Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Anti-infectives"”.
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Bacteriophage Endolysins: Anti-Infectives and Lysidiagnostics for the Post-Antibiotic ERA
… health and safety concern. In addition, growing antibiotic resistance poses a serious threat to our ability to prevent and treat bacterial infection and disease. Addressing these threats will require the development and application of novel therapeutics and clinical approaches. The focus of our …
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Hybrid modeling techniques to support drug-development and post-market analysis of anti-infectives
… massive use of in silico tools deals with the anticipation of plausible scenarios, which overall inform on best therapeutic options. The thesis exemplifies this model-based contribution by addressing two practical open questions within the anti-infective pipeline. The first case-study regards …
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Semisynthetic Development of Blasticidin S as an Antibiotic Lead and Development of Other Anti-Infectives
… seen a decline in discovery of new classes of antibiotics. This lack of new antibiotics is punctuated by the spread of antibiotic resistance and has placed society in a global health crisis. To mitigate the potentially devastating effects of widespread antibiotic resistance, new classes of …
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Establishment of a Long Term Cell Culture Model for Testing Anti-Infectives against Mycobacterium avium subsp. paratuberculosis
… and below the MIC in our cell culture model. The antimicrobials were found to be effective at different stages of cell culture infection and in different strains of MAP. Some drugs were more effective at early stages of MAP infection, whereas others were more effective in chronic or latent stages …
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Synthesis and structure-activity relationship studies of novel anti-infectives for cross screening in tuberculosis and malaria disease models
… (phthalimides) with the potential of having antituberculosis activity, presumably targeting acetolactate synthase, were synthesized. Studying the general approaches to the synthesis of sulfonyl ureas, the general procedure is to either react a sulfonamide with an isocyanate in the presence of …
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Utilisation of efficient reactions to combine moeities exhibiting biological activity to produce novel anti-infectives against HIV and malaria
… (CQ) was previously identified as a potential anti-HIV agent and reported to inhibit the production of infectious viral particles at concentrations which are non toxic to human cultured cells. It is speculated that this activity is associated with the decreased production of the heavily …
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New Strategies for the Qualitative and Quantitative Analysis of Nitrofural and Its New Derivatives // Нови стратегии за качествения и количествен анализ на Nitrofural и неговите нови производни
… drugs. The necessity for synthesising new anti-infectives is closely related to the ongoing manifestation of bacterial resistance. In this regard, the influence of Nitrofural polymorphism on the specific spectral (Infrared) behaviour of the semicarbazone C=O functional group was …
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Clarithromycin nanocrystals for high-dose inhalation
… access to care is limited. Standard oral / i.v. antibiotics often require high systemic doses to reach effective lung levels, increasing adverse effects, lowering adherence and fostering resistance. This work developed a high-dose inhalable dry-powder approach to deliver clarithromycin locally. …
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Dna Aptamers Selected Against Wild-Type Helix 69 Ribosomal Rna And Their Implications In Combating Antibiotic Resistance
<p>Outbreaks of advanced antibiotic-resistant strains of microbes have hastened the need to identify new viable molecular targets for the development of novel anti-infectives. For this purpose, helix 69 (H69, or m3a 19-nucleotide (nt) hairpin motif that is highly conserved throughout …
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Does the human skin microbiome adapt to antibiotic exposure?
Staphylococcus epidermidis is a substantial element of the healthy human skin microflora and can become pathogenic to cause infections, for example, septicaemia and endocarditis. The effects of long-term sub-lethal exposure to antibiotics on the skin microbiota are unknown. How does antibiotic …
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Renal Toxicity Warnings and Precautions of Drugs Marketed in the US
… classes with renal toxicity boxed warnings were anti-infectives for systemic use, antineoplastic and immunomodulating agents, and alimentary tract and metabolism. The most common boxed warnings were renal impairment, nephrotoxicity, and nephrogenic systemic fibrosis, with some warnings referring …
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In vivo display: a selection and its derivatives for antimicrobial peptide lead identification
<p>The rise of antibiotic resistance necessitates new approaches for the isolation of new antimicrobials with novel inhibitory mechanisms, bypassing the development of rapid resistance by modification of pre-existing resistance mechanisms. In response, we have developed a series of systems for the …
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Cystic Fibrosis Transmembrane Conductance Regulator Modulator Therapies in Cystic Fibrosis: A Retrospective Evaluation of a Nationwide Specialty Pharmacy Database
… classes for other medications included anti-infectives (n=2472, 22.81%), respiratory (n=2192, 20.23%), and electrolytes and dietary supplements (n=1701, 15.69%). The costs ranged from $0.2-$98,175 for all the other medications reported by the patients.</p> <p>Conclusion: Patients with CF …
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Optimization of Lead Spectinamide Compounds as Novel Anti-tuberculosis Agents with a Pharmacometric Approach
… Research Hospital designed a novel series of anti-tuberculosis agents, spectinamides – semi-synthetic analogs of spectinomycin. Spectinamides are a potent inhibitor of mycobacterial ribosomes and overcome efflux mediated drug resistance in M. tb. Spectinamides have shown an excellent in vitro …