Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Antibiotic tolerance"”.
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Antibiotic Tolerance and Heteroresistance: Associated Fitness Costs and Potential in Evading Antibiotic Killing
… S. pneumoniae was susceptible to almost all antibiotics. Since then, this pathogen has gained resistance to a variety of antibiotic treatments, including beta-lactams, macrolides, and fluoroquinolones.</p> <p>In the first chapter, we focused on fluoroquinolone resistance in S. pneumoniae. …
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Approaches to investigating antibiotic efficacy and discovery of treatment strategies against antibiotic tolerance
While it is widely understood that antibiotic resistance is challenging the efficacy of our antibiotic therapies, there is a growing appreciation for the clinical importance of other ways that bacteria can survive antibiotic treatment. In particular, antibiotic tolerance describes a set of …
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Acquisition of an Antibiotic Tolerant Phenotype in Enterobacter cloacae and Klebsiella pneumoniae through Antibiotic-Induced Metabolic Regulation
… and have been associated with the spread of antibiotic resistance. These organisms can enter a physiological state that allows a fraction of each population to survive antibiotic exposure at concentrations above what is necessary to treat most of the population. Because most of the population …
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Exploring the Physiological Role of Vibrio fischeri PepN
… strain in response to salinity, acidity, and antibiotic tolerance. This study has provided a foundation for future work on identifying a putative role for V. fischeri PepN in regulating stress response.</p>
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Differential Expression Analysis of Type II Toxin-Antitoxin Genes of Pseudomonas aeruginosa PAO1 under Different Environmental Conditions
… is considered as one of the primary reason for antibiotic tolerance besides genetically acquired antibiotic resistance. Persisters are the subpopulation of a clonal bacterial population, which can survive environmental extremes and become invulnerable to stresses due to limited metabolic …
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Exploring and enhancing context-dependent beta-lactam antibiotic efficacy
Antibiotics, such as beta-lactams, are essential medical tools for the treatment of bacterial infections. Unfortunately, clinical treatment efficacy is declining over time as bacteria adapt to and evade antibiotic treatment through mechanisms called antibiotic resistance, tolerance, and …
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Investigating The Single Cell Heterogeneity and Physiological Impact of Mistranslation
… a population and contribute to increased stress tolerance in a subpopulation of cells. In comparison to transcription, the influence of translation on single cells is unclear. In this study, my collaborators and I have developed a dual-fluorescence reporter that allows us to measure the …
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Cystic fibrosis and the gut microbiota
… CF gut microbiota for a putative probiotic with antibiotic tolerance, resulting in identification of L. plantarum 9_S2. In addition, the gut microbiota composition and function were examined following treatment with Cystic Fibrosis transmembrane conductance regulator (CFTR) modulation therapy, …
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Controlling Pseudomonas aeruginosa Persister Cells by Human Granulocyte Macrophage Colony-Stimulating Factor
… These mechanisms allow bacteria to exhibit antibiotic tolerance and relapse to an active virulent state when the antibiotic treatments are discontinued. During bacterial invasions, the host immune cells secrete special signaling proteins, known as cytokines which orchestrate events leading …
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Targeting infectious species by Structure-guided Fragment-based Drug Discovery and in silico approach
We are living in a post-antibiotic era in which several human pathogens have developed multidrug resistance and few new antibiotics are being discovered. In addition to the challenge of the emergence of antibiotic resistance, the bacterial population also harbours mechanisms that increase …
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A mechanistic understanding of the postantibiotic effect and treatment strategies
<p>Although antibiotics have proven to be one of the great achievements of modern medicine, their efficacy has dramatically decreased over the past several decades. This is due, in part, to the rapid pace of natural bacterial evolution, but also to the overuse and misuse of antibiotics in general. …
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Redefining gene distributions in K. pneumoniae and E. coli using large public datasets
… and virulence genes and to contribute to antibiotic tolerance. The analysis on TA systems in K. pneumoniae revealed new insights regarding the distribution TA systems in the species. These insights were then expanded to examine the distribution of all genes of the E. coli gene pool in a …
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Controlling Bacterial Persister Cells and Biofilms by Synthetic Brominated Furanones
<p>Bacteria are well known to obtain tolerance to antibiotics by forming multicellular structures, known as biofilms, and by entering dormancy and forming persister cells. Both mechanisms allow bacteria to tolerate antibiotics at concentrations hundreds to thousands of times higher than the lethal …
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Understanding Control of Metabolite Dynamics and Heterogeneity
… which maintains a non-growing state that confers tolerance to antimicrobial compounds. Taken together, this work provides deeper understanding of the design principles for the control of metabolite dynamics and heterogeneity for applications in metabolic engineering and synthetic biology.</p>
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Secondary ion mass spectrometry imaging of surface-bound microbial communities
… the spatiochemical response of P. aeruginosa to antibiotic exposure was examined with SIMS imaging, CRM, and a number of traditional microbiology techniques. This study showed that P. aeruginosa swarms migrate away from the antibiotic source and increase their production of several alkyl …