Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Anti-inflammatory agent"”.
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Thermodynamic properties of diamino-diamide ligand as potential anti-inflammatory agent
It has been found that low molecular mass copper(II) complexes are effective in the treatment of rheumatoid) arthritis (RA). Increasing the amount of copper associated with low molecular mass ligands in plasma helps to alleviate the symptoms of rheumatoid arthritis. Low molecular weight ligand, …
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Hydrogen sulfide therapy improves intestinal recovery through endothelial nitric oxide dependent mechanisms
H2S is a gaseous mediator that acts as an anti-inflammatory agent contributing to gastrointestinal mucosal defense. It promotes vascular dilation, mucosal repair, and resolution of inflammation following intestinal ischemia and may be exploited as a novel therapeutic agent. It is unclear if H2S …
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Alchemistic Polymers for the Delivery of Therapeutic Agents in Treatment of Pediatric Tracheomalacia
… such as contrast medium and therapeutic agents. The characterization of these polymers leads to the optimization of a coating platform. Using a factorial design, a library of drug delivery particles for the delivery of an anti-inflammatory agent was generated. The novel polymer containing …
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Η ΕΠΙΔΡΑΣΗ ΤΗΣ ΤΑΥΤΟΧΡΟΝΗΣ ΧΟΡΗΓΗΣΗΣ ΦΑΙΝΥΛΒΟΥΤΑΖΟΝΗΣ 'Η ΙΝΔΟΜΕΘΑΚΙΝΗΣ ΣΤΑ ΕΠΙΠΕΔΑ ΤΗΣ ΚΕΦΑΠΥΡΙΝΗΣ ΣΤΟΝ ΟΡΟ ΚΑΙ ΣΤΑ ΟΣΤΑ ΑΡΣΕΝΙΚΩΝ ΕΠΙΜΥΩΝ 2,5 ΚΑΙ 8 ΩΡΕΣ ΜΕΤΑ ΤΗΝ ΤΕΛΕΥΤΑΙΑ ΧΟΡΗΓΗΣΗ
… OR WITHOUT THE SIMULTANEOUS ADMINISTRATION OF AN ANTI-INFLAMMATORY AGENT (PHENYLBUTAZONE OR INDOMETHACIN). THE FOLLOWING HAVE BEEN CONCLUDED: THE INCREASED LEVELS OF CEPHAPIRIN IN SERUM AND IN BOTH FEMORA, AFTER SIMULTANEOUS ADMINISTRATION OF PHENYLBUTAZONE, WERE STATISTICALLY SIGNIFICANT. …
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Preparazione e caratterizzazione di due sistemi carrier: beads a base di chitosano e chitosano/alginato; nanoparticelle di N-trimetilchitosano
… to investigate their effect on the phytoterapic anti- inflammatory agent delivery. The main purpose of the present in vitro study is to have some information about their stability in the gastrointestinal tract and to formulate a drug delivery system for the oral administration of this …
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The Effect of Curcumin on Oxidative Stress and Inflammatory Markers in Recreationally Active Women and Men
… and are generated through natural processes. The antioxidant defense system typically regulates their concentrations to prevent oxidative stress-related damage. However, when ROS concentrations surpass a certain threshold and overwhelm the antioxidant defense system, it can lead to physiological …
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The Role of Inflammation in the Early Radiation Response
… radiation damage: characterize the role of the inflammatory molecules tumor necrosis factor alpha (TNF) and intracellular adhesion molecule-1 (ICAM-1) in the radiation response; evaluate the role of a novel anti-inflammatory agent as an interventional therapy to limit the radiation-induced …
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Anti-cancer effects and mechanism of actions of aspirin-like drugs in the treatment of gliomas
… only increasing from 3 to 7 months. A substantial body of clinical and preclinical evidence has suggested a role for aspirin in the treatment of cancer with multiple mechanisms of action. Aspirin is one of the most widely used drugs, successfully taken as an analgesic, antipyretic, …
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Discovery of Quinic Acid Derivatives as Oral Anti-inflammatory Agents
… tomentosa</em> (a.k.a. Cat’s claw) exert anti-inflammatory activity through mechanisms involving inhibition of the pro-inflammatory transcription factor nuclear factor kappa B (NF-κB). Herein, we described the synthesis and biological testing of novel QA derivatives. Inhibition of NF-κB …
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Bioactive surfaces for improved coronary stent performance
… in stent coatings remains to be determined. An anti-inflammatory agent, Salicylate (Sa) was incorporated into PPy coatings by electropolymerisation in the present study and four key aspects of the coatings were characterised. Firstly, the surface morphology and topography of the …
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Cannabinoid Receptor 2 (CB2) Ligands Downregulate Pro-Inflammatory Markers in Stimulated Primary Human Periodontal Ligament Fibroblasts (hPDLFs)
… of PD and exhibit increase in various inflammatory markers. Marijuana is well known for its recreational usage and is a risk factor for periodontal disease, which is seen as a concern in society for its negative health consequences. However, many medical conditions can benefit from the …
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Investigation of the mechanisms underlying the development of atherosclerosis.
