Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 115 for “"Anti-tumour"”.
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A novel model system for the study of anti-tumour T-cell memory
… persisting memory T-cells can be monitored. Anti-tumour immune peritoneal exudate cells (iPEC) were produced by injecting a subtumorigenic dose of the highly metastatic, ß-gal<sup>+</sup> T-Iymphoma into the ear pinna of syngeneic DBN2 mice, followed by an intraperitoneal challenge with …
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THE DESIGN OF A NOVEL ANTI-TUMOUR DRUG DELIVERY SYSTEM USING IMMUNE-DERIVED CELLS.
… of some immune-derived cells to target and kill tumour cells has been approached by use of the cells in conjunction with liposomes which have been used to carry a wide variety of therapeutic agents. The proposed delivery device combines the two approaches of targeting liposomes specifically to …
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The intersection of metabolism and oxygen in T cell function and anti-tumour immunity
… and oxygen in CD8+ T cell differentiation and anti-tumour immunity, with a particular emphasis on designing novel cancer immunotherapies. This thesis comprises four results chapters, the first three of which are centred around the metabolite glutarate, an oxygen sensitive metabolite with no …
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The dynamics of anti-tumour responses generated by chimeric antigen receptor-modified immune effector cells
… and amplified in the laboratory to target antigens expressed on tumour cells through the introduction of chimeric antigen receptor (CAR) genes. Despite considerable advances in the treatment of B cell leukaemia using chimeric antigen receptor T (CART) cells targeting the CD19 antigen, some …
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Construction and characterisation of anti-tumour antibody-based proteins for use in diagnostics and therapeutics
Considerable success in the use of monoclonal antibodies (mAbs) as a targeted approach to cancer therapy has stimulated rapid development in this field of research. Due to the complex nature of the tumour microenvironment many novel antibody formats have been designed to expand on the therapeutic …
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Synthesis of bespoke matrices to investigate a novel anti-tumour molecular target using affinity chromatography. The design, synthesis and evaluation of biotinylated biarylheterocycles used as novel affinity probes in the identification of anti-tumour molecular targets.
… (IC50 16¿640 nM) against a number of human tumour cell lines. Notably, this biological activity was independent of duplex DNA binding affinity. The compounds were tested in the NCI 60-cell line panel and COMPARE analysis suggests they have a novel mechanism of action, targeting the product …
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Autocrine prolactin signaling in breast cancer cells leads to metabolic changes and therapeutic opportunities for anti-tumour and anti-bone metastatic treatment
… slowing the progression of the hPRL-secreting tumours and increasing bone mineral density when used in a therapeutic setting in immunodeficient mice. These findings contribute to the elucidation of novel mechanisms through which autocrine hPRL signalling could stimulate breast cancer …
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Validation of shellfish isolates (glycosaminoglycans, GAGs) for development as a novel anti-tumour therapy for children : GAG action on lymphocytes/T-regulatory cells
… Ongoing research at KidsCan has identified the anti-tumour properties of novel glycosaminoglycan (GAG) compounds isolated from shellfish. However the effect of GAGs on normal lymphocyte populations is still unknown, identifying this action is essential in order to evaluate any potential use of …
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Synthesis and pharmacological evaluation of novel anti-tumour prodrugs. Synthesis and pharmacological investigations into novel MMP-activated peptide-based prodrugs of methotrexate as potential cancer therapeutics
Methotrexate (MTX) is an antimetabolite anticancer agent that is used in treatment of multiple cancers, such as acute lymphoblastic leukaemia and osteosarcoma. A lack of selective tumour toxicity is one of the major problems associated with MTX chemotherapy, especially when given at high doses, as …
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Pharmacological investigations into matrix metalloproteinase-activated anti-tumour prodrugs. In vitro metabolic and pharmacological investigations into a series of colchicine-based peptide prodrugs activated by tumour-expressed matrix metalloproteinases
