Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"Anti-inflammatory agents"”.
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Hematologic effects of cryogenine and certain selected anti-inflammatory agents
… (whether caused by micro-organisms, toxins, antigens, etc.) first leads to an increased passage of fluid through the walls of the microvasculature, followed by stasis of circulation within the affected area. This, in turn, is followed by migration of leukocytes into the area and finally …
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Discovery of Quinic Acid Derivatives as Oral Anti-inflammatory Agents
… tomentosa</em> (a.k.a. Cat’s claw) exert anti-inflammatory activity through mechanisms involving inhibition of the pro-inflammatory transcription factor nuclear factor kappa B (NF-κB). Herein, we described the synthesis and biological testing of novel QA derivatives. Inhibition of NF-κB …
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Computer aided chemical speciation in designing metal-based potential anti-inflammatory agents
… of this study was to develop copper based anti-inflammatory agents for the treatment of inflammation associated with Rheumatoid Arthritis. Four low molecular ligands, N,Nt-di(aminoethylene)-2,6-pyridine dicarbonylamine (PrDH), Bis-(N,N-dimethylethyl)-2,6-pyridinedicarboxamide (PrDM), …
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Synthesis of Novel Cannabinoid Ligands and Their Use as Anti-Glioma and Anti-Inflammatory Agents
… and intracranial models of glioblastoma. The anti-glioma efficacies of the two lead compounds were not altered by pharmacologic blockade of the CB1 and CB2 receptors which points to a non-CB1/CB2 mediated signaling pathway. This pathway was examined in the human glioma line U-87 MG and …
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Synthesis of 20S-Hydroxyvitamin D3 Analogs and Their 1α-Hydroxyl Derivatives as Potent Anti-inflammatory Agents
… is the only steroidal drug used clinically for anti-inflammatory and immune diseases. However, long-term use of 1,25(OH)2D3 (625 µg/day) in human would result in hypercalcemia (toxicity), and 1,25(OH)2D3 has substantial hypercalcemic effects (toxicity) in mice at a dose as low as only 2 µg/kg. …
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Copper chelating anti-inflammatory agents of pseudo-mimics of human serum albumin (HSA) : copper and rheumatoid arthiritis
… of the study was to develop copper based anti-inflammatory agents for alleviation of inflammation associated with RA.
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Diamino diamide copper complexes as anti-arthritic agents
… complexes with respect to their potential as anti-inflammatory agents in the treatment of rheumatoid arthritis. Several physico-chemical techniques were employed in the investigation including glass electrode potentiometry, UV/VIS spectroscopy, molecular mechanics calculations, speciation …
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Genotoxic effects of NSAIDs and hydrocortisone in bulk and nano forms in lymphocytes from patients with haematological cancers
… and prevention strategy. Studies have shown that anti-inflammatory agents have anti-tumour effects in cancers, with reduced metastases and mortality. Current use of anti-inflammatory agents in the treatment and prevention of cancer is limited by their toxicity and side effects. The emerging field …
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Role of infection and inflammation in a mouse model of preterm labour
… evidence highlights that term labour is an inflammatory event associated with increased production of pro-‐inflammatory mediators and leukocyte influx into the intrauterine tissues. Preterm labour (PTL), defined as labour before 37 weeks gestation, is a major clinical problem, and preterm …
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DEVELOPMENT OF SYNTHETIC METHODOLOGIES TOWARDS CYCLIC HYDROXAMIC ACID-BASED NATURAL PRODUCTS
… class of bioactive compounds with wide uses as anti-bacterial, or anti-inflammatory agents and a key component of many natural products, mainly siderophores (low-molecular-weight iron sequestering agents) in lower organisms. Hydroxamic acid based analogs may find potential therapeutic uses in …
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Development Of New Therapy to Combat Tuberculosis Induced Inflammation
… health problem. TB disease induces a strong pro-inflammatory response, which can lead to irreversible lung damage, even after successful antibiotic therapy. This thesis investigated the effectiveness of two anti-inflammatory agents, Tristetraprolin (TTP) and FhHDM-1, to reduce lung inflammation …
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Involvement of TGF-beta in skin photoaging
… has been demonstrated by many studies using antioxidants and anti-inflammatory agents in the mouse skin in vivo. We hypothesized that ROS produced by TGF-[beta] are key components in the tropoelastin (TE, a soluble precursor of elastin) up-regulation in dermal fibroblasts, and that TGF-[beta] …
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Synthesis and biological evaluation of functionalized benzoxaboroles as potential antimicrobial agents
… materials chemistry, and also as cross-coupling agents in synthetic chemistry. Boronic acids often function as inhibitors for various enzymes due to their unique electronic and physicochemical properties. B-hydroxy-1,2-oxaborolanes (benzoboroxoles) are a class of cyclic boronic acid derivatives …
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Anti-Inflammatory Effect of Berry Essences
… that chronic inflammation can lead to chronic inflammatory diseases including diabetes, cardiovascular diseases and cancer. This transition from acute to chronic inflammation state is usually induced by pro-inflammatory mediators and cytokines including nitric oxide (NO), prostaglandin E2 …
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The relative effectiveness of a non-steroidal anti-inflammatory medication (meloxicam) versus manipulation in the treatment of osteoarthritis of the knee
A dissertation submitted in partial compliance with the requirements for the Master's Degree in technology: Chiropractic, Technikon Natal, Durban, South Africa, 2001.
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The relative effectiveness of spinal manipulative therapy compared to Diclofenac sodium, in the management of mechanical low back pain
A dissertation presented in partial compliance with the requirements for the Master's Degree in Technology: Chiropractic, Durban, South Africa, 2001.
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The Association Between Cancer-Related-Fatigue, Response to Fatigue Treatment, and Cytokines and Their Receptors, In Patients With Advanced Cancer
… in two Randomized Controlled Trials, of anti-inflammatory agents (Thalidomide and Dexamethasone) for CRF. Responders showed improvement in FACIT-F subscale at the end of study (Day 15). Baseline patient characteristics and symptoms were assessed by FACIT-F, ESAS; serum cytokines [IL-1β …
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Characterization of Small Molecules Inhibiting the RNA Binding Protein HuR
… the protein encoded by this gene mediates the inflammatory response and its overexpression is correlated with autoimmune diseases and cancer-related inflammation. Specific drugs are already available that can inhibit TNFα protein but cause important side-effects, as insurgence of tumoral …
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