Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 62 for “"Anti-tuberculosis"”.
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Genomics study of anti-tuberculosis drug-induced hypersensitivity reactions
Introduction: All first-line anti-tuberculosis drugs can be associated with all phenotypes of cutaneous adverse drug reactions (CADR). Second-line drugs are associated with much poorer outcomes. Thus, identifying the offending drug in poly-pharmacy is difficult. Re -challenge with the drug is the …
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Design and synthesis of potential chrome-based anti-tuberculosis agents
… were used for screening and MABA was used for quantitative analysis. Unfortunately, all compounds tested were inactive with an MIC value ˃62.5 μM. Ethyl 2-oxo-4-(4-oxo-6-phenyl-4H-chromen-3-yl)-6-(trifluoromethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate with reported MIC of 3.39 μM also did …
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Development of novel anti-tuberculosis drugs from African medicinal plants
Includes bibliographical references (leaves 55-63).
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Synthesis of Novel -1, 3, 5 - Triazine - Based - Anti-Tuberculosis Drugs.
… is widely visible in neglected diseases such as tuberculosis, which is an infectious disease caused by bacillus Mycobacterium tuberculosis. The urgent need in search of new biological entities to fight back TB and drug resistant TB is a drive behind this project. Several specific synthetic …
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Simultaneous quantification of first-line anti-tuberculosis drugs and metabolites in human plasma
Tuberculosis (TB) currently kills more people than any other infectious disease worldwide, the highest burden being in Africa and Asia (1). Therapy recommended for drug sensitive TB consists of a cocktail of isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA) and ethambutol (EMB), all given in a …
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Characterization and quantification of urinary metabolic biomarkers for early response to anti-tuberculosis treatment
Development of new anti-tuberculosis (TB) therapies remains a major priority to combat this infectious disease and to prevent continued transmission of the causative agent Mycobacterium tuberculosis (Mtb). However, newly developed therapies require large, lengthy clinical trials to determine the …
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Evaluation of anti-tuberculosis potentials of selected medicinal plants in Endau Rompin, Johor, Malaysia
Tuberculosis (TB) remains an escalating health crisis globally which prompts new approaches to find more effective therapeutic strategies. Medicinal plants of Malaysia have a significant role to play in being able to provide new therapeutic remedies. The local people of Kampung Peta (Jakun tribe), …
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Optimization of Lead Spectinamide Compounds as Novel Anti-tuberculosis Agents with a Pharmacometric Approach
<p>In an effort to combat the global Tuberculosis pandemic, Dr.Richard E. Lee and his group at St.Jude Children’s Research Hospital designed a novel series of anti-tuberculosis agents, spectinamides – semi-synthetic analogs of spectinomycin. Spectinamides are a potent inhibitor of mycobacterial …
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The immunopathogenic mechanism of severe cutaneous adverse reactions to first line anti-tuberculosis drugs
… endemic settings like South Africa, first line anti-tuberculosis drugs (FLTD) are the commonest cause of severe immune mediated adverse drug reactions, including Stevens Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS). …
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Outcome of Tuberculosis treatment in sputum positive patients after eight months of anti-tuberculosis therapy
… of the study was to find out the outcome of tuberculosis treatment in Sputum Positive Patients after eight months anti-tuberculosis treatment. Observation and literature review has shown that there has been an increase in the number of tuberculosis patients since 1980 .A large proportion of …
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Outcome of Tuberculosis treatment in sputum positive patients after eight months of anti-tuberculosis therapy
… of the study was to find out the outcome of tuberculosis treatment in Sputum Positive Patients after eight months anti-tuberculosis treatment. Observation and literature review has shown that there has been an increase in the number of tuberculosis patients since 1980 .A large proportion of …
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Factors associated with non-adherence to anti-tuberculosis treatment in the Vhembe District, South Africa
Background: Failure to adhere TB patients to tuberculosis therapy is a major challenge that challenges the efforts to eradicate tuberculosis. While ground-breaking approaches have been introduced to reduce the number of people who are unable to finish their prescribed TB drugs, there is still quite …
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A Pharmacokinetics and Pharmacodynamics (PK/PD) Guided Approach to Lead Optimization of Nitrofuranylamide Anti-Tuberculosis Agents
<p>Currently used treatment strategies for tuberculosis (TB) involve administration of multiple drug combinations for a minimum of 6-9 months. However, these prolonged regimens do not always achieve sterilization, as evidenced by post-therapy relapse in a subgroup of treated individuals. In an …
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A randomised controlled trial of N-acetylcysteine in the management of anti-tuberculosis drug-induced liver injury
… most common severe adverse effect of first-line anti-tuberculosis therapy (ATT). Nacetylcysteine (NAC) has efficacy in patients with paracetamol toxicity, and may be of benefit in liver injury due to other causes, such as ATT-induced liver injury (AT-DILI). Rechallenge of first line ATT after …
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Translational Pharmacokinetic-Pharmacodynamic Modeling and Simulation in the Development of Spectinamides, a Novel Class of Anti-Tuberculosis Agents
… and extensively drug-resistant (XDR) forms of tuberculosis, which still remains an important public health challenge globally. Recently, spectinamides have emerged as a novel class of anti-tuberculosis agents that overcomethe native drug efflux. Spectinamides bind to the 30S bacterial ribosomal …
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A study of pharmacokinetics of anti tuberculosis drugs in Zambian PTB patients co-infected with the Human Immuno-Deficiency Virus
… determine whether the pharmacokinetics of anti-tuberculosis drugs at steady-state are altered in HIV infected patients especially those with chronic diarrhoea.60 pulmonary tuberculosis patients, (20 HIV negative, 20 HIV positive without diarrhoea and 20 HIV positive patients with diarrhoea) …
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An examination of the implementation of the World Health Organisation's anti-tuberculosis treatment, the Directly Observed Treatment Short Course (DOTS), in poor South African communities
… dissertation examines the implementation of the anti-tuberculosis treatment, the Directly Observed Treatment Short Course, of the World Health Organisation (WHO) in poor South African communities. Research for this dissertation was carried out over a two-year period in one poor community, a …
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Characterization and Pharmacokinetics of Rifampicin Laden Carboxymethylcellulose Acetate Butyrate Particles
Tuberculosis, caused by Mycobacterium tuberculosis (MTB), is a common and potentially lethal infectious human disease. Rifampicin is a front line anti-tuberculosis drug usually prescribed in combination with isoniazid, pyrazinamide and streptomycin for a period of six to seven months. When given …
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A description of the pharmacokinetics of first line anti-tuberculosis drugs and adjunctive corticosteroid therapy in the pericardial compartment and their effect on cytokine profiles in the pericardial compartment of patients with tuberculous pericarditis
… pericarditis is caused by Mycobacterium tuberculosis infection of the pericardium, which is associated with a higher mortality, compared with pulmonary tuberculosis. Constrictive pericarditis, a significant complication of tuberculous pericarditis, contributes to this elevated mortality. …
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