Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Anti-mitotic"”.
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Physical Concepts of Copolymerization of Microtubules in the Presence of Anti-mitotic Agents
… of microtubules in the presence of anti-mitotic drugs is presented in this work. A general feature of the mathematical equations is presented. The possibility of having analytical steady state solutions of dynamic equations is investigated. The structure of equations is narrowed down …
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Novel combination strategies with Aurora Kinase Inhibitors: using pre-clinical data to guide clinical trial design
Anti-mitotic drugs such as paclitaxel are successful chemotherapeutics, but their utility is limited by toxicity and resistance. My research aimed to identify novel therapeutic strategies combining current drugs with aurora kinase inhibitors (AKI) in pre-clinical models and then to design a …
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Lipoxygenase Activity in Diatoms : A New Tool to Study the Antiproliferative Effects of Diatoms on Copepod Reproduction
… past 15 years. Since the discovery of the first anti-mitotic compounds, polyunsaturated aldehydes deriving from fatty acid oxidation,our knowledge of the oxylipin metabolism in diatoms has been continuously increasing. Not only have new oxylipin compounds been identified, but it is becoming …
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Synthesis of furo[2,3-d]pyrimidines, thieno[2,3- d]pyrimidines, pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolates, receptor tyrosine kinase (RTK) inhibitors and antimitotic agents
… background and research progress in the areas of antifolates, receptor tyrosine kinase (RTK) inhbitors and anti mitotic agents has been discussed. Thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFTase) are important folate dependent …
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Mechanisms of Sensitization to Chemotherapy in Non-Small Cell Lung Cancer
… lung cancers to a variety of chemotherapies. Anti-mitotic chemotherapies have the most frequent sensitization across a large panel of non-small cell lung cancers, and the largest degree of sensitization by combination with JP1201, and this sensitization is dependent on activation of the ER …
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Development of stapled peptide targeted covalent inhibitors and synthesis of novel ADC payloads for applications in cancer therapy
… lysine residue on MDM2, an important anti-apoptotic protein overexpressed in many cancer cells. Led by computational modelling and kinetic studies on stability and reactivity of the electrophiles, an SPTCI with an apparent Kd of 7.1 nM was discovered. The stapled peptide was built …
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Discovery, characterization, and rational design of the enzymes involved in monoterpene indole alkaloid biosynthesis in Madagascar periwinkle
… are produced, including the clinically used anti-mitotic drugs, vinblastine and vincristine. The common intermediate to all monoterpene indole alkaloids is strictosidine, the product of an asymmetric Pictet- Spengler condensation of tryptamine and the iridoid monoterpene secologanin. This …
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Role Of The α1A-Adrenergic Receptor In Synaptic Plasticity, Cognition & Neurogenesis
… We used CRZ to activate α1A-ARs and the anti-mitotic agent cytosine arabinoside (Ara-C) to impair ANG in CRZ-treated and WT mice, and tested mice on novel object recognition (NOR), Morris water maze (MWM), and open field (OF). No difference was found in NOR and OF. MWM revealed that …
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Quantitative Real-Time PCR Analysis of Colchicine Pathway and Rhizome Developmental Genes
… Fever, but has shown potential as an anti-cancer drug due to its anti-mitotic properties. As demand for colchicine increases, traditional production methods lag behind as naturally-sourced colchicine is highly susceptible to environmental conditions, low yielding, and labor intensive. …
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IGF2R: A NEW PLAYER IN THE INSULIN LIKE GROWTHFACTOR 2 (IGF2) PATHWAY SUSTAINING ADRENOCORTICAL TUMOURS CELL GROWTH
… and IR, were found responsible for the IGF2 pro-mitotic signal transduction. Unfortunately, even if promising in in vitro settings, the inhibition of these receptors was not successful in prolonging the overall survival of ACC patients in clinical trial. Furthermore, in the IGF2 system is …
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PHYTOCHEMICAL AND SYNTHETIC INVESTIGATIONAL COMPOUNDS AS MODULATORS OF CYTOMETABOLIC AND CYTOSKELETAL DYNAMICS FOR PRE-CLINICAL TARGETING OF PROSTATE CANCER
… genes, (modulate epithelial cell metastatic and anti-metastatic genes) such as TGFβ, SMAD3, VIMENTIN, E-CADHERIN, SNAIL, modulating F-actin, disfavoring anoikis resistance, and disfavoring EMT through limiting cell adhesion. Furthermore, we demonstrated that lignans and other investigational …
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Development of Tools to Assess the Effects of Lunasin on Normal Development and Tumor Progression in Drosophila Melanogaster
… many bioactive molecules known to elicit anti-cancer effects. One such peptide, Lunasin, has been shown to selectively act on newly transformed cells while having no cytotoxic effect on non-tumorigenic or established cancer cell lines. In this study we attempt to understand the …