Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"Anthracycline"”.
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The genetics of anthracycline-induced cardiotoxicity in cancer patients
… to early diagnosis and advances in treatment. Anthracycline-based chemotherapy is a relatively low cost yet highly effective anti-cancer treatment, increasing survival from 30% to >80%, presently. However, treatment efficacy is marred by the increased risk of anthracycline-induced …
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Investigation of anthracycline based topoisomerase II inhibitors in triple negative breast cancer
Triple negative breast cancer (TNBC) constitutes10-20% of all breast cancer (BCa) cases. TNBC remains unresponsive to targeted therapy, and primarily relies on chemotherapy for treatment. Mitoxantrone (MTX), a topoisomerase II inhibitor belonging to the anthracenedione class, is used in BCa …
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CARDIOVASCULAR RESPONSES TO ACUTE EXERCISE IN ANTHRACYCLINE TREATED CANCER SURVIVORS AND HEALTHY CONTROLS
… cardiotoxicity is a known consequence of anthracycline-based chemotherapy, its relationship to exercise intolerance has not been elucidated. PURPOSE: the objective of this study was to compare cardiovascular responses, at rest and peak exercise, in anthracycline treated cancer survivors …
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Detecting subclinical anthracycline therapy related cardiac dysfunction in low income country (SATRACD study)
Introduction: Anthracycline therapy-related cardiac dysfunction (ATRCD) is the most common chemotherapy-induced cardiovascular toxicity. It begins with subclinical myocardial cell injury that can be detected using speckle tracking echocardiography (STE), together with Troponin-I. Limited …
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Predictive factors of stable or progressive disease during anthracycline with/without taxane-based neoadjuvant chemotherapy in breast cancer
… stable (SD) or progressive disease (PD) during anthracycline with/without taxane based NAC. Methods: From January 2012 to December 2015, data were collected retrospectively by reviewing medical records of patients who received NAC. Statistical analysis was performed to compare patients with a …
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Optimization of Optical Nanosensor Response for the Detection of Anthracyclines Using a Binary Machine Learning Classifier
… drugs makes dose selection of chemotherapeutic anthracyclines difficult. One potential solution to determining dosing levels of an anthracycline is the development of non-invasive sensors to monitor their pharmacology in vivo. Single-walled carbon nanotubes (SWCNT) have substantial potential for …
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Assessment of Myocardial Fibrosis using Cardiovascular Magnetic Resonance Extracellular Volume Mapping in Cancer Patients Treated with Anthracycline-based Chemotherapy Compared with Untreated Cancer Patients and Cancer-free Peers
In this thesis, we will evaluate the effect of anthracycline chemotherapy on measures of myocardial injury and fibrosis using quantitative cardiovascular magnetic resonance (CMR) imaging techniques. Anthracycline-based chemotherapy regimens are often an essential component of curative cancer …
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Prevention of cancer therapy related cardiotoxicity: A Tayside Pharmaco-Epidemiology study (PROTECT-TAYSIDE study)
… of these drugs. Cytotoxic antibiotics such as anthracyclines and the monoclonal antibody trastuzamab are both commonly used in breast cancer and may cause irreversible cardiotoxicity, though trastuzumab-induced damage can be reversed upon stopping. Various animal studies have shown that …
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Interactions of Anticancer Drugs With DNA Studied by High-Resolution NMR Spectroscopy
The anthracycline daunorubicin has been widely used to treat acute leukemia clinically. The newly designed bisanthracycline bisintercalator WP631 has shown promising results against the anthracycline resistance that is due to the transport proteins, e.g., P-glycoprotein. The 3D structures of 1:1 …
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High-resolution NMR spectroscopic analysis of anticancer drugs, DNA and their interactions: 1. Platinum anticancer compounds - DNA interactions. 2. Anthracycline drugs - DNA interactions and modified DNA
Chemotherapy with anticancer drugs is one of the main method of cancer treatment. The exploitation of the stereochemical interactions between anticancer drugs and DNA is of great importance for the ultimate clinical advances of cancer chemotherapy, which needs the detailed structural knowledge of …
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Mechanisms of multidrug resistance in bladder cancer: the role of the nuclear membrane
… using mitomycin C or epirubicin (an anthracycline), following<br/>surgical resection. However, despite this treatment, the recurrence rates of<br/>these tumours can approach 60%. This high recurrence rate represents the<br/>development of MDR in many cases.<br/><br/>Previous work …
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Dearomative hydroboration-enabled synthesis of idarubicinone and synthesis of minor cannabinoids and their metabolites
Anthracyclines are archetypal representatives of tetracyclic type II polyketide natural products that are widely used in cancer chemotherapy. Although syntheses of this class of compounds have been extensively explored, all known approaches are based on annulations, relying on the union of properly …
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THE NOVEL GEMCITABINE PHOSPHOLIPID CONJUGATE KPC34 HAS ACTIVITY AGAINST MULTIPLE MODELS OF RESISTANT ACUTE LYMPHOBLASTIC LEUKEMIA
… both types of disease involve cytarabine and an anthracycline. After initially responding to treatment, most patients eventually relapse with disease that is resistant to conventional modalities. There is a pressing need for novel therapeutic agents to treat the acute leukemias, especially in the …
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Development of novel extraction and separation methods for the determination of anthracyclines and taxanes simultaneously from biological matrices
… patients may be given a combination of an anthracycline and a taxane for chemotherapy treatment. Despite the fact that a mixture of anthracyclines and taxanes may be administered simultaneously to patients and that accurate measurement of drug levels during chemotherapy is proven to be more …
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Early Identification of Chemotherapy Induced Cardiotoxicity Using Structural and Functional Cardiovascular MRI
Anthracycline chemotherapies induce nonfocal cardiac injury to the left ventricular (LV) myocardium. This damage, chemotherapy induced cardiotoxicity, is difficult to detect noninvasively prior to the advancement of injury to an irreversible state with decrements in left ventricular ejection …
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Prognostic Markers and Mechanisms of Chemotherapy Resistance in Diffuse Large B-cell Lymphoma
… impact after the addition of rituximab to anthracycline-based chemotherapy. Results showed better prognosis in CD40-positive patients receiving this combined treatment. An inflammatory stromal process was observed in CD40-expressing tumours when using gene expression profiling, possibly …
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Antioxidant pathways and human leukaemia chemotherapeutic sensitivity
… of the antimetabolite cytarabine (ara-C) and the anthracycline cytotoxic antibiotic daunorubicin (DNR). The cytoprotective gene haem oxygenase-1 (HO-1) has been found regulated in various forms of cancers (including AML) and implicated in chemotherapeutic drug-resistance. HO-1 protects AML cells …
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Role of Manganese Superoxide Dismutase in Chemotherapy-induced Oxidative Stress
… from lymphoma patients receiving standard anthracycline-based therapies, identified single nucleotide polymorphisms in oxidative stressrelated genes associated with survival. Individuals carrying minor allele SNPs in myeloperoxidase (MPO) and an aldo-keto reductase (AKR1C3) were found to be …
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