Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Antiangiogenic agents"”.
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Design and Synthesis of Pyrimidine Fused Heterocycles as Single Agents with Combination Chemotherapy Potential
… of pyrimidine fused heterocycles as single agents with combination chemotherapy potential. Major limitations of cancer chemotherapy include dose limiting toxicities of clinically used agents and the development of multidrug resistance by the tumor. Agents that interfere with microtubules are …
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Design and Synthesis of Pyrimidine Based Fused Heterocyclics in the Potential Treatment of Cancer and Opportunistic Infection
<p>Dose-limiting toxicities of clinically used agents and development of resistance are two significant limitations in cancer chemotherapy. Microtubule targeting agents (MTAs) are a structurally diverse set of compounds that disrupt microtubule dynamics and exert their anticancer effect. …
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Target Based Design and Synthesis of Fused Pyrimidines in the Potential Treatment of Cancer and Opportunistic Infection
… background and research progress in the areas of agents designed as (a) selective <em>Pneumocystis jirovecii</em> dihydrofolate reductase (pjDHFR) inhibitors for pneumocystis pneumonia (PCP) infection; (b) inhibitors of microtubule polymerization and multiple receptor tyrosine kinase (RTK) for …
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Η ΒΙΟΣΥΝΘΕΣΗ ΤΩΝ ΒΑΣΙΚΩΝ ΜΕΜΒΡΑΝΩΝ ΩΣ ΒΙΟΧΗΜΙΚΟΣ ΔΕΙΚΤΗΣ ΤΗΣ ΑΓΓΕΙΟΓΕΝΕΣΗΣ
… NEVERTHELESS IS AN EFFECTIVE TARGET FOR ANTIANGIOGENIC AGENTS. THUS, THE PROPOSED METHOD OFFERS A CONVENIENT SCREENING TEST FOR COMPOUNDS WITH ANTIANGIOGENIC PROPERTIES WITH CONSIDERABLE THERAPEUTIC USEFULNESS.
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Radiosensitization of Head & Neck Carcinoma Cells by Linifanib, A Receptor Tyrosine Kinase Inhibitor
… imperative to identify the interactions between antiangiogenic therapy and radiotherapy, and to develop combination therapy to improve clinical outcome. The mechanisms between antiangiogenic agents and ionizing radiation are complicated and involve many interactions between the vasculature, tumor …
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Design and synthesis of pyrimido[4,5-b]indoles and furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential or as inhibitors of tubulin or thymidylate synthase
… progress in the areas of multitargeted single agents and tubulin inhibitors in cancer chemotherapy and selective Toxoplasma gondii TS inhibitors for the treatment of toxoplasmosis.</p><p> Tubulin inhibitors are important antitumor agents that disrupt microtubule dynamics. Thymidylate synthase …
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Target Based Design And Synthesis of Heterocycles in the Potential Treatment of Cancer and Opportunistic Infection
… cancer chemotherapy. Microtubule targeting agents (MTAs) are a structurally diverse set of compounds that disrupt microtubule dynamics and exert their anticancer effect. Among the various classes of such agents, the colchicine site binding agents are particularly important as they circumvent …
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A mechanistic assessment of novel anticancer drugs targeting the metastatic cascade and tumour vascularisation.
… chemotherapeutics are vascular-disrupting agents (VDA) that target already established tumour blood vessels, and compounds with antiangiogenic acitivity that interfere with processes during the formation of new blood vessels. Most vascular-disrupting agents bind to tubulin and mediate blood …