Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"Anthelmintics"”.
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The Effects of Treating Dauer C. Elegans with Natural Anthelmintics and Ivermectin
… of this thesis is to verify the effectiveness of anthelmintics during arrested development. Anthelmintics are any drug that aims to treat parasitic infections without harming the victim. The experiment performed focused on two strains of Caenorhabditis elegans, a wild and mutant strain. They were …
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Evaluation of Long-Acting Eprinomectin Compared to Conventional Anthelmintics in Cow/Calf Production
<p>Experiment 1, 83, newly weaned, fall-born crossbred heifer calves were allocated randomly to 1 of 3 anthelmintic treatments: 1) control (CON); 2) combination pour-on moxidectin and oxfendazole (MO); and 3) long-acting eprinomectin (LAE). Two preplanned orthogonal contrast statements were used: …
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The efficacy of three candidate anthelmintics against adults and pre-adults of Heterakis gallinarum and Ascaridia galli of chickens
Digitized by Kansas State University Libraries
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The Pharmacological Characterization of Hco-UNC-49, a GABA-gated Chloride Channel from the Parasitic Nematode Haemonchus contortus
… for Cel-UNC-49. Novel effects of a number of anthelmintics were also observed. For example, the anthelmintics ivermectin and moxidectin both enhanced Hco-UNC-49 GABA responses, while piperazine was able to directly activate Hco-UNC-49 at high concentrations. These results suggest that …
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Chemogenomic approaches to drug design : docking-based virtual screening of nematode GPCRs for potential anthelmintic agents
… the animal populations. However, the current anthelmintics are no longer as effective and some strains have developed resistance thus increasing the need for new anthelmintics. Unfortunately, not too much information is available detailing the physiology of helminths. The published genomic …
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In-vitro analysis of microfilariae phenotypic responses induced by small molecules and dsRNA targeting receptor pathways
… Current methods of control include a range of anthelmintics. However, with resistance on the rise, drug target discovery and development are urgently needed. This study explores phenotypic responses in microfilariae to small molecules as well as dsRNA molecules targeting genes involved in …
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Novel Approaches for Anthelmintic and Nematicide Discovery
… The development of genetic resistance to anthelmintics and the phase-out of effective nematicides due to environmental toxicity and human safety concerns necessitates the discovery of new chemical controls for parasitic nematodes with novel targets and modes-of-action. The free-living …
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The effects of extended-release eprinomectin on heifer performance and fescue toxicity and an evaluation of parasite resistance
Anthelmintics are commonly used by livestock producers. Parasite resistance has been reported in ruminants in multiple macrocyclic lactones, after their use over time. As new versions of anthelmintics are released to the market, evaluations for resistance need to be conducted. In addition, the use …
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Anthelmintic Screening, Phytochemical Analysis and Cytotoxicity Determination of the Indigenous Plants of the U.S.A. Northern Great Plains
… of anthelmintic resistance with the overuse of anthelmintics has created a greater need to look for the alternative source for anthelmintics. Therefore, this thesis focuses on evaluating medicinal plants from the USA Northern Great Plains for anthelmintic activity against <em>H. contortus</em>. …
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An investigation into the mode of action of the anthelmintic emodepside: a molecular, pharmacological and electrophysiological characterisation
Resistance to anthelmintics is increasingly becoming a problem for the agricultural industry. Emodepside is a novel anthelmintic that is effective against a variety of parasitic nematodes in which resistance to other anthelmintics has developed (Harder and Samson-Himmelstjerna, 2002). This suggests …
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Investigation into the role of binding loop E on the function of the nematode cys-loop GABA receptor.
… that could be exploited in the design of novel anthelmintics.
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An examination of interacting residues in the GABA-gated ion channel UNC-49 within the parasitic nematode Haemonchus contortus
… be utilized for the future development of new anthelmintics to combat the increasing prevalence of infection by H. contortus.
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The anthelmintic effect of Bacillus thuringiensis Cry5B on Haemonchus contortus in sheep
… an urgent need for alternatives to commercial anthelmintics. The bacterium Bacillus thuringiensis (Bt) can produce crystal proteins during sporulation, which can be lethal to insects in multiple orders when ingested. One protein, Cry5B, has demonstrated effectiveness against multiple parasitic …
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The Effects of Naturally Occurring Plant Products on Experimental Haemonchus contortus Infection in Gerbils and Sheep
… worldwide. Widespread resistance to commercial anthelmintics has created a need for alternative methods of parasite control. One method involves using plant products with natural anthelmintic properties. This thesis assessed the efficacy of several plant products against experimental Haemonchus …
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Examination of intramolecular interactions between residues of the cys-loop GABA receptor Hco-UNC-49 from Haemonchus contortus
… that may be vital for the creation of new anthelmintics.
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Isolation and partial characterization of three acetylcholine-gated chloride channels in Haemonchus contortus
… rise in resistance seen worldwide to existing anthelmintics, novel drug targets must be identified so new treatments can be developed. This thesis describes the identification of three acetylcholine-gated chloride channelss (hco-acc-1, hco-acc-2, and hco-acc-4) genes from the nematode parasite …
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Stability evaluation of selected anthelmintic macrocyclic lactone compounds and formulations
… oxime and moxidectin) are among most important anthelmintics, used extensively and globally. However, excessive and uncontrolled use of MLs and other anthelmintic classes in the last two decades has resulted in a global anthelmintic resistance problem. Given the lack of new molecules, …
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Interactions and epidemiology of nematode worm control in livestock
The livestock industry relies heavily upon anthelmintics for the treatment of parasitic nematode diseases. This has resulted in widespread resistance to multiple anthelmintic classes across several parasitic genera. In response to this spread in resistance and subsequent decrease in efficacy there …
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Transcriptomic and proteomic analysis of Ascaris suum larvae during their hepato-tracheal migration
… ascariasis is controlled by mass treatment with anthelmintics. However, due to the short activity of the anthelmintics and an environment often highly contaminated with Ascaris eggs, reinfections can occur rapidly. In addition, the development of anthelmintic resistance which has been observed in …
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