Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"Antiandrogens"”.
-
Effects of the Antiandrogen Cyproterone Acetate on Maturing Male Mice.
Antiandrogens are defined as substances capable of selectively suppressing the biological activity of androgens at their target sites (Dorfman, 1970). In the last two decades, extensive use has been made of antiandrogens, both clinically and as a research tool. They have been used for hirsutism and …
-
Identification and Targeting of Downstream Ar-Camkk2-Mediated Mechanisms For The Treatment of Advanced Prostate Cancer
… of CRPC tumors resistant to second-generation antiandrogens.</p> <p>Collectively, I have leveraged orthogonal molecular, genetic and pharmacological approaches to delineate how AR-CAMKK2 signaling drives prostate cancer progression and define potential new therapeutic strategies for targeting …
-
Structural Basis for the Molecular Recognition of Androgen Receptor Ligands: Insights Guiding the Design and Synthesis of Novel Nonsteroidal Ligands
… for the androgen receptor (AR), androgens and antiandrogens alike, have therapeutic value in the treatment of various androgen-dependent conditions, from regulation of male fertility to prostate cancer. Nonsteroidal AR ligands have advantages over their steroidal counterparts with respect to …
-
Exercise as medicine : reversing treatment toxicities in prostate cancer patients
A common treatment for prostate cancer, which is the most common form of cancer after skin cancer in Australian males, is androgen deprivation therapy (ADT). However, ADT is associated with an array of adverse effects including reduced bone and lean mass, loss of muscle strength, negative change in …