Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 63 for “"Antibacterial agents"”.
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Nanostructured carriers for the delivery of antibacterial agents
Contains fulltext : 159479.pdf (Publisher’s version ) (Open Access)
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Bioactive Peptides as Antibacterial Agents and Visual Transduction
… (AMPs) are used in the development of novel antibacterial agents. The short killing time of the host pathogen with the use of BPs makes it difficult for pathogens to develop resistance in the cells. C18 is an AMP belonging to the cecropin family which I modified for evaluation as a potential …
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Synthesis and translation of novel gram-negative antibacterial agents
Pathogenic bacteria have been, and always will be, a scourge to mankind. Efforts to develop new drugs have been traditionally stymied by a lack of understanding about what properties are correlated with enhanced permeation into bacteria, with gram-negatives especially being a problem due to their …
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Synthesis of Novel Chiral Heterocyclic Compounds for Antibacterial Agents and Peptidomimetics
… as the testing of their biological activities as antibacterial. Another very interesting family of heterocycle-containing molecules are the Aeruginosins. They are a family of marine natural products isolated from a blue-green algae, which display inhibitory activity against serine proteases such …
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Expanding the versatility of aminoquinoline organometallic complexes as anticancer and antibacterial agents
… focused on the development of chemotherapeutic agents that incorporate alternative platinum-group metals (PGMs). The compelling need for novel treatment modalities has yielded the emergence of photodynamic therapy (PDT) for the treatment of various cancer types, bacterial infections as well as …
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A fragment based approach to the development of novel antibacterial agents inspired by the natural product simocyclinone D8
… and their corresponding starting reagents. Additionally, there was a need to establish a viable route towards the complex polyketide scaffold. Secondly, to generate a library of coumarins and screen for a low molecular weight fragment that could be taken forward as a lead compound. …
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The development of stapled peptides as chemical tools to investigate activin A signalling and as antibacterial agents targeting MsbA-mediated efflux
… 2. The development of stapled peptides as antibacterial agents targeting MsbA- mediated efflux Antimicrobial resistance (AMR) is a significant threat to global health and Gram-negative bacteria are a particularly challenging target. MsbA is an essential transmembrane protein in …
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SCREENING FOR POTENTIAL ANTIBACTERIAL AGENTS AND THE APPLICATION OF ISOTOPIC LABELS FOR THE CHARACTERIZATION OF THEIR EFFECTS ON THE DYNAMICS OF THE BACTERIAL 16S RIBOSOMAL RNA
… in combination with the fragments enhanced their antibacterial properties and may help combat multidrug resistance. In addition, using a chemoenzymatic isotopic labeling strategy, we observed by NMR a slight modification of the motions within the bacterial rRNA in complex with one of the …
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Application and Performance of High Entropy Metal Nanoparticles in the Field of Antibacterial
Antibacterial agents are increasingly applied and demanded in numerous industries such as the pharmaceutical industry, food industry, and medical implantation. In some industries, antibacterial agents not only need to have good antibacterial properties but also need to meet other characteristics. …
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One-Step Synthesis of Kanamycin Functionalized Gold Nanoparticles With Potent Antibacterial Activity Against Resistant Bacterial Strains
… especially gold nanoparticles (GNPs) capped with antibacterial agents are proving to be an effective and novel strategy against multi-drug resistant (MDR) bacteria. In this study, we report a one-step synthesis of kanamycin-capped GNPs (20 ± 5 nm) utilizing the combined reducing and capping …
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Antimicrobial Nanoparticles: A Green and Novel Approach for Enhancing Bactericidal Efficacy of Commercial Antibiotics
… especially gold nanoparticles (GNPs) capped with antibacterial agents, are proving to be an effective and novel strategy against multidrug resistant (MDR) bacteria. In this study, we report a one-step synthesis of antibioticcapped GNPs (25 ± 5 nm) utilizing the combined reducing and capping …
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Studies on the outer membrane of Pseudomonas aeruginosa and associated resistance properties
The aim of this thesis was to investigate antibacterial agents for use in disinfectant formulation in conjunction with benzalkonium chloride (BKC), and if possible, to synthesise novel agents based upon successful structures. Development of resistance to antibacterial agents following long-term …
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The synthesis of aminophosphonic acid derivatives & related compounds
… they have been described as: complex-forming agents with sequestrating properties, extractants, wetting agents, pharmaceutical preparations, ion exchangers, herbicides, compounds with plant growth regulatory activity; inhibitors of aminopeptidases; as structural units in peptide analogues, …
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ANTIMICROBIAL CHARACTERIZATION AND THERAPEUTIC APPLICATIONS OF NOVEL SYNTHETIC THIAZOLE COMPOUNDS AGAINST MULTIDRUG-RESISTANT STAPHYLOCOCCI AND ENTEROCOCCI
… pharmaceutical companies have left the field of antibacterial drug discovery given the high cost of innovation and low return on investment. Collectively, this highlights an urgent, unmet need to identify and develop new antibacterial agents that attack unique molecular targets in bacterial …
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Biologically Active Compounds From Caribbean Sponges
… corresponding esters were relatively inactive as antibacterial agents but because they were more stable and easier to purify, they were the compounds chosen for the structural studies. Structure elucidation of the purified esters was based on interpretation of the compounds high resolution nuclear …
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30S Ribosomal Subunit Assembly is a Target for Inhibition by Aminoglycoside Antibiotics in <em>Escherichia coli</em>.
<p>Antibacterial agents specific for the 50S ribosomal subunit not only inhibit translation but also prevent assembly of that subunit. I examined the 30S ribosomal subunit in growing <em>Escherichia coli</em> cells to see if antibiotics specific for that subunit also had a second inhibitory effect. …
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Antibacterial and Laundering Properties of Ams and Phmb as Finishing Agents for Healthcare Workers Uniforms
… purpose of this research is to examine whether antibacterial finishes can effectively reduce the presence of bacteria that have the potential for penetration and transmission on healthcare workers uniforms (HCWU). The specific objective of this research is to compare the antibacterial properties …
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Surface engineering using layer-by-layer assembly of pH-sensitive polymers and nanoparticles
… were created on magnetic microspheres to create antibacterial agents that can be manipulated using a magnetic field. In the second part, the surfaces of track-etched polycarbonate membranes were functionalized with multilayer coatings that undergo discontinuous swelling transition. Multilayers …
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