Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Antibiotic target"”.
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An Investigation of Bacterial Ribonucleases as an Antibiotic Target
<p>Antibiotics have been commonly used in medical practice for over 40 years. However, the misuse and overuse of current antibiotics is thought to be the primary cause for the increase in antibiotic resistance.</p><p>Many current antibiotics target the bacterial ribosome. Antibiotics such as …
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Structural and biochemical investigations into the Neisseria gonorrhoeae ribonucleotide reductase
… states, makes RNR both a current anticancer drug target and a promising antibiotic target. Differences in composition of inactive states between human and some bacterial RNRs further elevates RNR as a potential selective antibiotic target. This thesis structurally and biochemically characterizes …
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Analogues of Nitrofuran Antibiotics are Potent GroEL/ES Pro-drug Inhibitors with Efficacy against Enterococcus Faecium, Staphylococcus Aureus, and Escherichia Coli
… human health, capable of developing significant antibiotic resistance. These pathogens contribute to over 2 million annual infections and ~23,000 annual deaths in the U.S. In addition, various strains of E. coli have also shown a proclivity to develop resistance against common drug classes. The …
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Exploring Potential Drug Target Sites In The Ribosome Using Cisplatin And Its Analogues
… sites can potentially be utilized as a new target sites in the design of structure-based antibiotics. When charge and size of the complex were changed, the binding preference was altered. In addition to the expected consecutive Gs, cisplatin analogues preferentially targeted AG sites on loop …