Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"Anti-bacterial"”.
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New Carbohydrate-Based Anti-Cancer And Anti-Bacterial Vaccines
… expressed on the surface of cancer, bacterial, viral and fungal cells are excellent target antigens for the design of therapeutic or preventive vaccines. However, as antigens carbohydrates have problems. First, carbohydrates usually have low immunogenicity. Second, even if …
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Investigations of Novel Mechanisms of Action for Anti-Bacterial and Anti-Cancer Agent Development
… by the rapid emergence of multi-drug resistant bacterial strains and accumulating mutations in cancer targets that is quickly rendering our current arsenal of drugs ineffective for these therapies. Unless new drugs with novel mechanisms of action are identified and developed at a faster pace, we …
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Inhibition of iron-oxidizing bacteria in wastes from coal and hard-rock mines using the anti-bacterial agent
The production of acid mine drainage (AMD) is catalyzed by iron-oxidizing bacteria primarily of the species Thiobacillus ferrooxidans. By inhibiting these bacteria, the production of AMD can be greatly reduced. One compound found to be effective in the inhibition of T. ferrooxidans is nitrapyrine. …
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Improving Bioactivity and the Anti-Bacterial Properties of Two-Solution Bone Cement Containing Cross-Linked Polymethylmethacrylate (PMMA) Nanospheres (η-TSBC)
… this, recent studies (1-4) have shown that the antibacterial property of hydroxyapatite nanoparticles improved after partial or complete substitution of calcium with strontium ions. The</p> <p>goal of addition of SrHA microspheres into the η-TSBC formulation is to improve bioactivity by allowing …
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Selective therapy with minor groove binders
… of Strathclyde has developed extremely potent anti-bacterial molecules known as minor groove binding agents (MGB) which intrinsic helicity allows binding to the minor groove of DNA. These molecules were effective in vivo, non-toxic and showed activity and selectivity against Gram positive …
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The discovery and functional study of an antimicrobial peptide QUB-1955 from the skin secretion of the northern orange-legged leaf frog, phyllomedusa hypochondrialis
… resistance of bacteria to conventional antibiotics, new antimicrobial drugs need to be discovered urgently. Natural active substances extracted from skin secretions of anurans have attracted much interest in recent years. Among them, anti-bacterial peptides with broad-spectrum …
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Mechanisms of action and inhibition of [4Fe-4S] proteins IspG and IspH in isoprenoid biosynthesis
… biosynthesis is potentially an important anti-bacterial and anti-malarial drug target. However, the catalytic mechanisms of the last two enzymes in this pathway, IspG (also known as GcpE) and IspH (also known as LytB) were largely unknown, and there were no inhibitors targeting these two …
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Functional analysis of Shigella encoded IpaH E3 ubiquitin ligases in cell-autonomous immunity
… mechanisms; amongst them a family of twelve bacterial E3 ubiquitin ligases (IpaH) that are structurally unrelated to eukaryotic enzymes. IpaH ligases are injected into the host cytosol via the bacterial type III secretion system (T3SS) to manipulate the host cell and counteract anti-bacterial …
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Isoprenoid Biosynthesis Pathway as a Drug Target for Bisphosphonates: Transcriptional Profile Investigation
… mechanism of action of novel bisphosphonates as anti-bacterial and anti-cancer agents. We identified a FPPS bisphosphonate inhibitor which in combination with the phosphonate drug fosmidomycin exerted a potent synergistic effect in Escherichia coli. Additionally, we designed novel groups of …
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Experimental and Computational Study of Bisphosphonates Targeting Isoprenoid Biosynthesis Pathway
… bisphosphonates have been found to have anti-cancer, anti-parasitic, anti-bacterial and herbicidal activity. They also have the unexpected property of activating human gammadelta T cells to kill tumor cells. In this work, I used experimental, mainly x-ray crystallography and computational …
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Anti-Adhesive Si-and F-Doped DLC Coatings and Micro-Nanostructured Surfaces for Medical Implants
… coatings and micro-nanostructured surfaces with anti-bacterial properties for biomedical applications. In this study a DLC coating and Si- and F- doped DLC coatings with various Si and F contents were prepared by a radio frequency plasma-enhanced chemical vapor deposition (rf-PECVD) technology. …
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DEVELOPMENT OF SYNTHETIC METHODOLOGIES TOWARDS CYCLIC HYDROXAMIC ACID-BASED NATURAL PRODUCTS
… class of bioactive compounds with wide uses as anti-bacterial, or anti-inflammatory agents and a key component of many natural products, mainly siderophores (low-molecular-weight iron sequestering agents) in lower organisms. Hydroxamic acid based analogs may find potential therapeutic uses in …
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Dissecting the puncturing device of the Type VI Secretion System: role of Hcp, VgrG and PAAR proteins in assembly and secretion of effectors
… role both in direct pathogenicity and in interbacterial interactions, including polymicrobial infections. T6SSs are encoded within large gene clusters containing at least thirteen conserved core components. These form a large trans-envelope machinery, including an expelled puncturing device …
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SYNTHESIS AND BIOLOGICAL EVALUATION OF NATURE-INSPIRED N-HYDROXYPYRIDONES AND THEIR DERIVATIVES
… a range if biological activities, including anti-malarial properties. However, the total synthesis of naturally occurring N-hydroxypyridones and the full scope of the biological activities of these compounds remain largely unexplored. This project commenced with the total synthesis of …
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PHARMACOKINETICS AND ORAL DELIVERY OF POLYMETHOXYLATED FLAVONES
… spectrum of pharmacological activities such as anti-inflammatory, anti-cancer, anti-diabetic, anti-bacterial, anti-fungal, blood thinning and neuro-protective effects have been reported extensively. To further evaluate the medicinal potentials of three polymethylated flavones, namely tangeretin …
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Extraction and Characterization of Xylopic Acid from Xylopia aethiopica
… a plant of Africa, showed various degrees of anti bacterial activity. The activity has been attributed to the presence of Xylopic acid the major diterpene component of the fruit oil extract. This work examines the effects of extraction solvent and time of extraction on the yield of xylopic …
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