Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 74 for “"Anti-cancer agents"”.
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Synthesis and biological evaluation of potential anti-cancer agents
… used to prepare a large number of compounds of anti-cancer screening. A library of caffeic acid derivatives has been prepared by the Knoevenagel condensation of aldehyde and active methylene reagents. These products have been screened against two murine adenocarcinoma cell lines (MAC) which are …
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Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents
… signalling pathways is often associated with cancer. TheRhoA/ROCK kinase pathway has been shown to be constitutively expressed in many cancersand has also been shown to be involved in metastasis and apoptosis. ROCK is inhibited bythe ATP mimic Y27632, which competitively binds the ATP binding …
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Synthesis and evaluation of novel ellipticines as potential anti-cancer agents
… is a natural product which possesses multimodal anti-cancer activity. This thesis encompasses the synthesis and biological evaluation of novel ellipticine and isoellipticine derivatives as anti-cancer agents. Expanding on previous work within the group utilising vinylmagnesium bromide, …
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A Structure-Activity Relationship Study of Dihydroajoenes as Anti-Cancer Agents
… garlic is known to possess in vitro and in vivo anticancer activity based on the presence of a vinyl disulfide as its pharmacophore. This thesis reports on the synthesis of dihydroajoenes, a novel set of ajoene analogues, containing a saturated double bond, in which the intention was to study the …
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Synthesis and evaluation of benzoyl containing compounds as potential anti-cancer agents
… as one of the major causes of death worldwide, Cancer requires the development of effective treatments in order to combat the disease. However, pharmaceutical companies are faced by the challenge of finding and developing a suitable compound that can override the barriers of the human body and …
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Synthesis and Evaluation of Benzoyl containing compounds as potential anti-cancer agents
… as one of the major causes of death worldwide, Cancer requires the development of effective treatments to combat the disease. However, pharmaceutical companies are faced by the challenge of finding and developing a suitable compound that can override the barriers of the human body and operate …
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Design, synthesis and development of novel indolocarbazole derivatives as potential anti-cancer agents
… investigation of their potential as successful anti-cancer agents. Following initial investigation of classical routes to indolo[2,3-a]pyrrolo[3,4-c]carbazole aglycons, a new strategy employing base-mediated condensation of thiourea and guanidine with a bisindolyl β-ketoester intermediate …
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Novel ferrocenyl benzoyl peptide esters as anti-cancer agents and ferrocenoyl self assembled monolayers as anion sensors
… in vitro against the non-small cell lung cancer cell line, H1299 (cisplatin and carboplatin resistant variant). The potential production of hydroxyl radicals would be enhanced by the benzoyl spacer as this lowers the redox potential of the ferrocene moiety thus making the iron atom easier …
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The synthesis and characterization of new sulfoxide complexes of ruthenium and their potential as anti-cancer agents
Areas of hypoxia (low O₂ content) within malignant tumours are often resistant to radiotherapy and chemotherapy. Compounds that work in conjunction with radiation or alone are required to remove or define hypoxic areas. The complexes cis-RuCl₂(DMS̲O)₃(DMSO̲) (1) and cis-RuCl₂(TMS̲O)₄ (3) (the …
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Antioxidants and natural anti-cancer agents in the large bowel and the influence of intestinal microbial fermentation.
Epidemiological studies of colorectal cancer, in particular time trends in migrant and religious groups, indicate that environmental factors might be of importance in determining the incidence of disease in a given population. Of the possible environmental factors implicated in cancer of the large …
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Studies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agents
The first part of the thesis describes synthesis of 10-( 4-methoxyphenyl)-4,5,9-trithia-deca- 1 ,6-diene (25) as an ajoene mimic and as a mixture of EIZ-geometrical isomers using new synthetic methodology. 4,5,9-trithia-dodeca-1,6-diene 9-oxide (43), 4,5,9-trithia-dodeca-,6- ene 9-oxide (44) and …
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Synthesis and Characterization of Carbon Monoxide Producers Bipyridine Flavonolate Palladium(II) and Platinum(II) Complexes: Potential Anti-Cancer Agents
… the effort to find more effective and selective anti-cancer<strong> </strong>treatments. Carbon monoxide, CO, is known to induce mitochondrial collapse in cancer cells. Herein is described the synthesis of seven novel bipyridine flavonolate palladium(II) and platinum(II) complexes with the …
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Design and Synthesis of Pyrimidine Based Heterocycles as Potential Anti-cancer Agents with Combination Chemotherapeutic Potential or Targeted One Carbon Metabolism Inhibition and Anti-opportunistic Agents
… pyrimidine-based heterocycles as a) single agents with combination chemotherapy potential having dual antiangiogenic effects and cytotoxic effects or b) one-carbon metabolism inhibitors for targeted tumor therapy; or c) selective <em>Pneumocystis jirovecii </em>(pj)<em> </em>dihydrofolate …
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Pharmacological characterisation of selected pyrrolobenzodiazepines as anti-cancer agents. Pharmacokinetic and pharmacodynamic characterisation of the pyrrolobenzodiazepine dimer SJG-136 and the monomers D709119, MMY-SJG and SJG-303
… profiles in mice, and warrant further study for anti-tumour activity in vivo and progression to use in patients.
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Design and synthesis of new metallo-organic complexes and their evaluation as anti-cancer agents. Synthesis, characterisation and biological evaluation of novel, late first row transition metal schiff base complexes, as anti-cancer metallopharmaceuticals
… and will be used to direct the design of new anti-cancer metallopharmaceuticals going forward. This thesis details the synthesis of a library of Schiff base macroacyclic ligands and their novel late first row transition metal complexes with varying anionic counterparts. The creation of a …
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Functional genetics reveals surprises about the mechanisms of action of chemotherapeutics
Chemotherapy for the treatment of systemic cancer originated over half a century ago. Thus, many of our most successful therapies were implemented clinically without the wealth of molecular and genetic knowledge we have today. Other than empirically determined survival benefit, another primary …
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Isoprenoid Biosynthesis Pathway as a Drug Target for Bisphosphonates: Transcriptional Profile Investigation
… related disorders such as osteoporosis and bone cancer. Here we describe the development, testing and study of the mechanism of action of novel bisphosphonates as anti-bacterial and anti-cancer agents. We identified a FPPS bisphosphonate inhibitor which in combination with the phosphonate drug …
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Investigating the Receptor Interactions and Mechanisms of a Folic Acid-Conjugated Nanoparticle in the Treatment of Breast Cancer
… a highly specific drug delivery system (DDS) for anti-cancer agents. Chemical engineering of a “smart” DDS to specifically target tumor cells has gained interest in cancer research, designed for safer, more efficient, and effective use of chemotherapeutics for the treatment of cancer. However, the …
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