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Showing 1 to 20 of 34 for “"Anthraquinones"”.
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Synthesis, DNA interactions and activation of novel cytotoxic anthraquinones.
… and related bis-substituted alkylaminoanthraquinones was undertaken with a view to developing agents with reduced toxicity to normal cells. DNA intercalation was evaluated using spectrophotometric and DNA thermal denaturation (Tm) techniques with calf thymus DNA. Overall, compounds that …
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Reactions of various aromatic nitro-compounds and anthraquinones with selected bases and nucleophiles
… N-methyl acridones and (ii) treatment of chloro-anthraquinones with fo rmamide and a new synthesis of chloro-anthracenes . 5-Chloro-1 -N-methylaminoanthraqui none was synthesised f rom 1,5-dichloroanthraquinone by treatment with N-methylformamide. Treatment of …
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Genetic transformation of Ceratotheca triloba for the production of anthraquinones from hairy root cultures
Submitted in complete fulfilment for the Degree of Master of Technology: Biotechnology, Durban University of Technology, Durban, South Africa, 2012.
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SYNTHETIC AND MECHANISTIC PHOTOCHEMISTRY OF ALKOXY ANTHRAQUINONES: POTENTIAL UTILITY IN DRUG DELIVERY AND SYNTHETIC METHODOLOGIES
… details of the photochemical reactions of alkoxy-anthraquinones in various media in order to devise potential applications of these photoreactions. Currently, Photodynamic therapy relies on the generation of singlet oxygen in cells which is not efficient under hypoxic conditions such as that in …
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Elucidation of Reactions in Organic Photochemistry
… is unavailable in the ground state. 1,2-Dialkoxy anthraquinones exhibit photochemistry which releases an alkane functional group from the 1-position and forms a dimer from the anthraquinone moiety. This reactivity is observed for a plethora of 1,2-dialkoxy-9,10-anthraquinones; however different …
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PHOTOCHEMICAL HYDROXYLATION OF 1-METHYLANTHRAQUINONES: SYNTHESIS OF 9`-HYDROXYALOESAPONARIN II
Triplet excited 9,10-anthraquinones can abstract H from alkyl groups ortho to the carbonyl. The hydrogen transfer results in a 1,x biradical which then undergoes a variety of reactions. One of these, oxidation of an alkyl substituent ortho to one of the carbonyls, was believed to go through …
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Sonogashira coupling reactions in the synthesis of near infra-red emitters and of star systems for the study of charge propagation in dendrimers
… functional systems: arylethynyl-substituted 9,10-anthraquinones, Os(II) bis(2,2'-bipyridine) (3,8-diarylethynyl-1,10-phenanthroline) complexes and four star-shaped molecules incorporating the 4-benzoyl-N-alkylpyridinium cation."--Abstract, page iv.
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Synthesis, characterisation and application of novel quinones for the detection of latent fingermarks
… between benzoquinones, naphthoquinones and anthraquinones as they differ only by π conjugation. Another aim of this thesis was to synthesise a variety of quinones with differences in conjugation and substitution in order to compare and determine differences in quantum yield and whether these …
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PHOTOLYSIS OF1-METHYL-9,10-ANTHRAQUINONE DERIVATIVES AND THEIR POTENTIAL REACTIVITY IN THE PHOTOENOL DIELS-ALDER REACTION
Functionalized 9,10-anthraquinones (AQ) have proven to undergo a Photoenol Diels-Alder (PEDA) reaction. The PEDA reaction has been enhanced by the following factors: increased AQ electron density and the geometry of the intermediate 1,4-biradical (BR). Hydrogen bonding of the intermediate BR aids …
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Isolation, Synthesis and Structure-Activity Relationship Study of Anticancer and Antimalarial Agents from Natural Products
… (Asparagaceae); and two new antiplasmodial anthraquinones from Kniphofia ensifolia (Asphodelaceae). The structures of all these compounds were determined by analysis of their mass spectrometric, 1D and 2D NMR, UV and IR spectroscopic and optical rotation data. Other than structural …
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Evaluation of indigenous Namibian mushrooms and plants for antimalarial properties
… of phytochemical profiles (saponins, terpenoids, anthraquinones, coumarins, alkaloids, and flavonoids) using standard procedures; elucidation of active antiplasmodial compounds using Gas chromatography-Mass Spectrometry (GC-MS), Fourier Transform Infrared (FTIR) and Nuclear Magnetic Resonance …
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Mechanistic insights into the direct synthesis of H2O2 on transition metal catalysts
… oxidants such as Cl2. The auto-oxidation of anthraquinones is the current standard for industrial H2O2 production, however, this process requires significant energy input due to the extensive purification and concentration processes involved, making H2O2 cost-prohibitive for many oxidation …
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In vitro anti-platelet aggregation activity of the extracts of bulbine natalensis
… Phytochemical screening revealed the presence of anthraquinones, cardiac glycosides, saponins, tannins, flavonoids and alkaloids. The hexane extract revealed the highest contents of total phenols (5.028 mg/g); flavonoid (3.293 mg/g) and proanthocyanidin (2.565 mg/g). Hexane extract also displayed …
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Surface enhanced resonance Raman spectroscopy of dyes: semi-quantitative trace analysis
… differentiate between two structurally similar anthraquinones, alizarin and purpurin, using SERRS. It was also possible to demonstrate the existence of multiple molecular species of certain dye molecules, as a function of pH e.g. nuclear fast red, metanil yellow, purpurin and alizarin. For some …
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Development of a TSM Biosensor for the Determination of DNA- Drug Interactions: A Novel Method to Assist Drug Development
… binding. These were mitoxantrone. and two other anthraquinones, which exhibit intercalation and surface binding; bisbenzamide that exhibits groo\e binding, and cisplatin that forms cross-links with DNA. Measurement of the resonant frequency of the coated DNA sensors gave comparative binding …
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Ethnobotanical and ethnopharmacological documentation of antimalarial plants used by the Jakun community in Kg Peta, Endau-Rompin, Johor, Malaysia
… i.e., alkaloids, flavonoids, terpenoids and anthraquinones using thin-layer chromatography (TLC). Results revealed the presence of at least one of the phytochemical class in each extracts. Extracts were subjected to antiplasmodial activity through histidine-rich protein II (HRP2) assay …
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Antibacterial, antioxidant and phytochemical investigation of Acacia Arenaria, Aloe Esculenta and Pechuel-Loeschea Leubnitziae
… of steroids, terpenoids, saponins, flavonoids, anthraquinones, coumarins, alkaloids, phenols and tannins. The results obtained in the present study indicated that the leaves, stem and roots of A. esculenta, and A. arenaria, P. leubnitziae are potential sources of natural antioxidants and …
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Anthraquinone-peptide conjugates as inhibitors of DNA transcription factor binding.
… of proteins were attached to mono-substituted anthraquinones through various amino acid type linkers. It was envisaged that these intercalator-linked peptides would have the advantage of high DNA binding with some sequence selectivity. The peptides (l:ARCKA; 2:AKCRA; 3:AKSRA; 4:AKCRNA; …
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