Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 541 for “"Antibiotic resistance"”.
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Tracking Antibiotic Resistance throughout Agroecosystems
Widespread use of antibiotics in livestock production can result in the dissemination of bacteria carrying antibiotic resistance genes (ARGs) to the broader environment. Within agroecosystems, ARGs can pose a risk to livestock handlers, farmers, and ultimately consumers. The overall goals of this …
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Antibiotic resistance in the gut microbiota
Antibiotic resistance is an increasing threat to our ability to treat infectious diseases. Thus, understanding the effects of antibiotics on the gut microbiota, as well as the potential for such populations to act as a reservoir for resistance genes, is imperative. This thesis set out to …
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Mobilome and antibiotic resistance in Acinetobacter baumannii
… infections with a remarkable ability to develop resistance to multiple antibiotics (multidrug-resistance, MDR) which makes it a highly troublesome pathogen in many hospitals around the world. Third-generation cephalosporins (such as ceftazidime) and carbapenems (such as imipenem and meropenem) …
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Antibiotic Resistance Genes in Marquette County Michigan's Wastewater
<p>Antibiotic-resistant bacteria evade standard treatments, increasing disease severity, patient morbidity, and mortality. Following exposure to an antibiotic, resistant bacteria survive and pass antibiotic resistance genes (ARGs) to their progeny cells. Few ARG studies have utilized wastewater …
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Antibiotic Resistance: Multi-Drug Profiles and Genetic Determinants.
… multi-drug profile consisting of 11 β-lactam antibiotics was performed on the 41 <em>M. catarrhalis</em> isolates. Kirby Bauer disk assays were performed for 7 cephalosporin and 4 non-cephalosporin antibiotics.</p> <p>In summary, 2 observations implicate more complex resistance determinants …
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Detection of antibiotic resistance genes in gardening composts
… used for gardening. To evaluate the risk of antibiotic resistance and potential pathogens in composts, two homemade composts, eight commercially available composts, and one immature swine mortality compost were collected and analyzed by high-throughput quantitative polymerase chain reaction …
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Integrons and integron-related antibiotic resistance in acinetobacter
… receiving intensive care and comprehensive antibiotic resistance of these organisms hampers treatment of infections due to A.baumannii. The molecular basis of antibiotic resistance in A.baumannii has not been extensively investigated. A few studies have demonstrated the role of plasmids and …
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Cooperative behaviors in the evolution of antibiotic resistance
… and modeling, I explored how inactivation of antibiotics by antibiotic-resistant bacteria affects the evolution of antibiotic resistance in two simple microbial communities. First, I examined the interaction between a resistant strain and a sensitive strain of the bacteria Escherichia coli in …
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Combating biofilms and antibiotic resistance using synthetic biology
… source of morbidity and mortality. Biofilms and antibiotic resistance pose challenges to our future ability to treat bacterial diseases with antibiotics (1). Bacteria frequently live in biofilms, which are surface-associated communities encased in a hydrated extracellular polymeric substances …
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Recovery of Antibiotic Resistance Genes From Agricultural Runoff
The reduced capacity of antibiotics to treat infections is one of the greatest health concerns that society faces. There is substantial evidence that links this reduced capacity with the widespread use of antibiotics in livestock production. Livestock can act as reservoirs of antibiotic resistance …
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Excretion of Antibiotic Resistance Genes by Dairy Calves
… used to evaluate the effect of milk replacer antibiotics on abundance of selected antibiotic resistance genes (ARG) in the feces. Calves were blocked by breed, gender, and birth order, and assigned to one of three treatments at birth. Treatments were control (containing no antibiotics in the …
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The Biological Burden of Antibiotic Resistance in Staphylococcus aureus
<p>Antibiotic resistance is a major problem. Resistance is often mediated by genes on bacterial plasmids and dissemination of resistance is commonly achieved by plasmid transfer. The mechanisms of resistance that are presently understood suggest that resistance is energetically costly. If this is …
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Modeling the Dissemination of Antibiotic Resistance in Aquatic Environments
The emergence of antibiotic resistance in riverine systems has become a growing issue worldwide. The use of watershed-scale models is popular with many other water quality issues but not in the case of antibiotic resistance. In this study, we introduce a watershed-scale bacteria fate and transport …
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Computational Tools for Annotating Antibiotic Resistance in Metagenomic Data
… for metagenomic data. The identification of antibiotic resistance genes (ARGs) from metagenomic data is carried out by searches against curated databases producing a high rate of false negatives. Thus, I developed DeepARG, a deep learning approach that uses the distribution of sequence …
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Metagenomics-Based Environmental Monitoring of Antibiotic Resistance: Towards Standardization
Antibiotic resistance (AR) is a critical and looming threat to human health that requires action across the One Health continuum (humans, animals, environment). Coordinated surveillance within the environmental sector is largely underdeveloped in current National Action Plans to combat the spread …
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Bacterial Outer Membrane Vesicles. Mediators of virulence and antibiotic resistance.
… respiratory tract are mediators of virulence and antibiotic resistance, interacting with host cells as well as other bacterial species found in polymicrobial infections.
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Detection and characterization of antibiotic resistance plasmids in Cheney biosolids
… bacteria are selected because of the presence of antibiotics and their byproducts. These resistant bacteria are more likely to transfer resistance genes to other bacteria. In the current study, we examined Cheney biosolids for the presence of drug resistant bacteria and the role of these bacteria …
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