Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Anti-Toxin"”.
-
Computational Approaches To Anti-Toxin Therapies And Biomarker Identification
… describes the fundamental study of two bacterial toxins with computational methods, the rational design of a potent inhibitor using molecular dynamics, as well as the development of two bioinformatic methods for mining genomic data. </p> <p>Clostridium difficile is an opportunistic bacillus which …
-
CHARACTERIZATION OF DENGUE NEUTRALIZING ANTIBODIES USING RECOMBINANT ANTIBODIES TECHNOLOGY
… EXPLORED THE POTENTIAL OF PASSIVE IMMUNITY AS AN ANTI-TOXIN THERAPY AGAINST TETANUS. THESE PIONEER WORKS LAID THE CORNERSTONES FOR SUBSEQUENT VACCINE AND THERAPEUTIC ANTIBODY DEVELOPMENT AS WELL AS FOR TODAY?S EXPLODING IMMUNOTHERAPY RESEARCH. THE FIRST HALF OF THIS THESIS IS DEDICATED TO THE …
-
Development Of Peptide Inhibitors Targeting Clostridium Difficile Toxins A/b And Characterizing The Regulatory Role Of A Putative Negative Regulator Tcdc In Clostridium Difficile Toxin Gene Expression
… <p>diseases often associated with broad-spectrum antibiotic usage. TcdA and TcdB</p> <p>are the key virulence factors involved in major patho-physiology. While standard</p> <p>antibiotics provide some respite, due to the high relapse rates and the emergence of more</p> <p>severe disease …
-
Identification of Effectors of Synergistic Lethality in Candida albicans-Staphylococcus aureus Polymicrobial Intra-abdominal Infection
… growth. Analyses by qPCR, Western blot, and toxin functional assays confirmed enhanced agr-associated gene transcription and increases in secreted α- and δ-toxins. C. albicans-mediated elevated toxin production and hemolytic activity was determined to be agrA-dependent and genetic knockout …
-
Engineering soluble, high affinity T cell receptor domains for detection of staphylococcal and streptococcal exotoxins
… and group A Streptococcus express a family of exotoxins including staphylococcal enterotoxins A, B, C (SEA, SEB, SEC), toxic shock syndrome toxin-1 (TSST-1) and streptococcal pyrogenic exotoxins (SpeA, SpeC) that possess superantigenic properties, by virtue of which they stimulate a large fraction …
-
Biologically Inspired Engineering for Protein Stabilisation
… work. The aim of the investigation is to quantify the effect of the organic matter on the eggshells which could allow inferring protein incorporation efficiency of different species. The mechanical properties of the eggshells were studied with nanoindentation. This allows probing the …