Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 167 for “"Anti-viral"”.
-
The Effect Of Maternal Antibodies On Anti-Viral Immunity In Infant Mice
… vaccines for this population. While maternal antibodies can provide protection, they also inhibit the infant’s de novo antibody response. Furthermore, maternal antibodies can exacerbate disease in some contexts. Thus we need better vaccination strategies to protect infants. Here, we establish …
-
REDOX REGULATION OF B CELL ACTIVATION AND THE ANTI-VIRAL HUMORAL IMMUNE RESPONSE
… activation and proliferation. BCR ligation with anti-IgM or antigen resulted in ROI production that reaches a maximum by 15 minutes. Increased ROI coincides with elevated levels of the first oxidation product of cysteine, sulfenic acid, in the total proteome. Analysis of specific proteins …
-
Selective allodepletion to improve anti-viral and anti-leukaemic responses after haploidentical transplantation
… assays. In pentamer and IFN-γ ELISPOT assays, anti-viral responses to CMV, EBV and adenovirus were preserved after combined CD25/71 allodepletion. Finally, we showed that CD25/71 allodepleted T-cells can be redirected to recognize and secrete IFN-γ and granzyme B in response to CD19 cell lines …
-
Regulation of Anti-Viral Cd8+ T Cell Responses by the Pd-1 Pathway
… therapeutic target in cancer and chronic viral infections, where blockade of PD-1/PD-L1 reverses CD8+ T cell exhaustion and improves outcomes. However, it remains unclear how PD-1 pathway signals shape the development and maintenance of memory CD8+ T cell responses following …
-
Characterization of Host Factors and Anti-viral Compounds for Diverse Mosquito-borne Flaviviruses
… ability to convert basic knowledge into robust anti-viral therapeutics requires discovery of novel host-virus interactions as well as an informed anti-viral discovery pipeline. We used a genome-scale RNAi-based screen followed by a chemical screen of FDA-approved therapeutics to identify scores …
-
Characterization of the anti-viral effects inhibited by the vaccinia virus K1 protein
… many strategies to evade the host immune and anti-viral response. One such host anti-viral response, activation of the double-stranded RNA activated protein kinase (PKR) pathway, is important in sensing the presence of intracellular viral genomes and their products. PKR is activated by dsRNA, …
-
Sensing Foreign DNA: The Role of DNA-PKcs in Human Anti-viral Innate Immunity
… molecular patterns (PAMPs), such as viral genomic DNA, which is a major PAMP during DNA virus infection. Viral DNA sensing leads to the activation of the STING-TBK1-IRF3 signalling axis and the production of type I interferon. Previously, our work identified the non-homologous …
-
IL-1R8: A Novel Checkpoint Regulating Anti-Tumor And Anti-Viral Activity Of NK Cells
… and are able to recognize damaged, stressed, viral infected or tumor cells, which express ligands interacting with activating NK cell receptors. The expression of IL1R8 in NK cells prompted us to analyze its potential role in controlling NK cell effector functions.<br></br><br></br>Expression …
-
Impact of anti-viral immunity on neural stem/progenitor cell activity and implications for CNS development
<p>Viral infection and inflammation in the central nervous system (CNS) can cause neuropathology, particularly in the prenatal and neonatal stages. Severe damage to the CNS may result from cytopathic effects of viral infection or from the immune response that may lyse virally-infected cells or …
-
Role of Ribavirin, an Anti-Viral Agent, In Eukaryotic Initiation Factor 4e (Eif4e) Subcellular Localization and Function
Expression of eukaryotic initiation factor 4E (eIF4E) is necessary for active cellular growth and catalysis of the rate-limiting step in cap-dependent protein synthesis3-5. Studies in the past decade have shown that eIF4E contributes to malignancy by selectively facilitating the translation of a …
-
The Role of Anti-Viral Immune Response on the Therapeutic Efficacy of Oncolytic Virotherapy for High-Grade Gliomas
… replicating in cancer cells and inducing anti-tumor immunity. Among these viruses, the oncolytic adenovirus Delta-24-RGD has shown safety and efficacy in clinical trials for high-grade gliomas. Strategies to improve the efficacy of oncolytic virotherapy have aimed to heighten the …
-
The role of the DEAD box Helicase DDX3X in Anti-‐Viral Signalling Pathways Mediated by the Kinase IKKα.
The human DEAD-box RNA helicase DDX3X has previously been shown to be involved in innate immune signalling in pathways mediated by IKKε and TBK1. In this work we show that DDX3X is also involved in pathways independent of these kinases, and functions by interacting with two related kinases IKKα and …
-
Rarely Acquired Type II-A CRISPR-Cas Spacers Mediate Anti-Viral Immunity Through the Targeting of a Non-Canonical PAM Sequence
… system, the protospacer targets on the viral genome are followed by a conserved "N-G-G" DNA motif, known as the protospacer adjacent motif (PAM). The PAM identifies the phage DNA as "foreign" and triggers the Cas nuclease, Cas9, to cleave the target phage DNA. Most of the spacers present …
-
Impact of the parasitic helminth Schistosoma mansoni on host anti-viral vaccine responses: proof of concept from the anti-polio vaccine
… mice. As a proof of concept, a well-established anti-viral vaccination programme with wide global coverage, i.e., anti-polio vaccination, was evaluated for its sustainability in the face of schistosomiasis in human and mouse hosts. Our findings using the poliovirus specific enzyme-linked …
-
Utilizing Proteomic Techniques to Discover Host Protein Interactions with the E1 Glycoprotein of Venezuelan Equine Encephalitis Virus (VEEV) for Anti-Viral Discovery
… There are currently no FDA approved vaccines or antivirals to target VEEV or other closely related alphaviruses associated with clinical disease in humans. The research performed in this dissertation aimed to elucidate new antiviral targets and treatments to help bridge gaps in current …
-
The neonatal anti-viral response fails to control measles virus spread in neurons despite interferon-gamma expression and a Th1-like cytokine profile
… nervous system (CNS) and have a greater risk of viral infections and encephalopathies. Neurotropic viral infections can lead to blindness, hearing loss and neurological deficiencies such as cognitive impairment, epilepsy, and even death in the neonatal and pediatric populations. Viral infections …
-
Regulation of APOBEC3 activity and HIV-1 replication by P-body associated proteins
… play an important role in host mediated antiviral defence against retroelements, including HIV-1. Although much has been discerned regarding the anti-viral nature of these proteins, their cellular function, as well as mechanisms of functional regulation and cellular co-factors, remains …
-
Cancer Cell Antiviral Signaling Amplifies Transcription Output Through Chromatin Alterations To Drive Therapy Resistance
… We demonstrate that cancer cells co-opt anti-viral signaling to sustain genetic programs that drive resistance to multiple anti-cancer modalities. In the context of radiation resistance, upon heterotypic interaction, exosomes are transferred from stromal to breast cancer (BrCa) cells and …
Page 1 of 9