Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Anti-Tuberculosis Drugs"”.
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Development of novel anti-tuberculosis drugs from African medicinal plants
Includes bibliographical references (leaves 55-63).
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Synthesis of Novel -1, 3, 5 - Triazine - Based - Anti-Tuberculosis Drugs.
… is widely visible in neglected diseases such as tuberculosis, which is an infectious disease caused by bacillus Mycobacterium tuberculosis. The urgent need in search of new biological entities to fight back TB and drug resistant TB is a drive behind this project. Several specific synthetic …
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Simultaneous quantification of first-line anti-tuberculosis drugs and metabolites in human plasma
Tuberculosis (TB) currently kills more people than any other infectious disease worldwide, the highest burden being in Africa and Asia (1). Therapy recommended for drug sensitive TB consists of a cocktail of isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA) and ethambutol (EMB), all given in a …
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The immunopathogenic mechanism of severe cutaneous adverse reactions to first line anti-tuberculosis drugs
… endemic settings like South Africa, first line anti-tuberculosis drugs (FLTD) are the commonest cause of severe immune mediated adverse drug reactions, including Stevens Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS). …
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A study of pharmacokinetics of anti tuberculosis drugs in Zambian PTB patients co-infected with the Human Immuno-Deficiency Virus
… Hospital, Lusaka, Zambia. The assaying of the drugs was done at the University College London Medical School.To determine whether the pharmacokinetics of anti-tuberculosis drugs at steady-state are altered in HIV infected patients especially those with chronic diarrhoea.60 pulmonary …
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A description of the pharmacokinetics of first line anti-tuberculosis drugs and adjunctive corticosteroid therapy in the pericardial compartment and their effect on cytokine profiles in the pericardial compartment of patients with tuberculous pericarditis
… pericarditis is caused by Mycobacterium tuberculosis infection of the pericardium, which is associated with a higher mortality, compared with pulmonary tuberculosis. Constrictive pericarditis, a significant complication of tuberculous pericarditis, contributes to this elevated mortality. …
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Studies of effusive constrictive pericarditis
… mortality rate of 17-40% despite treatment with anti-tuberculosis drugs. The complications of TB pericarditis that confer mortality and morbidity are pericardial tamponade, effusive constrictive pericarditis, and constrictive pericarditis. Whilst the diagnosis and treatment of pericardial …
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Recent advances in drug therapy of tuberculosis
The current medications for tuberculosis treatment could cause a lot side effects, and indirectly lead treatment failure by patient intolerance. Scientists are trying to analyze the gene differences in resistant tuberculosis isolates, find out the reason and later target mechanism could be achieved …
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Characterization and Pharmacokinetics of Rifampicin Laden Carboxymethylcellulose Acetate Butyrate Particles
Tuberculosis, caused by Mycobacterium tuberculosis (MTB), is a common and potentially lethal infectious human disease. Rifampicin is a front line anti-tuberculosis drug usually prescribed in combination with isoniazid, pyrazinamide and streptomycin for a period of six to seven months. When given …
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As causas e consequências da falta de adesão ao tratamento medicamentoso nos casos de tuberculose em Cabedelo-PB.
Tuberculosis is a contagious infectious disease caused primarily by the etiologic agent Mycobacterium tuberculosis or Koch bacillus. Humans harbor the infection of this bacterium as active disease. The lack of adherence to treatment is a major difficulty faced in Brazil and promotes the insistence …
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Genomics study of anti-tuberculosis drug-induced hypersensitivity reactions
Introduction: All first-line anti-tuberculosis drugs can be associated with all phenotypes of cutaneous adverse drug reactions (CADR). Second-line drugs are associated with much poorer outcomes. Thus, identifying the offending drug in poly-pharmacy is difficult. Re -challenge with the drug is the …
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Advancing tuberculosis treatment through pharmacometric modeling of drug exposure and biomarkers
Tuberculosis remains the leading cause of death from a single infectious agent globally, posing a significant threat to public health. This highlights the need for improved treatment strategies to enhance outcomes and limit the emergence of resistance. Optimizing therapy requires more reliable …
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Discovery of novel antibacterial and antitubercular compounds using chemical genetics and computational approach targeted at phospholipid biosynthesis
… provide a basis for the rational design of new antibacterial compounds which will ultimately be developed towards potential new antibiotics. Mounting evidence is implicating the importance of phospholipid in the viability of mycobacteria. The genetically tractable and related organism, …
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Computational approaches to predicting drug induced toxicity
… are presented. Typically, these were based on Quantitative Structure-Activity Relationships (QSAR). The following endpoints were modelled: mutagenicity, carcinogenicity, inhibition of the hERG ion channel and the associated arrhythmia - Torsades de Pointes. A consensus model was developed based …
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Targeting Mycobacterium abscessus Infection in Cystic Fibrosis: A Structure-guided Fragment-based Drug Discovery Approach
… is refractory to treatment with standard anti-tuberculosis drugs and most currently available antibiotics, often resulting in accelerated lung function decline. This project aims to use a structure-guided fragment-based drug discovery approach to develop effective drugs to treat M. …
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Barriers to tuberculosis drug discovery: the mycobacterial cell wall
… that provides intrinsic resistance to several anti-tuberculosis drugs, making it critical in the success of Mycobacterium tuberculosis infection. Multiple layers encapsulate the cell membrane, including arabinogalactan chains and mycolic acids that are covalently bonded to the peptidoglycan …
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The relationship between chest X-ray findings, bacterial load and treatment-related outcomes in persons with extensively drug resistant TB
Multi-drug resistant tuberculosis (MDR-TB) was first recognized in the 1990s with an increase in caseload of eighty-two percent between 2000 and 2007. Extensively drug-resistant tuberculosis (XDR-TB), a more difficult and more expensive form of TB to treat with poorer outcomes, emerged in South …
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Evaluation of the Quality of Artemether/Lumefantrine, Sulphadoxine/Pyrimethamine and Quinine Sulphate Tablets in Public and private Health Institutions in Lusaka District
The problem of counterfeiting of drugs presents an enormous public health challenge. No area of the world is unaffected, but mounting evidence shows that the problem is disproportionately severe in developing and emerging market countries, which also have a high burden of infectious diseases such …
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Evaluation of the Quality of Artemether/Lumefantrine, Sulphadoxine/Pyrimethamine and Quinine Sulphate Tablets in Public and private Health Institutions in Lusaka District
The problem of counterfeiting of drugs presents an enormous public health challenge. No area of the world is unaffected, but mounting evidence shows that the problem is disproportionately severe in developing and emerging market countries, which also have a high burden of infectious diseases such …
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