Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 67 for “"Anti-cancer activity"”.
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The anti-cancer activity of extracts derived from millets and Kraalbos
Breast cancer is the second most commonly diagnosed cancer and the leading cause of cancer deaths in women. Several factors, such as the costs of anti-cancer drugs, drug resistance and relapse, make it difficult to treat this disease effectively. In the South African context this is exacerbated by …
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A novel mechanism for the anti-cancer activity of aspirin and its analogues
Abstract Colorectal cancer (CRC), which includes cancer of the large bowel and rectum is the third most common cancer in men and the second in women and there is a poorer survival rate in less developed regions of the world such as West Africa mainly due to the ‘out of reach’ costs of chemotherapy. …
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Correlation of Aqueous Solubility and Anti-Cancer Activity of Novel Triazolium and Imidazolium Salts
… and benzimidazolium salts are known to possess anti-cancer properties and have potential as cancer therapeutics. This thesis describes the aqueous solubility and the differential activity of N,AT-bis-substituted-l,2,4-triazolium bromide salts and N/N'-bis(naphthylmethyl)imidazolium bromide salts …
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The role of TBX2 and the anti-cancer activity of chromomycin A5 in pancreatic ductal adenocarcinoma
… as a TBX2-specific inhibitor with demonstrated anticancer effects in several cancer types. However, its efficacy in PDAC and the specific molecular mechanisms remains unexplored. This study aimed to: (1) elucidate the role of TBX2 in PDAC progression and its potential as a therapeutic target, …
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Developing Zebrafish as an In Vivo Model to Screen Compounds for Anti-Cancer Activity in Human Breast Cancer
Breast Cancer (BC) is the most frequently diagnosed cancer; 1:8 women are at risk of developing BC in her lifetime. Cancer metastasis causes the majority of deaths in BC patients. Moreover, side effects of traditional chemotherapeutic drugs (TCD) impair the quality of life of these patients. …
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The anti-cancer activity of a novel palladacycle, BTC2, in oestrogen receptor positive and triple negative breast cancers
Breast cancer remains the leading cause of cancer death among women worldwide. This is in part due to late diagnosis, high recurrence rate and the development of drug resistance. Indeed, even though oestrogen receptor-positive breast cancers are known to respond to hormonal therapy, drug resistance …
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DESIGN, SYNTHESIS OF SUBSTITUTED PURINES, PHENYLPYRROLIDINE DERIVATIVES, CYCLIC AND ACYCLIC BIS(p-NITROBENZENESULFONAMIDES), AND IN VITRO ANTI-CANCER ACTIVITY AGAINST LUNG, BREAST AND PROSTATE CELL LINES
… l organismo. Lo sviluppo di nuovi farmaci antitumorali è una delle attività prioritarie nell'ambito della ricerca chimico-farmaceutica, non solo per l alta incidenza ma anche per i numerosi inconvenienti legati ai farmaci in uso. Il progetto di ricerca è stato indirizzato al disegno, …
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The glucosinolate/myrosinase system: variation in glucosinolates, hydrolysis products, transcript abundance, and quinone reductase bioactivity in Brassica sp. crops
… these compounds have long been associated with anti-cancer activity in mammals through the induction of phase II detoxification enzymes, among other mechanisms. For this reason, the improvement of anti-cancer activity through selective breeding of edible plants that produce glucosinolates, such …
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Determining the in vitro anti-cancer effects of various novel indoles and an anti-microbial peptide towards a potential treatment of glioma.
… related structures are known to exhibit potent anti-cancer activity against human breast cancer cell lines, and a range of other therapeutic targets. This activity, and other factors such as their biological activity, the fact that they are privileged structures, and the presence of the indole …
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Total Synthesis of Apratoxin A Analogues
… cannot be correlated with any of the standard anti-cancer agents in the National Cancer Institute’s library, which suggests a unique mode of action. Herein are reported our efforts towards discovering an apratoxin A analogue that retains its anti-cancer activity, but eliminates its action …
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Synthesis of naphtho{2,3-c}pyrans including the aphin-derived quinone A'
… A and deoxyquinone A for evaluation of their "anti-cancer" activity by the National Institutes of Health. In Chapter Three the final few steps of the synthesis of the aphid-derived quinone A' are described. This was made possible by the development of an efficient route for the conversion of a …
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Effects of modified bioactive pectins on colon cancer cells in vitro
… with pH, heat or enzymes, has been shown to have anti-cancer activity in several cancer cell lines. The galactan chains of MP are postulated to be essential for bioactivity due to their ability to bind and inhibit the pro-metastatic protein galectin-3 (Gal3) on cancer cells. However, the …
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Synthesis and evaluation of novel ellipticines as potential anti-cancer agents
… is a natural product which possesses multimodal anti-cancer activity. This thesis encompasses the synthesis and biological evaluation of novel ellipticine and isoellipticine derivatives as anti-cancer agents. Expanding on previous work within the group utilising vinylmagnesium bromide, …
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Identifying novel drugs for the treatment of rhabdomyosarcoma
… palladacycle, AJ-5, was investigated for its anti-cancer activity and its mechanism(s) of action in RMS cells. The second approach involved a target-based drug repurposing strategy where a library of FDA-approved drugs was screened to identify leads that were able to negatively regulate the …
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Dearomative reduction of arenes through the use of arenophiles & studies towards the synthesis of cardiotonic steroids calotropin and calactin
… is a highly cytotoxic natural product with anti-cancer activity. A total synthesis strategy which utilizes a NHC-catalyzed benzoin condensation, and Pd-catalyzed nucleophilic dearomatization of a phenol is described. Also described, is the semisynthetic strategy towards calotropin from …
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Process development for the extraction of bioactive compounds from endemic South African mushrooms
… water and ethanol. Extracts exhibited selective anti-cancer activity against MDA-MB-231 breast cancer without cytotoxicity to MCF-12A healthy epithelial breast cells, in contrast to doxorubicin, a chemotherapeutic drug. Antioxidant assays revealed high free-radical scavenging capacity, …
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Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer
… reactivates epigenetically silenced genes in cancer, leading to restored tumor suppressor gene expression and cell differentiation, along with activation of endogenous retrovirus (ERV) genes. CDK9 inhibition results in dephorphorylation of the SWI/SNF protein SMARCA4 and represses HP1α …
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Design and Synthesis of Benzimidazoles as CDK5 Inhibitors and Progress toward the Total Synthesis of Tubulysin D
… Tubulysin is a natural product with potential anti-cancer activity. The two gamma-amino acids in the Tuv and Tup fragments of tubulysin were synthesized. Evans' oxazolidinone chemistry was employed for the stereoselective synthesis of Cbz-beta-homovaline in Tuv fragment. A crystal structure of …
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Inflammation enhanced colon cancer & natural anti-cancer plant compounds
… associated with an increased risk for colorectal cancer through mechanisms that are not well understood. Isothiocyanates, which are the bioactive components in broccoli and other cruciferous vegetables, have been shown to suppress COX-2 and IL-6 production from inflammation. The polyacetylene …
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