Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 116 for “"Anti-oxidant"”.
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Development of novel techniques for monitoring anti-oxidant thiols
… potential clinical merit critically appraised. Anti-oxidant sulphur compounds (cysteine, glutathione, sulphite) were selected as potential targets on the basis of their physiological role in protecting the body from damage by free radicals. The variation in their concentration within biofluids …
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Vasomotor and anti-oxidant effects of anti-ischaemic therapies.
Nitric oxide (NO) plays a fundamental role in vascular homeostasis including vasomotor tone, platelet adhesion and aggregation. The current studies examine various aspects of NO responses, including: the methodology for assessment of vascular NO responses, and identification of factors reponsible …
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Anti-oxidant Action and Anti-aging Activity of Phenylpropanoid Compounds
… we measured effects of phenylpropanoids on anti-oxidant and anti-inflammatory activity and effect of caffeic acid on wound healing in skin-incised mice. Materials & methods: The cinnamic acid derivaties, C_(6)-C₃ compounds, of Penylpropanoids are used. To investigegate the effects of …
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Potential anti-oxidant benefits of rosemary extract on fry life response of cottonseed oil
… of cottonseed oil with synthetic and natural antioxidants during frying of potato chips. Control cottonseed oil, cottonseed oil with synthetic antioxidant (TBHQ), and cottonseed oil with natural antioxidant (rosemary extract) was heated to a temperature of 370°F and 30 batches of potato chips …
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Evaluation of a novel mitochondria‐targeted anti-oxidant therapy for ischaemia-reperfusion injury in renal transplantation
… safety and efficacy of the mitochondria-targeted antioxidant MitoQ in reducing pig and human kidney IR injury using an ex vivo normothermic perfusion (EVNP) system. Over a range of 500 nM to 250 µM using a 150 pig kidneys and 80 declined deceased human kidneys, MitoQ was successfully taken up by …
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The anti-fungal and anti-oxidant properties of polyphenols extracted from the resurrection plant, Myrothamnus flabellifolia
In this study the effects of M. flabellifolia polyphenols on growth of S. cerevisiae yeast strains was investigated. This study showed that M flabellifolia polyphenols inhibited growth of both the wild type and the Δhsp 12 yeast strains largely by binding protein in the growth medium. A decreased …
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Development of novel nutrapharmaceuticals combining the anti-oxidant and anti-inflammatory properties of n-3 fatty acids with a nitric oxide donor: a potential new preventative strategy for heart disease.
… the combined beneficial cardioprotective and anti-inflammatory qualities of both groups. Synthesis of aliphatic-aminothiol conjugates has been achieved using both acid chloride (N-decanoyl cysteamine (Compound 1), N-decanoyl L-cysteine ethyl ester (compound 3)) and peptide coupling based …
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Targeted delivery of biological agents
… therapeutic effects. Selective targeting of an anti-oxidant peptide to the vasculature in the SHRSP and administration of a variety of adenovirus (Ad) 35-based vectors into transgenic mice has lead to a significant enhancement in both the effectiveness of the anti-oxidant treatment and increased …
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ADVANCED PHOSPHORUS BASED MIGRATION RESISTANT ANTI-OXIDANTS FOR CARBON-CARBON COMPOSITE AIRCRAFT BRAKES WITH INCREASED CATALYTIC OXIDATION RESISTANCE
… of oxygen they will begin to oxidize at 400°C. Anti-oxidant systems must be applied to the non-rubbing surfaces of the C/C composite stators and rotors to prevent oxidation. Currently, commercial phosphorus based coating materials are made of crystalline metal phosphates that are derived from …
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Redox mechanisms in retinal cells
… (AMD). Intracellular and extracellular anti-oxidants counteract oxidative stress to prevent tissue damage and subsequent disease. The transcription factor Nrf2 is found in mammalian cells and is a major sensor of redox changes. In response to oxidative stress, it activates numerous …
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Functionality of Azadirachta indica A. Juss (neem) in beverages
… models have shown neem to possess excellent antiinflammatory, anti-cancer and anti-diabetic properties. In the first section, we analyze commercially available neem in the United States for its bio-active potential and contrast it with traditionally consumed teas- green and black tea. We …
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Protective effect of Nicotinamide on High glucose (HG)/Palmitate (PA)-induced Glucolipotoxicity to INS-1 beta cells
… effect of NAM was due to its role as an anti-oxidant, NAD+ precursor, or inhibitor of NAD+-consuming enzyme. first, Anti-oxidant activity of NAM was investigated whether other anti-oxidant have a protective effect on HG/PA-induced INS-1 cell death. Anti-oxidant such as NAD or GSH, or …
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Human telomerase reverse transcriptase (hTERT) overexpression modulates intracellular redox balance and protects cancer cells from apoptotic cell death
… following exposure to oxidative stress. This anti-oxidant effect of hTERT is mediated via a significant increase in the ratio of reduced to oxidized glutathione (GSH:GSSG) as well as efficient recovery of the oxidized peroxiredoxin to its non-oxidized form. Our data also provide evidence for …
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The molecular mechanisms of diabetes mediated impaired wound healing and the development of therapeutic strategies.
… cell migration in vitro was studied, and an anti-oxidant (silymarin, formulated as freeze-dried wafer discs) was tested for its beneficial effect. A radial migration and a wound healing assay were developed, validated and used to assess the effect of hypoxia and/or high glucose concentration …
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Genotoxic effects of NSAIDs and hydrocortisone in bulk and nano forms in lymphocytes from patients with haematological cancers
… and prevention strategy. Studies have shown that anti-inflammatory agents have anti-tumour effects in cancers, with reduced metastases and mortality. Current use of anti-inflammatory agents in the treatment and prevention of cancer is limited by their toxicity and side effects. The emerging field …
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Early Outgrowth Cells As A Novel Therapy for Chronic Kidney Disease
… independent models of CKD, demonstrating potent anti-fibrotic renoprotective effects in the subtotally nephrectomized (SNX) rat, a well-established model of non-diabetic progressive CKD, and anti-fibrotic and anti-oxidant effects in the db/db mouse, a commonly used model of type 2 diabetic …
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Effects of fescue toxicosis and chronic heat stress on murine hepatic gene expression
… expressed due to cHS. Genes involved in the anti-oxidant pathway were up-regulated due to cHS. Genes involved in generation of reactive oxygen radicals and a number of mitochondrial expressed genes were down-regulated by cHS. However, cHS did not produce an increase in oxidative stress …
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The use of a genetic strategy to study the role of modulation of oxidative stress by uncoupling proteins 2 and 3 in the pathogenesis of Type 2 Diabetes
… oxidative stress (TAS 0.54, TOAS 0.49) suggests anti-oxidant function is a plausible mechanism to determine Type 2 Diabetes risk. The predictors of anti-oxidant stress in a family study were examined, as was the impact of UCP2-UCP3 gene cluster variation. Genetic variation in the UCP2-UCP3 was …
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A study of the metabolism and metabolomics of polyphenols using isolated rat hepatocytes and liquid chromatography-high resolution mass spectrometry
… significant benefits for health through their anti-oxidant properties. Their metabolism has been well studied; however, it would be advantageous to have knowledge of the metabolites which can be formed from these compounds in order to monitor their presence in physiological fluids such as …
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Synthesis of a Water Soluble Resveratrol Derivative as a Potential Anti-Cancer Drug.
<p>Research on development of water soluble anti-cancer drugs is one of the great challenges of modern medicinal chemistry. Resveratrol (Res) is one of the many phytoalexins producing stilbenoids present in several medicinal plants, grape skin, peanuts, and red wine. It has been found to exhibit …
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