Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"Anti-tumour activity"”.
-
Arsenic trioxide in ovarian cancer
Arsenic trioxide (As2O3) has shown anti-tumour activity against a variety of solid tumours in vitro. However, the mechanisms responsible for its cytotoxicity against ovarian carcinoma remain elusive. In this thesis, the molecular determinants of its effects and factors mediating its chemoresistance …
-
Development of solid lipid nanoparticles for sustained release of anticancer agents
… mechanisms are reviewed. The potential of SLN in anti-cancer drug delivery systems is highlighted. SLN formulations of two different lipids (tristearin, stearic acid), used as carriers for the encapsulation of the anticancer drug substance curcumin (CRC), have been investigated. The …
-
Enhancing T cell immunotherapy through dosing of memory transcription factors
T cell therapies hold promise for treating solid tumours, but their efficacy is limited by poor persistence of transferred cells. Previous strategies to enhance persistence often relied on enforcing constitutively activated, and hence potentially toxic or oncogenic, T cell states. In contrast, …
-
Synthesis, characterization and applications of complexes with transition metal ions in d6, d8 and d10 configuration, with nitrogen heterocyclic ligands containing pyridinic nuclei.
… and Technologies focused on the synthesis, reactivity and applications of various nitrogen-containing heterocyclic ligands containing pyridine nuclei and their derivatives with transition metal ions, mainly in d8 configuration, including Pd(II), Pt(II) and Au(III). The ligands studied belong …
-
The Total Synthesis of Pseudonocardia sp. Quinolone Natural Products and Studies Towards the Total Synthesis of 1β-Hydroxyalantolactone
… of natural products possessing biological activity in two important areas. The first section concerns the total synthesis of six 4-quinolone natural products, four of which had never been synthesised before. These compounds were originally isolated from a soil bacterium of the genus …
-
Combination therapy studies with the vascular disruptive agent combretastatin-a4-phosphate (CA4P)
CA4P leads to rapid vascular shutdown of tumour core, with minimal effects at the well perfused periphery. CA4P showed minimal anti-tumour activity in single agent phase I studies. This thesis examined the feasibility of CA4P combination therapy, examining the hypothesis that two agents may be …
-
Investigating the genome of Anaplastic Lymphoma Kinase-positive Anaplastic Large Cell Lymphoma
… inhibitor crizotinib led to additive/synergistic anti-tumour activity suggesting this may be an appropriate combination therapy for future use in the circumvention of ALK inhibitor resistance. Indeed, crizotinib-resistant and sensitive ALCL cells were equally sensitive to GSIs. In conclusion, we …
-
Pharmacognostic study of 5 medicinal plant species from Western Cape Province (South Africa) for anti-tubercular activity
In our search for new anti-tuberculosis lead molecules, five medicinal plant species, Olea capensis (L.l, Tulbaghia alliacea (L.), Inula graveolens (L.), Leyssera gnaphaloides (L.), and Buddleja saligna (L.) were collected in Cape Town and surrounding area and investigated for antimycobacterial …
-
Role of the bone morphogenetic protein signalling in skin carcinogenesis. Effect of transgenic overexpression of BMP antognist Noggin on skin tumour development; molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin.
… in skin development and also possesses a potent anti-tumour activity in postnatal skin. To study mechanisms of the tumour-suppressive role of BMPs in the skin, a transgenic (TG) mouse model was utilized, in which a transgenic expression of the BMP antagonist Noggin was targeted to the epidermis …
-
Development and characterisation of a novel chimeric antigen receptor against LGR5
… of novel 2nd generation LGR5scFv-Chimeric Antigen Receptor (CAR) NK and CD8 T cells using flow cytometry, functional in vitro assays and in vivo tumour xenograft models. While LGR5scFv-CAR NK92 cells exhibited high specificity, they had poor efficacy in vitro and failed to survive in vivo. …
-
Role of the bone morphogenetic protein signalling in skin carcinogenesis. Effect of transgenic overexpression of BMP antognist Noggin on skin tumour development; molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin.
… in skin development and also possesses a potent anti-tumour activity in postnatal skin. To study mechanisms of the tumour-suppressive role of BMPs in the skin, a transgenic (TG) mouse model was utilized, in which a transgenic expression of the BMP antagonist Noggin was targeted to the epidermis …
-
Telomerase : a tumor marker in the peripheral blood of colorectal cancer patients
… suggests that the dissemination of circulating tumour cells (CTC) occurs early in the disease process. The first clinical results obtained suggest that CTC detection and enumeration can be used to estimate prognosis and may serve as an early marker to assess anti-tumour activity of a treatment. …
-
Pharmacological characterisation of selected pyrrolobenzodiazepines as anti-cancer agents. Pharmacokinetic and pharmacodynamic characterisation of the pyrrolobenzodiazepine dimer SJG-136 and the monomers D709119, MMY-SJG and SJG-303
… (PBD) compounds shown to have cytotoxic activity with predicted DNA sequence selectivity. Research focused upon the PBD dimer, SJG-136, selected for clinical trials, and the novel PBD monomer compounds D709119, MMY-SJG and SJG-303. SJG-136, a novel sequence-selective DNA minor groove …
-
Identification of new therapeutic targets for undifferentiated pleomorphic sarcoma
… efficacious in UPS, and (iii) explore the anti-cancer effects of lead compounds, using the models developed. The discovery of new therapeutic options for UPS has been restricted by the lack of suitable models. The first results chapter addresses this gap by characterising existing …
-
Role of cancer stem cells in breast and prostate cancer
… responsible for the initiation, propagation and tumour re-occurrence. CSC have been identified in most solid and haematological cancers and account for ~1% of the total cell population. Culturing cancer cell lines in monolayers enriches for the most dominant subpopulation which in most cases does …
-
The anticancer potential of CITme, a quinoline derivative
… quinoline derivative, synthesized as a potential antitumour agent. The aim of this study was to investigate CITme with regard to antitumour activity, toxicity and pharmacokinetics. In vitro screening for neoplastic cytotoxic effects using standard cell culture techniques revealed cytotoxic …
-
The Chemistry of Cycloaurated Complexes
… and characterised. The biological and catalytic activity (in the addition of 2-methylfuran to methyl vinyl ketone) of selected complexes was evaluated. New complexes reported in this thesis where fully characterised by NMR (¹H, ¹³C and ³¹P when appropriate) and IR spectroscopy, ESI-mass …