Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1614 for “"Antibiotic"”.
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Antibiotic Tolerance and Heteroresistance: Associated Fitness Costs and Potential in Evading Antibiotic Killing
… S. pneumoniae was susceptible to almost all antibiotics. Since then, this pathogen has gained resistance to a variety of antibiotic treatments, including beta-lactams, macrolides, and fluoroquinolones.</p> <p>In the first chapter, we focused on fluoroquinolone resistance in S. pneumoniae. …
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Approaches to investigating antibiotic efficacy and discovery of treatment strategies against antibiotic tolerance
While it is widely understood that antibiotic resistance is challenging the efficacy of our antibiotic therapies, there is a growing appreciation for the clinical importance of other ways that bacteria can survive antibiotic treatment. In particular, antibiotic tolerance describes a set of …
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Discovery and Optimization of a Family of Naturally Encoded Antibiotic Compounds that Evade Antibiotic
… health emergency. To combat this,novel potent antibiotics with unique modes of action are required. The classic arsenal of antibiotics used in clinical settings are largely natural products discovered by bulk fermentation of bacterial species isolates that are then extracted and purified to …
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Towards the post-antibiotic era: The role of antibiotic resistant enterococci in different sources
L esplosione del fenomeno dell antibiotico resistenza (AR) si configura come un fenomeno globale. Sebbene i batteri AR sia stati per lungo tempo esclusivamente associati ad ambienti ospedalieri e/o sanitari, nell ultimo decennio sono stati isolati sempre più frequentemente, in numerosi altri …
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Tetrin, a New Antifungal Antibiotic
Made available in DSpace on 2014-12-05T20:30:08Z (GMT). No. of bitstreams: 1 5900558.pdf: 5129560 bytes, checksum: c10299eb09840db60db3f3fbf3ff20d4 (MD5) Previous issue date: 1958
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Tracking Antibiotic Resistance throughout Agroecosystems
Widespread use of antibiotics in livestock production can result in the dissemination of bacteria carrying antibiotic resistance genes (ARGs) to the broader environment. Within agroecosystems, ARGs can pose a risk to livestock handlers, farmers, and ultimately consumers. The overall goals of this …
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Cooperative Electrostatic Polymer-Antibiotic Nanoplexes
… are difficult to treat because the recommended antibiotics do not transport into the cells efficiently. Examples include food-borne bacteria such as Salmonella and Listeria as well as more toxic bacteria such as Brucella and the Mycobacteria that lead to tuberculosis. Current treatments utilize …
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Antibiotic Drug Discovery Targeting Bacterial Metabolism
<p>Over the last century, the use of antibiotics has enabled many advances in modern medicine, making life as we know it possible. In recent years, however, emerging bacterial resistance to virtually all major antibiotic classes has resulted in a worldwide increase in morbidity, mortality, and …
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Bistability, Synthetic Biology, and Antibiotic Treatment
… with either synthetic gene circuits or antibiotics. A synthetic gene circuit is often engineered by considering the host cell as an invariable "chassis". Circuit activation, however, may modulate host physiology, which in turn can drastically impact circuit behavior. I illustrate this …
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Antibiotic resistance in the gut microbiota
Antibiotic resistance is an increasing threat to our ability to treat infectious diseases. Thus, understanding the effects of antibiotics on the gut microbiota, as well as the potential for such populations to act as a reservoir for resistance genes, is imperative. This thesis set out to …
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Mechanism of Antibiotic Activity of Filipin
Made available in DSpace on 2014-12-05T20:30:10Z (GMT). No. of bitstreams: 1 5904587.pdf: 3577092 bytes, checksum: 9e9914d9a76dca2b9762546f42f8d9f4 (MD5) Previous issue date: 1959
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Improving antibiotic therapy for Mycobacterium tuberculosis
… urgent need to understand the mechanisms behind antibiotic treatment failure and to develop new and improved therapeutic strategies. The aim of my thesis is to address these issues by exploring strategies to improve drug delivery and optimise antibiotic interactions within treatment regimens to …
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The antibiotic behavior of Canamin clay
Thesis (B.S.) Massachusetts Institute of Technology. Dept. of General Engineering, 1951.
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