Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Antiangiogenic therapy"”.
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Dual Targeting of Tumor Angiogenesis and Chemotherapy By Endostatin- Cytosine Deaminase-Uracil Phosphoribosyltransferase
… in many cancer types and become a first approvedantiangiogenic modalities by Food and Drug Administration (FDA) in United States.However, interruption of homeostasis in normal tissues that is likely due to theinhibition of VEGF/R signaling pathway induces unfavorable side effects. …
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Effekt einer Antagonisierung der alpha- v-Integrine auf Angiogenese, Wachstum und Metastasierung solider Tumoren in vivo
Introduction: Antiangiogenetic cancer therapy is a potential new form for treatment of solid tumors. The alpha-v-integrins ( avb3, avb5) mediate the contact of activated endothelial cells to proteins of the extracellular matrix during tumor angiogenesis as a prerequisite for survival of endothelial …
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p38 MAPK Signalling in Endothelial Apoptosis
… vasculature, emphasizes the great potency of antiangiogenic therapy in the treatment of cancer. We investigated signalling pathways in endothelial apoptosis induced by the inflammatory cytokine tumour necrosis factor alpha (TNF), the main target of which is the endothelium, and by the …
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Quantification Of Vascular Parametric Indices Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging
… kidney tumors to schedule the initiation of chemotherapy. DCE results were confirmed with the histologic studies.</p> <p>In this thesis, several new measures of vascular properties have been introduced, including: the fraction of active pixels (FAP); contrast agent uptake to the peak (AUCtp); time …
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Radiosensitization of Head & Neck Carcinoma Cells by Linifanib, A Receptor Tyrosine Kinase Inhibitor
… endothelial growth factor (VEGF). Since radiotherapy is one of the most commonly used treatments for HNSCC, it is imperative to identify the interactions between antiangiogenic therapy and radiotherapy, and to develop combination therapy to improve clinical outcome. The mechanisms between …
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An Innovative Phase I Trial Design Allowing For The Identification of Multiple Potential Maximum to lerated Doses With Combination Therapy of Targeted Agents
… metastasis. One mechanism of tumor resistance to antiangiogenic therapy is upregulation of hypoxia inducible factor 1α (HIF-1α) which mediates responses to hypoxic conditions. Temsirolimus has resulted in reduced levels of HIF-1α making this an ideal combination therapy. Dr. Donald Berry developed …
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Vasculogenic mimicry in bladder cancer and its association with cancer stem cells and human chorionic gonadotropin-beta
… some cancerous tumours acquire resistance to antiangiogenic therapy due to different angiogenic “escape “ pathways that allow tumours to restore their growth and hence can invade and metastasise. Vascular mimicry is the process of formation of tumour cell lined channels for nutrient …
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Discoveries of Targets and Novel Agents for the Treatment of Ischemic Retinopathy and Neovascular Disease
… clinical concern in patients receiving long-term therapy. Thus, targeting downstream signaling proteins linked to pathological RNV represents an alternative or adjunctive approach to approved anti-VEGF treatments, which may provide better patient outcomes through enhanced efficacy of …
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Factores pronósticos en la agudeza visual final de pacientes con oclusión venosa retiniana tratados con terapia antiangiogénica
Objetivo: determinar los diferentes factores clínicos y de imagen pronósticos para la agudeza visual final a los 3, 6 y 12 meses en los pacientes con oclusiones venosas retinianas tratados con terapia antiangiogénica. Material y métodos: estudio longitudinal de una cohorte de 60 pacientes con …