Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Anti-estrogenic"”.
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The anti-estrogenic and liver metabolic effects of DHAA in rainbow trout (oncorhynchus mykiss)
… acid present in pulp and paper mills, may have anti-estrogenic effects in fish. A chronic-exposure toxicity experiment using immature rainbow trout (Oncorhynchus mykiss) was conducted in order to assess the endocrine disrupting and liver metabolic effects of the wood extractives DHAA and β- …
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Biochemical and Biophysical Studies on the Human Estrogen Receptor and Receptor Co -Regulator Interactions
… of the tissue selective pharmacology seen with estrogenic and anti-estrogenic compounds.
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Zebrafish as a Model for Studying Estrogen Signaling and Estrogenic Endocrine Disruption
… range of chemicals, which are classified as estrogenic endocrine disruptors (EEDs), can bind to ERs or GPERs, thereby interfering with estrogen signaling and causing adverse effects. Zebrafish embryos/larvae are an emerging model used in xenoestrogen studies. However, endogenous estrogen …
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The Development of Novel Non -Steroidal Subtype Selective Ligands for the Estrogen Receptor
… bearing basic side-chains in the hope to impart anti-estrogenic activity to this class of ligands. The basic side-chain furan analogs were also ER-alpha binding selective ligands (2--47 fold selectivity) and transcriptional assays have shown one particular member of this series (Chapter 5, 17b) …
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Lifetime Occupational Exposure to Endocrine-disrupting Chemicals and Postmenopausal Breast Cancer Risk: A Montreal-based Case-control Study (2008-2011)
… by their biological mode of action as, estrogenic, anti-estrogenic, or anti-androgenic. Exposure metrics derived included, ever/never exposed, duration of exposure (per 5-year increase), cumulative exposure (per interquartile range) and average concentration of exposure (per 1-unit …
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ROLES OF HAND2 TRANSCRIPTION FACTOR IN UTERINE RECEPTIVITY AND DECIDUALIZATION
… HAND2 was an important factor that mediates the anti-estrogenic effect of progesterone on luminal epithelial proliferation. The abnormal in expression of Mucin 1, Calcitonin and E-Cadherin in Hand KO uterus may be responsible for defects in the uterine receptivity. The expression of HAND2 was …
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Hormonal regulation of bone health: novel understandings of xenoestrogens and estrogen receptor-[alpha]
… or environmental compounds that have anti-estrogenic qualities, is increasing in industrial countries, but the impact of these compounds on skeletal health in males and females remains unknown. In this dissertation, we used animal models to explore a, the importance of estrogen …
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The effects of artificial and natural sweeteners on various physiological systems
… by molasses may be associated with increased antibody production that acts in defense against extracellular pathogens. Conversely, high IL-6 levels may be associated with the development of hypersensitivity reactions. Based on this outcome, we aimed to further investigate the comparative …
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Elucidation of the Molecular Mechanisms Underlying Estrogen-Mediated Estrogen Receptor Activation
… algebraic relationships. These findings quantitatively define how steroid nuclear receptors select the ‘appropriate’ regulatory targets out of a very large number of highly similar sequences in the genome, thus eliciting a specific cellular response (Chapter 3).</p><p>Estradiol is a potent …