Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Anti-cancer immunity"”.
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Engineering protein-based modulators of allergic, temporal, and checkpoint blockade anti-cancer immunity
Effective cancer treatment of the future requires incorporating diverse and innovative aspects of immunity to fight against cancer, accounting for pharmacokinetic and temporal barriers of therapeutics, and engineering approaches to understand and improve upon current immunotherapies. This thesis …
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The role of tissue-resident immune cells in PanIN to PDAC progression
… (PDAC) is one of the leading causes of cancer deaths worldwide. PDAC is recalcitrant to current immunotherapies, largely due to local suppression of anti-tumour immunity. Tissue-resident group 2 innate lymphoid cells (ILC2) are emerging as important immune modulators of the cancer …
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Immune Checkpoint Blockade Induces Gut Microbiota Translocation That Augments Extraintestinal Anti-Tumor Immunity
… immune checkpoint blockade therapy (ICT) for cancer. The mechanisms by which gut microbiota augment extraintestinal anti-cancer immune responses, however, are largely unknown. Here, we find that ICT induces the translocation of specific endogenous gut microbiota into secondary lymphoid organs …
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Enhancing Anti-Cancer Immunotherapy by Disruption of the non-Receptor Tyrosine Kinase Fes
Cancer immunotherapies are based on the principle that a patient’s own immune system can be engaged to fight their disease. While effective activation of the immune system is crucial for the success of cancer immunotherapies, native checkpoint mechanisms exist to limit immune activation and …
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A materials-based approach for localized delivery of cancer immunotherapy
Cancer immunotherapy provides a promising new alternative to traditional cancer treatment modalities such as chemotherapy and radiation. However, even the most effective therapies only show benefit in a subset of patients when used alone and so, combination therapy may be critical to maximizing …
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Mechanisms of microenvironmental paracrine signaling in cancer chemoresistance
… a major barrier to the effective treatment of cancer. Cancer therapy occurs in the context of a tissue environment, with cancer cells surrounded by many non-malignant cells that contribute to tumor growth and resistance to therapy. Yet much remains unknown about the tumor microenvironment and …
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Re-Designing Cancer Immunotherapy to Enhance Anti-Tumor Immunity
… Using MSC, we delivered various forms of anti-CD3 and/or co-signals to explore their contribution to re-activate T cells inside the TME. Combined α-CD3 and CD40L rather than CD80 leads to superior anti-tumor efficacy compared to either alone. Mechanistically, TCR activation of pre-existing …
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Quantitative cellular and molecular imaging of the intact tumor microenvironment.
… of tumor-associated immune responses in cancer are not well defined and are likely multifactorial including cancer cell heterogeneity, host genotype, and the immune status of individual patients. Tumors are complex and organized tissues that include multiple cell types, which together …
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The roles of the chemokines CXCL12 and CXCL16 in breast cancer.
… receptors in the progression of various types of cancer, including breast cancer. However, as potent chemotactic factors for leukocytes, chemokines also have the potential to enhance anti-cancer immunity. Evidence suggests that the chemokine CXCL12 and its receptors may be important in a number of …
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Autogramin-2, a synthetic sterol, inhibits T cell adhesion and effector function
… cholesterol is a key regulator of T cell immunity as it stabilises immune synapses, thus supporting effector T cell function. Recent publications suggest that increasing plasma membrane cholesterol content boosts anti-viral and anti-cancer immunity in T cells. Inhibition of cholesterol …
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Utilizing the Immunomodulatory Effects of Electroporation for Treating Brain Tumors
… many other solid tumors, recent advances in cancer immunotherapies have also shown disappointing outcomes in GBMs. The heterogenous nature of GBMs, the immunosuppressive tumor microenvironment and the restrictive role of blood brain barrier (BBB) are some of the main challenges faced for …