Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Antibiotic compounds"”.
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Discovery and Optimization of a Family of Naturally Encoded Antibiotic Compounds that Evade Antibiotic
… health emergency. To combat this,novel potent antibiotics with unique modes of action are required. The classic arsenal of antibiotics used in clinical settings are largely natural products discovered by bulk fermentation of bacterial species isolates that are then extracted and purified to …
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Application of chitosan-carbon nanotube hydrogel beads composite in the removal of antibiotic compounds and perfluoroalkyl substances from aqueous solution
This thesis is submitted for the fulfilment of academic requirements for the degree of Doctor of Engineering: Chemical Engineering, Durban University of Technology, Durban, South Africa, 2025.
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Use of solution-state nuclear magnetic resonance spectroscopy to determine the structures of medicinally relevant peptides and proteins
… all modified to their mature form by a single lantibiotic synthetase. Next was the two peptide lantibiotic cytolysin, unique among bacteriocins in that it has hemolytic activity in addition to bactericidal activity. Nisin, the prototypical lantibiotic, was studied in the context of the immunity …
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The influence of positively charged nitrogen species on compound accumulation and activity in gram-negative bacteria
… FDA approvals for new classes of broad-spectrum antibiotics in over 50 years, these infections constitute a major threat to human health. A significant challenge is the inability of most compounds to accumulate in Gram-negative bacteria. Recently developed predictive guidelines called the eNTRy …
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Structure and function analysis of the natural product plantazolicin, a bacillus anthracis-specific antibiotic
… been the scaffolds for the majority of approved antibiotic compounds. In this dissertation, I present the discovery and characterization of a bacterial natural product from Bacillus methylotrophicus FZB42, a Gram-positive, rod-shaped bacterium that stimulates plant growth. A prolific producer of …
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Role of Subcellular Differentiation in Plant Disease Resistance
… of the pathway are sesquiterpenoid phytoalexins, antibiotic compounds produced by plants in response to pathogens. We are interested in the role of the defense-inducible isoforms of HMGR in phytoalexin production and disease resistance. Transgenic tobacco, constitutively expressing the …
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Discovery and characterization of ribosomally synthesized and post-translationally modified peptide natural products
… have historically been a rich source of antibiotic compounds. The genomic era has shown that bacteria harbor the potential to produce even more natural products that could be developed into new antibiotic agents to combat the alarming rise in antibiotic- resistant pathogens. Ribosomally …
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Antimicrobial resistance in soil: long-term effects on microbial communities, interactions with soil properties, and transport of antimicrobial elements
Since penicillin was discovered in 1928, antibiotic usage in human and veterinary medicine and prevalence of antibiotic resistant bacteria (ARB), has been increasing. While antibiotics and antibiotic resistance genes (ARGs) naturally occur in soils, increasing abundances of ARGs correlate with …
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Molecular Engineering Approaches against Germs, Spores and Biofilm Formation
… earth, and are highly resistant to traditional antibiotic compounds and disinfection procedures. For this reason, in the second part of this thesis, the focus was shifted from normal vegetative bacterial cells to dormant bacterial endospores: first, to unveil the mechanism behind spore extreme …