Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Anti-solvent"”.
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Anti-solvent precipitation and subsequent film formation of hydrophobic drugs for drug delivery
… are soluble in various water miscible organic solvents, an effective approach is the precipitation of fine particles from solution phase while mixing with an anti-solvent. The formation, stabilization and sedimentation of these particles depend upon the discreet steps of nucleation, …
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Evaluation of the Effect of Critical Process and Formulation Parameters on the Attributes of Nanoparticles Produced by Microfluidics. Design of Experiments Approach for Optimisation of Process and Formulation Parameters Affecting the Fabrication of Nanocrystals of Poorly Water-Soluble Drug Using Anti-solvent Precipitation in Microfluidic
… microfluidic reactor with the incorporation of anti-solvent approach. The research explores the potential of this technology to enhance absorption rate and hence bioavailability of IBU via oral route, and SAL via inhalation. IBU, an anti-inflammatory drug, is classified as BCS Class II drug with …
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Characterization of crystallization processes with video imaging
… which can affect the purity, quality and quantity of the crystals produced. As a result, monitoring crystallization processes in order to better understand the underlying science is of utmost importance. To this end, various tools have been developed. They are, however, not without their …
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Antisolvent gibbsite crystallisation from synthetic Bayer liquor
… the effectiveness of using water as an antisolvent to increase the overall gibbsite yield and the associated particle behaviours under isothermal conditions. The experiments were performed in a series of batch experiments which were divided into two subsets. Firstly, the effect of …
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RECOVERY AND SEPARATION PROCESSES IN THE RECYCLING CHAIN OF POLYAMIDE PLASTIC MATERIALS TO OBTAINECO-SUSTAINABLE RAW MATERIALS
… Group), focused on developing and optimizing a solvent-based recycling process to selectively recover polyamide from post-industrial and post-consumer textile and plastic waste. The process, known as selective dissolution, involves the use of a specific solvent or solvent mixture to dissolve …
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Advanced liquid-liquid extraction : studies in a laboratory mixer-settler
… results. The temperature has proved to be a prosolvent for mass transfer in both directions but the temperature profile functioned as an anti solvent.
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Crystal engineering, Bio Pharmaceutics and Cell biology of active pharmaceutical ingredient (drug) nanoparticles. Formation and cell interaction of hydrocortisone and prednisolone nanoparticles.
… were prepared using a bottom-up approach: the anti-solvent precipitation method using microfluidic reactors. Surface modification was carried out on these nanosuspensions using cationic surfactants to obtain nanoparticles with different levels of surface positive charge as indicated by …
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Mathematical modeling, simulation, and optimal design of pharmaceutical crystallizers
… such as tablets with precisely tunable quantities of active pharmaceutical ingredients. The mathematical modeling and simulation of crystallization processes are useful in systems engineering, with the key conservation equation for the particle size distribution being a partial …
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Size reduction and polymer encapsulation of carbon black in gas-expanded solvents
… that they are easily redispersed in water or solvent to form stable nanoparticle dispersions suitable for use in ink jet inks. A prototype size reduction and encapsulation system has been constructed based on a high-pressure stirred reaction vessel designed to operate at pressures up to 200 …
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Halide Perovskites for Photovoltaics and Light-Emitting Diodes
… better photovoltaic device performance. A unique anti-solvent treatment with additive modifies both the bulk and surfaces of halide perovskites and improves the device performance significantly. Transient PL and PLQE measurements demonstrate that non-radiative recombination pathways are …
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A microfluidic platform for combinatorial synthesis and optimization of targeted polymeric nanoparticles for cancer therapy
… and drug-conjugated polymers, free drugs, and solvents are mixed at different ratios into a homogenous solution. In the assembly unit, the precursor solution is quickly mixed with an anti-solvent (i.e. water) using 3D hydrodynamic flow focusing where NPs self-assemble after complete mixing. …
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Crystallization process development and spherical agglomerates for pharmaceutical processing applications
… Aliskiren hemifumarate. The first process was an anti-solvent crystallization of an intermediate. The second process was a continuous reactive crystallization developed for the final product. The processes were able to crystallize the two compounds with both high yield (>90%) and purity (>99%). …
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Metal oxide nanostructures and hybrid perovskite semiconductor for photovoltaic application
… of phase formation. We explored the impact of antisolvent and additive on the photophysical properties and a better understanding of optical response of the perovskite materials. We hold the view that the performance improvement focused on material quality alone without complete understanding …
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Contact-free Electrical Characterisation of Novel Materials Using Terahertz Spectroscopy
… recombination. The influence of different anti-solvent treatments on the performance of triple cation mixed lead-tin perovskites to effectively remove undesired Sn<sup>4+</sup> dopants was investigated. Amongst chlorobenzene and anisole, toluene was identified to produce the champion …
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Preparation and stability of organic nanocrystals. Experimental and molecular simulation studies.
… drugs, the hypoglycaemic glibenclamide, the anti-inflammatory ibuprofen, and the anti-malarial artemisinin. The choice of crystal growth inhibitors/stabilizers was found to be critical and specific for each drug. The effect of the process variables, temperature, stirring rate, and the solute …
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Stability and precipitation of diverse nanoparticles
… aggregation behavior of the organic dispersed, antisolvent precipitated system does not follow the conventional Derjaguin---Landau---Verwey---Overbeek (D LVO) theory. But they stabilize in the long term, which is attributed to the supersaturation generated by different solubility of a solute in …
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Molecular design of nanoparticle-based delivery vehicles for pneumonic plague
… that function as both adjuvants and long-term antigen delivery vehicles in order to improve vaccination, specifically for biodefense-related applications. Chapter 1 is an introduction into the threat of bioterrorism, polymer-based controlled delivery systems and challenges associated with …
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Study of antimicrobial and antioxidant properties of new materials for development of active food packaging
… sustainable active food packaging materials with antimicrobial and antioxidant properties to ensure the safety and quality of foods and prolong their shelf-life. Firstly, a microfluidic device combining dielectrophoresis (DEP) and Raman spectroscopy was developed for a fast and dynamic …
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Fabrication of self-assembled zein nanoparticles via microfluidic chip and ultrasonic treatment
… in water or a low concentration of ethanol via anti-solvent precipitation. The traditional method to form the zein nanoparticles is dropping the zein ethanol solution into a bulk water phase with mechanical shearing, which creates the heterogeneous shear environment and uncontrolled for …