… Overexpression of matrix metalloproteinases in tumour tissues relative to normal tissues has been exploited as a target for peptide-based therapeutics, to improve therapeutic index of currently used agents. The stability of MMP-activated prodrugs in normal tissue or organs is a significant …
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Role of the Innate Immune Response to DNA During Therapy with Oncolytic Viruses
… time as they replicate and spread throughout tumours. Whilst tumour lysis helps reduce tumour burden, a secondary purpose of OVs as immunotherapies is to stimulate the host's immune system culminating in a systemic anti-tumour response. To do so relies on OVs ability to trigger to two distinct …
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Effect of Systemic Versus Localized Bacillus Calmette-Guérin Immunotherapy on Bladder Cancer Progression: Novel Role for Trained Immunity
… response is critical for the induction of local anti-tumour responses. Based on this knowledge, we hypothesized that compared with the standard intravesical route, systemic intravenous administration of BCG will result in improved anti-tumour immune responses. Using a syngeneic orthotopic mouse …
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Antioxidant PRDX1 limits CD8+ T cell effector function in the tumour microenvironment
… role in detecting and orchestrating effective anti-tumour immunity. However, under this selection pressure, cancer cells progressively evolve mechanisms to undermine and subvert host immunity. Immunotherapy aimed at restoring or enhancing endogenous CD8+ T cell function has had profound …
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Fas ligand expression and tumour immune evasion; the role of prostaglandin E2 and the EP1 receptor
Background and Aim: During carcinogenesis, tumours develop multiple mechanisms to evade the immune system and suppress the anti-tumour immune response. Upregulation of Fas Ligand (FasL/CD95L) expression may represent one such mechanism. FasL is a member of the tumour necrosis factor superfamily …
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Investigating the roles of IL-25, IL-33 and ILC2s in APC-mutation-mediated colorectal cancer
… in the Adenomatous Polyposis Coli (APC) tumour suppressor gene, and are largely refractory to current cancer immunotherapies. As presented in this thesis, examination of cancer gene expression profiles from CRC patients in large, publicly available online databases indicated that …
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Interrogating the functional adaptions of Tumour-draining lymph nodes (TDLNs) and the subsequent impact of checkpoint inhibition
… (LNs) function as immunological hubs whereby antigen and naïve lymphocytes meet to facilitate an immune response. In cancers, the tumour-draining lymph node (TDLN) is where the initial anti-tumour immune response occurs. Previous studies have demonstrated that TDLNs undergo dramatic …
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The role of DNA damage associated microRNAs in enhancing the chemotherapeutic responses in triple negative breast cancer (TNBC)
… is a heterogeneous aggressive type of mammary tumour which lacks a definite tailored therapeutic approach, consequently limiting treatment options to chemotherapeutic agents. Doxorubicin has demonstrated significant efficacy in the treatment of TNBC although many patients experience recurrent …
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The role of innate immunity in pancreatic cancer progression and treatment
Immune cells are highly abundant in the tumour microenvironment of pancreatic ductal adenocarcinoma (PDAC) and they significantly influence the entire process of PDAC tumourigenesis. While the anti-tumour response is typically mediated by adaptive immunity, cells of the innate immune system can …
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The role of lymph node-derived lymphatic endothelial cells in immune modulation in the tumour microenvironment
… cancers, with lymphangiogenesis at the primary tumour and tumour-draining lymph nodes (TDLNs) associated with poor patient prognosis. As well as providing a highway for metastatic tumour cells, recent reports propose lymphatics as modulators of immunity, highlighting a need for greater …
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Pyrazole and pyrazolyl palladium(II) and platinum(II) complexes: synthesis and in vitro evaluation as anticancer agents
… metal complexes therefore offer potential as anti-tumour agents to fight cancer. This study was aimed at synthesizing and evaluating the effects of palladium(II) and platinum(II) complexes as anticancer agents.
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