Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Antibiotic conjugates"”.
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The synthesis and biological evaluation of a library of autoinducer-antibiotic conjugates
Microbial resistance to antibiotics is a serious global health threat, and the discovery of new, safe and effective antibiotics is required urgently. A new class of antibiotics, namely sideophore-antibiotic conjugates, has shown promise in initial studies. Siderophores are used by bacteria for iron …
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Cargo delivery into gram-negative bacteria via enterobactin uptake machinery
… and chemistry of siderophores and siderophore conjugates. Siderophores are small-molecule iron chelators synthesized by bacteria for scavenging iron from the environment. Their iron-binding properties, structures, transport machineries and biosynthesis are discussed with a focus on enterobactin …
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Siderophore-Based Drug Repurposing of Platinum Anticancer Agents as Targeted Antibiotics and Investigation of Pt-Induced DNA Damage in Gram-Negative Bacteria
… exacerbated by the overuse of broad-spectrum antibiotics, resulting in adverse consequences such as the rapid emergence and spread of antibiotic resistance. Additionally, the use of broad-spectrum antibiotics disrupts the human microbiota, potentially leading to the onset of diseases …
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Improving antibiotic therapy for Mycobacterium tuberculosis
… urgent need to understand the mechanisms behind antibiotic treatment failure and to develop new and improved therapeutic strategies. The aim of my thesis is to address these issues by exploring strategies to improve drug delivery and optimise antibiotic interactions within treatment regimens to …