Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Anti-apoptosis"”.
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Trabecular Calcium Phosphate Scaffolds for Bone Regeneration
… to controls with a corresponding increase in anti- apoptosis signaling. Similar trends were found with LIPUS stimulation demonstrating that changes in adhesion proteins during attachment may account for the alteration in stress pathways activated by bone precursors. The absence of cell death …
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Chemical Biology Approaches to Interrogate Heat Shock Transcription Factor 1 Regulation in Cancer
… further encompassing critical functions in anti-apoptosis, invasion and metastasis, energy metabolism, DNA damage repair, and evasion of host immune surveillance. Meanwhile, both our understanding of the molecular basis of HSF1 regulation as well as available biochemical tools to investigate …
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Sphingosine-1-Phosphate and Stromal Cells Contribute to an Aggressive Phenotype of Ovarian Cancer
… e.g., proliferation, angiogenesis, inflammation, anti-apoptosis, and others. While S1P's role in the aggressive profile of many other cancers is well defined, its function in ovarian cancer development is less understood. The concentration of S1P is significantly increased in the ascites of women …
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A Structure-Activity Relationship Study with Isoquinolinone Compounds and Stromal Antigen 2 Mutant Ewing’s Sarcoma Cells and Synthesis of Small Molecules for Anticancer Activity Through TEAD Palmitoylation Inhibition
… palmitoylation, in which cell proliferation and anti-apoptosis is prevented. Two small hydrophobic structures were discovered through virtual ligand screening by our collaborators. Two initial synthetic routes were completed to initiate efficient production of products and further advancement in …
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The Role of Wnt3a in Ischemic Stroke
<p>After ischemic stroke, apoptosis of neurons is a primary factor in determining outcome. Wnt3a is a naturally occurring protein that has been shown to have protective effects in the brain for traumatic brain injury. Although wnt3a has been investigated in the phenomena of neurogenesis, …
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Novel Protective Agents against Cerebral Ischemia/Reperfusion Injury.
… neuropeptide against amyloid toxicity, exhibited anti-apoptotic properties on cerebral ischemia injury. HNG reduced infarct volume after ischemia/reperfusion injury with pre-treatment or post-treatment (i.c.v. and i.p.) in a middle cerebral artery occlusion model in mice and decreased neurological …
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Region-Specific Expression of Brain-Derived Neurotrophic Factor (BDNF) mRNA after Long Term Treatment with Lithium Carbonate.
… lateral sclerosis (ALS) by preventing the apoptosis component. In this study, investigation was undertaken to determine if lithium ion would regulate expression of BDNF for its anti-apoptosis action. RT-PCR and fluorescence in situ hybridization experiments were performed to determine the …
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Hsp90 as a molecular target
… to play a role in cell cycle progression, apoptosis, regulates invasion, angiogenesis and metastasis. It is being recognized as a promising target in cancer treatment. Previous studies in our laboratory have demonstrated hsp90α expression in both primary glioma tissue and cell lines, but …
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Stress Conditioning and Heat Shock Protein Manipulation for Bone Tissue Engineering
… shock proteins (HSPs), which are involved in anti-apoptosis, cell proliferation, and differentiation. In vitro stress modulation and HSP induction may be critical factors for enhancing bone regeneration. We investigated whether applying individual or combinatorial stress conditioning (thermal, …
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Design of Peptide Ligands for 14-3-3ε, and Exploring the Role of Residue Types in Ligand Recognition by 14-3-3 Proteins
… isoform is associated with suppression of apoptosis. Like 14-3-3ε, the protein phosphatase cell division cycle 25 A (CDC25A) is over expressed and mislocalized from nucleus to cytoplasm in cSCC. The anti-apoptosis activity of 14-3-3ε is dependent on its interaction with cytoplasmic CDC25A. …
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MOLECULAR DEFECTS OF MEF2 FAMILY PROTEINS AND NAC PROTEINS THAT BLOCK MYOGENESIS AND PROMOTE TUMORIGENESIS IN RHABDOMYOSARCOMA
… patient RMS tumors and depletion of BTF3 induced apoptosis in RMS cells and decrease RMS cell survival. BTF3 depletion also sensitized TRAIL induced cell apoptosis in RMS cells. However, BTF3 played a different role in normal cells. Deletion of BTF3 in C2C12 cells does not induce cell apoptosis, …
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Revealing a Non-canonical Role of Anti-apoptotic MCL-1 in Early Embryonic Development
… indicating a function of MCL-1 beyond regulating apoptosis. Our previous studies revealed an unrecognized role of MCL-1 in promoting mitochondrial physiology, which is independent of its classical anti-apoptotic function and requires being imported into the mitochondrial matrix. In order to …