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Showing 1 to 6 of 6 for “"Anti-DNA antibody"”.
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Characterization of anti-DNA antibody with Tat peptide sequence in CDR
"Tat 펩티드가 삽입된 항-DNA 항체 구조의 생화학적 특성 항-DNA 항체인 3D8 단일 가닥 가변부위 (single chain variable fragment: scFv)는 핵산결합능 및 가수분해활성이 있으며, 3D8 VL 단독부위만으로도 핵산 결합능 및 가수분해능을 발휘한다. 또한 3D8 scFv는 세포막 침투능이 있어서, 세포막을 투과한 후, 세포질에 위치하게 되고, 결국은 세포사멸을 유도한다고 알려져 있다. 본 연구에서는 3D8 scFv의 핵산가수분해 활성은 그대로 유지하면서, 세포막 투과 후 핵으로 이동할 수 있는 …
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Generation of chickenized 3D8 scFv antibody from mouse monoclonal anti-DNA antibody by CDRs-grafting
… derived from a MRL-lpr/lpr mouse is a catalyric anti nucleic acid antibody that has ability of cellular internalization and DNA/RNA-hydrolyzing activity. It has been reported that cells treated with 3D8 scFv protein showed the down-regulation against replication of RNA-genomed viruses and this …
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Characterization of Anti-Dna Antibody Purified From Sera of Patients With the Autoimmune Disease Systemic Lupus Erythematosus
Made available in DSpace on 2014-12-11T18:16:58Z (GMT). No. of bitstreams: 1 7514140.pdf: 6330150 bytes, checksum: 186f6d46446050cc341de0aa6d50f312 (MD5) Previous issue date: 1975
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Specificity of Anti-Dna Antibodies in Systemic Lupus Erythematosus
In an effort to clarify the involvement of anti-DNA antibodies in the disease systemic lupus erythematosus (SLE), the specificity of naturally occuring anti-DNA antibody in plasma of human patients with SLE was studied in detail.
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Suppressive effect of a nucleic acid-hydrolyzing recombinant antibody (3D8) on viral multiplication
… chain variable fragment (scFv) is a recombinant anti-DNA antibody from an autoimmune-prone MRL-lpr/lpr mouse with lupus diseases. 3D8 scFv can hydrolyze ss-DNA, ds-DNA, ss-RNA, and ds-RNA without sequence specificity. On the base of 3D8 scFv property, we carried out quantitative and qualitative …
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Studies on the efficient intracellular delivery vehicle using variable region domain of a cell-penetrating anti-DNA monoclonal antibody
The cell-penetrating antibodies and antibody fragments can be utilized as a tool for the medical diagnosis and treatment. In this study, we have produced the protein of recombinant VH domain of a monoclonal anti-DNA antibody 2C10, IgG of which has been previously shown to have cell-penetrating …