Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Antibacterial agent"”.
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Copper as an Antibacterial Agent and Disruptor of Protein Stability
… that bind Cu have also been shown to have antibacterial activity and are believed to disrupt metal homeostasis within the microbes they kill. Molecules called ionophores shuttle Cu into the cell to poison it. However, the antibacterial modes of action behind Cu and small molecule ionophores …
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Design, Synthesis, and Antibacterial Properties of Dual-Ligand Inhibitors of Acetyl-CoA Carboxylase and Mechanism of Action for the Antibacterial Agent Moiramide B
… pathogenic bacteria. A novel target for antibacterial development is acetyl-CoA carboxylase, a multifunctional enzyme that catalyzes the first committed step in fatty acid synthesis. The bacterial form of the enzyme consists of three proteins: biotin carboxylase, biotin carboxyl carrier …
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Characterization of D-boroala as a novel Broad-spectrum antibacterial agent targeting D-Ala-D-Ala ligase & designer linkers : model reactions and linear free energy relationships in the reactivity and design of solid-phase linkers
… of pathogenic bacteria to commonly used antibacterial agents is a major public health concern. During our efforts to develop transition-state analog inhibitors for bacterial cell wall–synthesizing enzymes, we observed that D-boroAlanine (D-Ala with the -COOH group replaced with a -B(OH)2 …
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Towards the total synthesis of novenamine and its analogues with modifications at C-4 and C-5
Novenamine, a known antibacterial agent, is composed of 3-0-carbamoyl noviose (novobiose) glycosidically linked to a 4-hydroxy-3-amino-coumarin unit. Its activity as a DNA-gyrase inhibitor and the absence of analogues containing 4-epi-noviose provided the rationale for developing new synthetic …
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Investigating the impact of three washing methods on antimicrobial efficacy, texture, and color of spinach and tomatoes
… accepted, it is important to re-evaluate their antibacterial effectiveness as various parameters determine the effectiveness of each method. Quality aspects should also be considered for a well-rounded analysis of the impact of current washing methods on produce after treatment and throughout …
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Thermal Analysis of Binding of Organic Pollutants to Titanium Dioxide
… classes of compounds; iodinated contrast agents (iohexol and diatrizoate), polycyclic aromatic hydrocarbons (perylene and pyrene), the antibacterial agent triclosan and the pesticide atrazine, to investigate which of the compounds are adsorbed on the surface of titanium dioxide to undergo …
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A Multifunctional Solution Composed Of TMPyP, 1,5-DHN, And Fe(III) Ions That Produces Reactive Oxygen Species (ROS) In Aerobic, Anaerobic, And H2O2 Environments
… solution has shown potential as a possible antibacterial agent and photosensitizer for PDT which possesses unique characteristics that can address many of the limitations and challenges in the field of PDT.</p>
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Antimicrobial evaluation of selected medicinal plants using molecular approach
… miss.Resistance is a major concern with any new agent, and will become even more important inthe future if new classes of drugs are established. In pharmaceutical studies, natural products,either as pure compounds or as standardised extracts, provide limitless opportunities fornovel drug leads …
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Structure-activity relationships of niclosamide to overcome colistin resistance
Antibacterial resistance poses a significant threat to global healthcare systems, particularly against Gram-negative bacteria (GNB). Addressing this challenge requires urgent development of new therapies, especially given the emergence of resistance even to last-resort antibiotics like colistin. …
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A medicinal chemistry approach to drug repositioning in the treatment of tuberculosis and malaria
… (Mtb) and P. falciparum, the causative agents of TB and malaria, respectively, has made the existing therapies less effective. Thus novel agents able to circumvent drug resistance and other challenges associated with existing TB and malaria treatments are urgently needed. The development …
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A tissue-engineered approach to hernia repair
… were individually mixed with irgasan (IRG) (an antibacterial agent) or levofloxacin (LEVO) (a broad-spectrum antibiotic). Type I collagen was later included into the polymer-drug solutions in order to increase the biocompatibility of the samples. Electrospun samples were subsequently analysed …
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Formation of Chloroform and Other Chlorinated Byproducts by the Chlorination of Antibacterial Products
Triclosan is a widely used antibacterial agent found in many personal hygiene products. While it has been established that pure triclosan and free chlorine readily react, interactions between triclosan-containing products and free chlorine have not previously been analyzed. Sixteen double-blinded …
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Tuning the Photophysical and Biological Properties of a Series of Ruthenium-Based Chromophores and Chromophore Coupled Cisplatin Analogs with Substituted Terpyridine Ligands
… supramolecules with improved DNA interaction and antibacterial properties. The impact of component modifications on photophysical and biological properties of the designed the supramolecular complexes was investigated. A series of supramolecular complexes of the type, [(TL)RuCl(dpp)](PF₆) and …
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Identification and bioactivity assessment of an antimicrobial peptide from the defensive skin secretion of the northern leopard frog, Rana pipiens
… was tested for biological activity, including antibacterial, anticancer and haemolytic.<br/><br/>As a result of the above experimental steps, the sequence of the mature peptide was identified as: FLPIIAGVAAKVFPKIFCTISKKC. The peptide sequence was identified as a known antimicrobial peptide …
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Engineered Polydopamine Nanocarriers for Biomedical Applications
… application: the design of next-generation antibacterial therapeutics, drug delivery systems, and theranostics, which combine therapeutic properties with diagnostic capabilities (Figure 1. 1). In Chapter 2, an antibacterial agent was developed by synthesising a composite of PDA and silver …
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Evaluation of Triclosan Reactivity in Monochloraminated Waters
The antibacterial agent, triclosan, is widely used in many household personal care products, and it has recently been detected in wastewater treatment plant effluents and in source waters used for drinking water supply. Accordingly, the reactivity of triclosan with the disinfectants used in …
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The discovery of the novel peptide QUB-2049 from the skin secretion of Odorrana versabilis
… QUB-2049 is a good candidate for developing an antibacterial agent against Gram negative bacteria, but optimisation would be needed to reduce its haemolytic effects.<br/><br/><p class="MsoNormal"><i>Thesis embargoed until 31 December 2026</i><i>.</i></p>
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Assessment of antimicrobial and antiproliferative activities of a bioactive peptide from the skin secretion of white-lined leaf frog
… are consistent, indicating that it can be a good antibacterial agent.
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Demonstration of novel enoyl-acyl carrier protein reductases in Vibrio cholerae
… increasing number of both synthetic and natural antibacterial compounds specifically target fatty acid biosynthesis enzymes. However, the investigations this approach has engendered have uncovered diversity in this relatively conserved pathway. The enoyl-acyl carrier protein (ACP) reductase …
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