… of cardiovascular disease and reduce the inflammatory burden, evident in the early stages of atherosclerosis. Thus, a potential role of testosterone as an anti-inflammatory agent has emerged. The over-recruitment and activation of leukocytes characteristic of early atherosclerosis is …
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The Regulation of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2 (SHP-2) in Brain Microglia
… Curcumin has been strongly implicated as an anti-inflammatory agent, but the precise mechanisms of its action are largely unknown. I firstly determined whether curcumin suppressed the gangliosdies-, LPS-, and IFN-γ induced microglial activation. In both rat primary microglia and murine BV2 …
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Steroid signalling in the human ovarian surface epithelium wound healing
… cancer (EOC). Progesterone is apoptotic and anti-inflammatory, whereas androgens appear cytoproliferative for hOSE. Local generation of these steroid hormones is subject to 3β-hydroxysteroid dehydrogenase (3β-HSD) activity. Moreover, action of these hormones is achieved through coupling to …
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Role of infection and inflammation in a mouse model of preterm labour
… evidence highlights that term labour is an inflammatory event associated with increased production of pro-‐inflammatory mediators and leukocyte influx into the intrauterine tissues. Preterm labour (PTL), defined as labour before 37 weeks gestation, is a major clinical problem, and preterm …
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Role of adipose tissue as an endocrineorgan in systemic inflammation
… fat tissue leading to dysregulation in the pro/anti‐inflammatory systemic balance. Adipokines and pro‐inflammatory markers are implicated in insulin insensitivity, blood glucose dysregulation, inflammation and atherosclerosis. There is a considerable amount of research into the characterization …
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The Combined Effect of In-Situ Tumor and Irradiation on Peritumoral Brain Vasculature
… on the peritumoral tissue through the angiogenic/inflammatory environment it creates rendering it susceptible to further damage by RT which may be prevented by using anti-angiogenic/anti-inflammatory agents. We have developed a rat C6 glioma brain tumor model to study the combination of tumor …
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Investigating the Anti-inflammatory Activity of Honey
… standardisation. This thesis focuses on the anti-inflammatory activity of honey. Emphasis was put on identifying the mode of action of the anti-inflammatory component, creating an in vitro assay to measure the anti-inflammatory activity of individual honeys and attempting to identify and …
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Developing a Drug Delivery System for Treatment of Vocal Fold Scarring
… many barriers. The largest being that, even if anti-scarring agents are directly injected into a vocal fold scar, these therapeutics are readily cleared or metabolized by the vocal fold tissue over a short period of time. This necessitates the need to re-inject the therapeutic multiple times in …
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The effect of synthetic cannabinoids on wound healing of chondrocytes monolayers and pseudo 3D cartilage tissue. Effect of different concentrations of synthetic cannabinoids WIN55, 212-2, URB602 and HU-308 with and without their antagonists on wound healing of chondrocyte monolayers and pseudo 3D cartilage tissue.
Studies have been conducted to highlight the anti-inflammatory and immunosuppressive properties of cannabinoids and also their potentials for cartilage repair and regeneration. Various wound healing techniques can be used to investigate the mechanisms of chondrocyte repair in monolayers or three …
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