Global ETD Search
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Showing 1 to 5 of 5 for “"Anti-GD2"”.
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Anti-Gd2 Etoposide-Loaded Immunoliposomes For The Treatment of Gd2 Positive Tumors
… solubility, and off-target effects. Monoclonal antibodies that specifically bind antigens overexpressed on many tumors such as the ganglioside, GD2, can be conjugated to drug-loaded liposomes to create a targeted drug delivery system. In this study, we have encapsulated etoposide, a …
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The Role of Ganglioside GD2 and GD3 Synthase (ST8SIA1) in the Regulation of Immune Suppression in Breast Cancer
… and c series gangliosides, particularly GD3 and GD2, and studies have shown that GD3S is upregulated in most tumors and plays a role in tumor progression. Similarly, we have previously found GD3S to be significantly upregulated in GD2+ breast cancer stem cells (BCSC) compared to GD2- cells, and …
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APPLICATION OF STRUCTURAL, MOLECULAR, AND PROTOEMIC STUDIES TO INVESTIGATE ON-TARGET AND OFF-TARGET MECHANISMS OF LORLATINIB RESISTANCE IN ALK DRIVEN NEUROBLASTOMA
… a common childhood cancer, approval of anti-GD2 immune therapy has improved patient survival and discovery of anaplastic lymphoma kinase (ALK) receptor activating mutations and amplification has provided hope to further increase of patient survival. Despite this success and that of …
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The dynamics of anti-tumour responses generated by chimeric antigen receptor-modified immune effector cells
… and amplified in the laboratory to target antigens expressed on tumour cells through the introduction of chimeric antigen receptor (CAR) genes. Despite considerable advances in the treatment of B cell leukaemia using chimeric antigen receptor T (CART) cells targeting the CD19 antigen, some …
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Precision Cytokine Therapy: Engineering and Delivery of CD8- and CAR-Tropic Interleukin-2 Variants
… generate strong immune responses against foreign antigens. This results from the specialised CNS microenvironment and, in particular, the markedly low numbers of cytotoxic CD8+ T cells present in the brain. This scarcity of CD8+ T cells contributes to uncontrolled tumour progression once …