Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Anti-Bacterial agents"”.
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Studies on the ecology of Staphylocococcus Aureus and the epidemiology of Staphylococcal infections
… of Staphylococcus aureus to adapt itself to anti¬ bacterial agents which have been introduced for its control. There is need therefore for a detailed investigation of the sources, routes and modes of spread of staphylococcal infection and the part played by antibiotics in their epidemiology.
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Total Synthesis of Marine Macrolide Mangrolide D
… Although mangrolide D did not register the antibiotic activity, this convergent and efficient synthetic route still facilitates future synthesis of mangrolide analogues as well as other structurally similar macrolides, like fidaxomicin and its analogues, for the purpose of new drug discovery.
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Mangrolide A, A Novel Marine Derived Polyketide with Selective Antibiotic Activity
… combat infections caused by pathogenic bacteria. Antibiotic resistance is a major challenge faced in hospitals today, and there is an urgent need for new antibiotics. The "Golden Age" of antibiotic development was spurred by compounds isolated from terrestrial bacteria. Unfortunately, the rate of …
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The Synthesis of Amphiphilic Glycolipids as Potential Inhibitors of Bacterial Adhesion
The synthesis of glycolipids as potential anti-bacterial agents and glycolipid mimetics is the main focus of the research presented in this thesis. A variety of glycolipids based around an aspartic acid, aliphatic or aromatic scaffold were investigated. Chapter 1 describes the biological importance …
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The Effect of Antibiotic Prophylaxis on Infection Rates in Mohs Micrographic Surgery: A Single-institution Retrospective Study
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Non-Invasive Eradication of Biofilm on Metal Implants Using Alternating Magnetic Fields (AMF) and Antibiotics
… are difficult to treat with conventional antibiotics due to the formation of biofilm on the implant surface. Our group is developing a non-invasive method to eliminate biofilm on metal implants using alternating magnetic fields (AMF), utilizing the physical principle of electromagnetic …
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Total Synthesis of Mangrolide A
The discovery of antibiotics in the 1930s played a critical role in human health by treatment of patients with kinds of infections. During the 'golden era' of antibiotic research, various antibiotics were discovered. The emergence of multi-drug-resistant bacteria has jeopardized the human health. …
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Characterization of Mycobacterium tuberculosis Cor, a Protein Essential for Carbon Monoxide Resistance and Pathogenesis
Pages 1-101 of the dissertation are incorrectly numbered as pages 2-102.
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Studies Toward the Syntheses of Antiarrythmic, Anti-Virulence, and Anticancer Small Molecules
… of three projects: a) the development of antiarrythmic analogs of 17(R),18(S)-epoxyeicosatetraenoic acid for the treatment of atrial fibrillation, b) the development of potent inhibitors of QseC mediated virulence gene expression, and c) studies toward a biomimetic total synthesis of …
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The Biological Burden of Antibiotic Resistance in Staphylococcus aureus
<p>Antibiotic resistance is a major problem. Resistance is often mediated by genes on bacterial plasmids and dissemination of resistance is commonly achieved by plasmid transfer. The mechanisms of resistance that are presently understood suggest that resistance is energetically costly. If this is …
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The Invisible Force: Optimizing Novel Approaches in Anesthesiology and Infectious Diseases
… 3s pulses for 15, 30, or 60 minutes to reduce bacterial load. Combined treatment with AMF and ceftriaxone (or linezolid) showed a 5-log decrease in bacterial load after 24 hours, whereas singular treatment with AMF or abx alone showed total regrowth or moderate decrease in bacterial load …
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Investigations of Novel Mechanisms of Action for Anti-Bacterial and Anti-Cancer Agent Development
The development of drugs and therapeutic agents for combating infections and human malignancies continues to be a forefront area in both academic and industrial research. This is driven by the rapid emergence of multi-drug resistant bacterial strains and accumulating mutations in cancer targets …