis in particular. The problem that this addresses is the growing number of …
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In Vitro Evaluation of Cancer Patient Immune Responses Following Infusion of Radiolabeled Murine Monoclonal Antibody
<p>Several monoclonal antibody (MAb) types derived from mice have been developed specifically for the use of targeting human tumors. The specificity of these murine MAb’s for their respective tumor antigens is very high making them potentially good immunotherapeutic agents for cancer treatment and …
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UNDERSTANDING THE MOLECULAR BASIS OF CELL DEATH MEDIATED BY ONCOSIS-INDUCING CYTOTOXIC ANTIBODIES
MONOCLONAL ANTIBODIES (MABS) A2, B3 AND B8, RAISED AGAINST HUMAN EMBRYONIC STEM CELLS, WERE FOUND TO SPECIFICALLY INDUCE ONCOSIS IN VARIOUS CANCER CELL LINES BUT NOT TO CORRESPONDING NORMAL CELL LINES. CHARACTERIZATION REVEALED THAT THESE MABS RECOGNIZED A GLYCAN MOIETY STRUCTURALLY RELATED TO …
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Tactical planning optimization for campaign scheduling of active pharmaceutical ingredient production based on monoclonal antibodies
Monoclonal Antibodies (mAb's) are the fastest growing segment in the biopharmaceutical industry. They are used today as therapeutics and diagnostics for several medical applications, including various types of cancer, rheumatoid arthritis, psoriasis, severe asthma macular degeneration, multiple …
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Exosomal Survivin-T34A: A Novel, Potential Cancer Therapeutic
<p>Pancreatic cancer is the fourth most common cause of cancer fatality in American men and women with a less than 5% survival rate. Currently, if diagnosed early, surgical resection remains the only viable cure. However, only 20% of pancreatic cancer patients meet these criteria. It is therefore …
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Transdermal delivery of heavy chain only antibody binding domains using hydrogel-forming microarray patches
Since the licensing of the first monoclonal antibody (mAb) over 30 years ago, the mAb industry has expanded exponentially, with six of the top 10 blockbuster drugs in 2018 being antibody-based. However, rather than resting on their laurels, drug developers have continued to innovate. This has led …
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Modeling approaches to characterize the disposition of monoclonal antibodies
Monoclonal antibodies (mAbs) are engineered immunoglobulins G (IgG) used for more than 20 years as targeted therapy in oncology, infectious diseases and (auto-)immune disorders. Their protein nature greatly influences their pharmacokinetics (PK), presenting typical linear and non-linear behaviors. …