Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"Anti-mycobacterial"”.
-
The isolation of anti-mycobacterial compounds from South African medicinal plants
Includes bibliographical references.
-
Cytotoxicity and anti-mycobacterial activities of sclerocarya birrea and Dodonae viscosa anguistifolia against MTB strain
… the world highlights the critical need for novel anti-tuberculosis compounds/drugs. Objective: The aim of this study was to determine the cytotoxicity and antimycobacterial activities of Sand Olive and Marula. Methodology: The leaves (L) and barks (B) of Dodonaea Viscosa Anguistifolia (DVA or D) …
-
Investigating permeation of anti-mycobacterial agents in Mycobacterium tuberculosis and M. tuberculosis-infected macrophages in vitro as a model for early stage tuberculosis drug discovery
… emergence of multi-drug resistance to current anti-TB drugs, exacerbated by the long treatment duration, highlights the need for new effective treatments or strategies to shorten the treatment duration, improve patient adherence and curb the alarming rates of resistance. A key challenge to …
-
Deciphering the molecular basis of the global emergence of non-tuberculous Mycobacteria as important human respiratory pathogens
… and many of them show resistance to common anti-mycobacterial drugs. It is known that the bacteria manipulate the host immune response to their advantage; however, the intracellular trafficking and survival strategies are poorly understood.<br/><br/>To address this, we have developed an …
-
A transcriptomic approach for studying the activation of dendritic cells in response to mycobacterial infections
… of a better vaccine. Dendritic cells are potent antigen presenting cells that play a key role in priming naïve T cells. Effective T cell priming is necessary for a successful protective immune response in the host against the pathogen. I have been investigating the interaction of dendritic cells …
-
Substandard antimicrobial drugs: detection methods and their contributions to antibiotic resistance
… methods to identify substandard and counterfeit antimicrobial drugs are either resource intensive or have poor specificity. This dissertation examined two issues related to poor quality antimicrobial medicines: 1) Methods to detect and prevent the consumption of substandard drugs. 2) The …
-
DE NOVO DESIGN OF ANTIMICROBIAL PEPTIDES FOR APPLICATION AS ANTI-INFECTIVE AGENTS
Antimicrobial peptides (AMPs) have gathered considerable interest as a new source of antibiotics to tackle the escalating threat of antimicrobial resistance. Adopting a de novo approach enables the rational design of short synthetic AMPs, whilst mitigating concerns of resistance development to …
-
Zebrafish Mutagenesis Study of Host Determinants of Mycobacterial Infection Outcome
… screen in zebrafish for host determinants of mycobacterial infection outcome that I participated in. Zebrafish larvae from families randomly mutagenized with N-ethyl-N-nitrosourea were infected with Mycobacterium marinum and monitored over time. Larvae with increased susceptibility to …
-
Isolation and characterisation of bioactive compounds from Vitex pinnata and associated fungal endophytes
… and several of these compounds exhibited good anticancer, antitrypanosomal and anti-mycobacterial activities. Secondary metabolites isolated from leaves of V. pinnata previously reported to exhibit good anti-inflammatory activity and interestingly the leaves were used by local Malay community …
-
Crystal Engineering of Pharmaceuticals: Modulating Physicochemical Properties of Active Ingredients by the Formation of Cocrystals
… grinding (LAG) and solution crystallisation. Antituberculosis drug, isoniazid, upon cocrystallisation with melamine, solubility has reduced as per high performance liquid chromatography assay, however, antimicrobial properties determined using REMA assay confirms that cocrystal …
-
Formulation and characterisation of an effective particulate delivery vehicle for the novel sub-unit vaccine antigen, Ag85B-ESAT-6
… of the system whilst also adding further adjuvanticity. Indeed, this formulation was effective in stimulating both a cell mediated and humoural immune response. In order to investigate an alternative to the DDA-TDB system, microspheres based on poly(DL-lactide-co-glycolide) (PLGA) incorporating …
-
Isolation, Characterization, And Application Of Novel Bacteriophages For Preventing Experimental Infection With Mycobacterium avium subspecies paratuberculosis (MAP) Of Dairy Calves
… enteritis affecting ruminants, poses a substantial economic burden of $28 million CAD annually to the Canadian dairy industry. The disease is caused by Mycobacterium avium subsp. paratuberculosis (MAP) and primarily spreads to youngstock through the ingestion of contaminated feed and water. …
-
BCG-specific T cell proliferation and cytotoxic capacity in infants as risk of tuberculosis disease, following newborn BCG vaccination
… disease. The most commonly measured outcomes of anti-mycobacterial immunity in clinical trials, specific Th1 cells, are typically thought to be protective in TB. However, to date, human mycobacteria-specific Th1 responses have not correlated with risk of TB disease. New approaches are urgently …
-
Brucella abortus RB51 vaccine: Testing its Spectrum of Protective and Curative Characteristics
… against MAP if it expresses MAP protective antigens. Therefore, MAP 85A and 35kDa proteins were expressed at low levels in RB51, and the immune responses elicited by these vaccines in BALB/c mice were evaluated. Strong anti-Brucella immunity was generated, but the anti-mycobacterial response …
-
Pharmacokinetics of Inhaled Clofazimine in Mice
… last six-month and involve multiple anti-tubercular agents. Inappropriate treatment implementation, patient non-compliance and extensive treatment regimen has led to increasing prevalence of multidrug resistant (MDR) and extremely drug resistant (XRD) Mycobacterial strains. Therefore, …
-
SYNTHESIS, CHARACTERIZATION AND EVALUATION OF BIOACTIVE MOLECULES LINKED TO PHOTOREMOVABLE PROTECTING GROUPS FOR SPATIO-TEMPORAL CONTROL OF THEIR ACTIVITY THROUGH PHOTOACTIVATION
… second project focused on the photocaging of the antitubercular drug bedaquiline, a highly potent agent against Mycobacterium tuberculosis due to its ability to deplete ATP resources by inhibiting the enzyme ATP synthase (ATPe). However, its clinical use is limited by severe cardiac and hepatic …
-
Mechanisms of Innate Immune Dysfunction During Mycobacterium tuberculosis and HIV Co-infection
… for a CLR, we also observed MGL-1-dependent anti-mycobacterial activity, evidenced by greater Mtb proliferation in BMDMs and the lung of MGL-1 deficient mice. Human CLR expression was further evaluated in a humanized mouse model of Mtb, HIV, and co-infection. Surface expression of MGL was …
-
Investigation of the potential of Spleen Tyrosine Kinase (SYK) as a target for host-directed therapy during mycobacterial infection in macrophages
… Moreover, Fostamatinib reduced the production of anti-inflammatory cytokine IL-10 and the chemokine monocyte chemotactic protein-1 (MCP-1) in macrophages infected with Mtb H37Rv. We observed that Fostamatinibrescued macrophages from cell death induced by both BCG and Mtb H37Rv. Finally, we showed …
-
Design, synthesis, and biological evaluation of Antimycobacterial agents from plant derived Betulinic acid, Oleanolic acid and their derivatives
… the isolated BA and OA with foremost first line antitubercular drug isoniazid (INH) was carried out for the first time. The co-crystal compounds were synthesized using three different conditions: I. Solvent evaporation method, II. Solvent drop method and III. Dry co-grinding method. The …
-
Design and synthesis of potential antimicrobial agents
… patients. This has prompted the search for new antimycobacterial drugs. A series of pyridine-2-, pyridine-3-, pyridine-4-, pyrazine and quinoline-2-carboxamidrazone derivatives and new classes of carboxamidrazone were prepared in an automated fashion and by traditional synthesis. Over nine …
Page 1 of 2