Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 85 for “"Anti-cancer drugs"”.
-
Quantitative pharmacoproteomics investigation of anti-cancer drugs in mouse. Development and optimisation of proteomics workflows for evaluating the effect of anti-cancer drugs on mouse liver
Minimizing anti-cancer drug toxicity is a major challenge for the pharmaceutical industry. Toxicity is most frequently due to either the direct interaction of the drug on previously unidentified targets or its conversion to metabolites by drug metabolizing enzymes (e.g. CYP450 enzymes) that cause …
-
Synthesis of Marine Chemicals and Derivatives as Potential Anti-Cancer Drugs.
… activity towards the inhibition of prostate cancer cell growth using staurosporine a a positive control. All three compounds have shown significant inhibition of prostate cancer cell growth. Compound <b>9</b> is yet to be evaluated.</p>
-
Synthesis of Ester Derivatives of Resveratrol as Potential Anti-Cancer Drugs
… red wine. Resveratrol has been found to exhibit anti-cancer, anti-inflammatory, anti-aging, and anti-oxidant properties. Research indicates that diets enriched with resveratrol containing substances result in less incidence of cancer. Unfortunately, the low bioavailability and solubility has been …
-
An Investigation of the Coordination Chemistry of Certain Anti-Cancer Drugs
Made available in DSpace on 2014-12-05T19:38:00Z (GMT). No. of bitstreams: 1 6206127.pdf: 3382935 bytes, checksum: 7f10ef0b0b50988c1ea77a2044728f9c (MD5) Previous issue date: 1962
-
Computer-aided drug design and the biological evaluation of anti-cancer drugs
… transcription factor that has a pivotal role in cancer survival and Pentamidine, an anti-parasitic drug that has recently been demonstrated to possess tumour-killing activity. A hierarchical methodology consisting of a similarity search followed by structure-based virtual screening of the ZINC …
-
Identification of determinants of sensitivity to duocarmycin analogues: A class of potent anti-cancer drugs
… pre-clinical development as hypoxia-activated prodrugs and as so-called payloads for antibody-drug conjugates for the treatment of cancer. Although the mechanism of action (MOA) of duocarmycins has been elucidated as DNA minor groove alkylation, not much is known about the factors involved in the …
-
The relationship between p53 mutations and differential sensitivity to anti-cancer drugs in oesophageal cancer cell lines
In South Africa, cancer of the oesophagus is the leading cause of death in black males and overall the fourth most common cancer. Development of resistance to chemotherapeutic agents hinders the successful treatment of several cancers. In order to characterise drug resistance in several South …
-
Decoupling market incumbency from organizational experience : a study of biotechnology's impact on the market for anti-cancer drugs
In studies of creative destruction, scholars agree that, within research-intensive industries, the demise of incumbents is significantly determined by their lower productivity in researching the radically new technology (Henderson, 1993). Such differences in the research competence of incumbent vs. …
-
Applying System-Theoretic Accident Model Process view to patient safety for treatment with oral chemotherapy and anti-cancer drugs
Although the use of anti-neoplastic chemotherapy provides benefit to patients with both malignant and non-malignant diseases, the use of these agents can be at times associated with safety concerns for both patients and the healthcare workers that administer the medication. In order to mitigate the …
-
Study Of The Photodegradation And Photostability Of Anti-Cancer Drugs In Different Media Towards The Development Of Both New Actinometers And Liquid Formulations
… and liquid formulation development. Three anti-cancer drugs will be employed as models; Dacarbazine (DBZ) has well established photostability issues, Axitinib (AXI) and Sunitinib (SUT) are two new drugs only commercially available in solid dosage forms. In ethanol, the photokinetics of …
-
Nuclear Factor Kappa B Pathway and human cancer therapeutics
Cancer is one of the major causes of morbidity in the world. Although the overall survival of cancer has been significantly improved by chemotherapy in the last three decades, the success of cancer chemotherapy is still severely limited by the lack of selectivity of anti-cancer drugs to malignant …
-
Preclinical evaluation of pharmacological strategies designed to enhance the activity of established and novel anti-cancer drugs. Synopsis: Evaluation of pharmacological strategies designed to modulate the Warburg effect, enhance the activity of tyrosine kinase inhibitors and novel analogues of Temozolomide.
… has been made in reducing mortality in some cancers, mortality rates remain high in many cancers and there is a need to develop novel therapeutic strategies. In this thesis, various pharmacological strategies designed to enhance the activity of existing therapeutic drugs were evaluated. …
-
Preclinical evaluation of pharmacological strategies designed to enhance the activity of established and novel anti-cancer drugs. Synopsis: Evaluation of pharmacological strategies designed to modulate the Warburg effect, enhance the activity of tyrosine kinase inhibitors and novel analogues of Temozolomide.
… has been made in reducing mortality in some cancers, mortality rates remain high in many cancers and there is a need to develop novel therapeutic strategies. In this thesis, various pharmacological strategies designed to enhance the activity of existing therapeutic drugs were evaluated. …
-
Lithium-Carbonate as a Protectant Against Chemotherapy-Induced Myelosuppression
Lithium carbonate has been used as an adjunct to cancer chemotherapy to lessen the dose-limiting myelosuppressive effects of several anti-cancer drugs. Its mechanism is unknown, but several possible sites of action have been considered. Lithium causes a neutrophilia and may protect the bone marrow …
-
Synthesis of Paclitaxel Analogs
Paclitaxel is one of the most successful anti-cancer drugs, particularly in the treatment of breast cancer and ovarian cancer. For the investigation of the interaction between paclitaxel and MD-2 protein, and development of new antagonists for lipopolysaccharide, several C10 A-nor-paclitaxel …
-
Synthesis of a Water Soluble Resveratrol Derivative as a Potential Anti-Cancer Drug.
<p>Research on development of water soluble anti-cancer drugs is one of the great challenges of modern medicinal chemistry. Resveratrol (Res) is one of the many phytoalexins producing stilbenoids present in several medicinal plants, grape skin, peanuts, and red wine. It has been found to exhibit …
-
Effectiveness of a closed system device in reducing occupational exposure and environmental concentrations of anticancer drugs
Owing to their non-selective nature, anti-cancer drugs affect both cancerous and non-cancerous cells and present a major health risk to healthcare staff working with them. This project was conducted at Derriford Hospital, Plymouth, to investigate the extent of contamination with anti-cancer drugs …
-
Development and application of novel analytical methods for molecularly targeted cancer therapeutics
… clinical development and routine use of anti-cancer drugs. In furtherance of this important aim, the research in this thesis sought to develop and apply novel, highly sensitive, analytical methods to examine and understand correlations of drug levels with drug resistance mechanisms, …
-
THE ROLE OF FAM3C IN LUNG CANCER METASTASIS
Lung cancer is the leading cause of cancer related deaths worldwide. The mechanisms of lung cancer metastasis are not completely understood. This field of research has garnered renewed interest ever since the discovery of vesicle-based cell-cell communication mediated by exosomes. In this study, …
-
Multiscale Monte Carlo study of epidermal growth factor receptor diffusion and dimerization
… of receptors is dysregulated in a number of cancers, and the signaling pathway of this receptor family is a critical target for several anti-cancer drugs. Therefore, a detailed understanding of the mechanisms of receptors activation is critical. However, despite a plethora of biochemical …
Page 1 of 5