Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Anti-neutrophil cytoplasmic antibody"”.
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The Genetics of Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis (AAV)
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a multi-systemic autoimmune disorder with evidence of circulating pathogenic ANCA. There are two main antigenic targets: proteinase 3 (PR3) and myeloperoxidase (MPO). Previous genome-wide association studies (GWAS) have …
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Global and regional central nervous system sequelae of anti-neutrophil cytoplasmic antibody-associated vasculitis
Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a devastating systemic condition affecting about 300 people per million annually. While the systemic consequences of this condition are well documented, its central nervous system sequelae are poorly understood. We performed a …
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Anti-neutrophil cytoplasmic antibody (ANCA) testing at Groote Schuur Hospital: Adherence to indications for testing
… environments. We receive the anti-neutrophil cytoplasmic antibody (ANCA) testing practices in a tertiary hospital in South Africa.
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T Helper Cell Dysfunction in ANCA Associated Vasculitis
Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is an autoimmune disease characterised by inflammation of small blood vessels that leads to organ dysfunction. Auto-reactive B cells produce pathogenic antibodies against the neutrophil enzymes, myeloperoxidase (MPO) and …
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B cell therapy in ANCA-associated vasculitis
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare autoimmune disease with a UK prevalence of 250 per million. The immunopathogenesis includes neutrophil activation by B cell-derived ANCAs, activation of the alternative complement pathway, and dysregulated T cell …
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Wegener'sche Granulomatose
… der sog. “pauci-immunen” Vaskulitiden, die mit Anti-Neutrophilen-Antikörpern (ANCA, anti neutrophil cytoplasmic antibody) assoziiert sind. Mit Hilfe der indirekten Immunfluoreszenz lassen sich ANCA im Serum der meisten WG-Patienten nachweisen. Die mit WG assoziierten sog. “klassischen” ANCA …
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Proteinase 3 and Neutrophil Apoptosis in ANCA-Associated Systemic Vasculitis
… is characterized by leukocytoclasis- dying neutrophils surrounding small blood vessels. Previous studies have shown increased plasma PR3 and increased proportion of neutrophils expressing plasma membrane-associated PR3 (mPR3+). Neutrophils were isolated by polymorphprep and membrane …
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Diagnostic and prognostic aspects of anti-neutrophil cytoplasmic antibodies in systemic vasculitis
… the diagnostic and prognostic significance of anti-neutrophil cytoplasmic antibodies (ANCA) in systemic vasculitis is investigated. The clinical significance of a capture enzyme-linked immunosorbent assay (ELISA) based on the monoclonal antibody 4A3 for detection of antibodies against …