Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Anthelmintic resistance"”.
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Experimental design and mathematical modelling methods for the study of anthelmintic resistance in UK livestock populations
… widely used field based method for estimating anthelmintic efficacy and as an indicator of anthelmintic resistant nematodes in cattle. In this thesis, statistical aspects such as the analysis of cattle faecal egg count (FEC) data and the identification of statistically robust experimental study …
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Investigation into potential Dirofilaria immitis drug targets through rational anthelmintic synthesis and design
… due to several factors including climate change. Anthelmintic resistance is becoming increasingly problematic and as such, the aim of this thesis was to synthesize several novel compounds and examine their activity on the anthelmintic receptor targets of interest, ACC-2 which is an …
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The identification of novel cys-loop receptor genes in Dirofilaria immitis
… drug class – the macrocyclic lactones – but anthelmintic resistance is emerging. Cys-loop ligand-gated ion channels are an untapped source for drug targets essential for nematode neurotransmission. This thesis presents the isolation and preliminary pharmacological characterization of three …
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The anthelmintic effect of Bacillus thuringiensis Cry5B on Haemonchus contortus in sheep
Widespread anthelmintic resistance in trichostrongyle nematodes of ruminants has created an urgent need for alternatives to commercial anthelmintics. The bacterium Bacillus thuringiensis (Bt) can produce crystal proteins during sporulation, which can be lethal to insects in multiple orders when …
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Stability evaluation of selected anthelmintic macrocyclic lactone compounds and formulations
… and subtropical human populations. Various anthelmintic drugs and their preparations are used for control of these parasites. Macrocyclic lactone (ML) compounds such as avermectins (e.g. abamectin, ivermectin, eprinomectin) and milbemycins (e.g. milbemycin oxime and moxidectin) are among …
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Systems based approaches to unravelling neuropeptide-receptor interactions in nematodes
… in livestock and crop farming. The escalation of anthelmintic resistance in economically important nematode parasites underscores the need for the identification of novel drug targets in these worms. Neuropeptide G protein-coupled receptors (NP-GPCRs) are an appealing anthelmintic target, however, …
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The Search for Novel Anthelmintic Targets: Characterizing Alternative Metabolic Pathways in Caenorhabditis elegans
… on the agricultural industry. Unfortunately anthelmintic resistance is a growing problem. Helminths survive long periods of low to no oxygen in their hosts, but their anaerobic metabolism has yet to be fully characterized. The goal of this project has been to characterize the anaerobic …
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Anthelmintic Screening, Phytochemical Analysis and Cytotoxicity Determination of the Indigenous Plants of the U.S.A. Northern Great Plains
… conventional anthelminthics. The appearance of anthelmintic resistance with the overuse of anthelmintics has created a greater need to look for the alternative source for anthelmintics. Therefore, this thesis focuses on evaluating medicinal plants from the USA Northern Great Plains for …
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The effect of application of the FAMACHA© system on selected production parameters in sheep
… resulted in an economic loss due to the cost of anthelmintic when compared to using the FAMACHA© system. A shortage of feed due to unseasonal downpours leading to poor Body Condition Scores (BCS), forced the farmer to supplement the grazing and the FMCH group was able to make use of compensatory …
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Characterization of the ACC-1 Family of cys-loop ligand gated ion channels from the parasitic nematode Haemonchus contortus.
… for decades because of their role in current anthelmintic action and potential as targets for future drugs. Many families of cys loop receptors have not yet been pharmacologically characterized in parasitic nematodes, and thus provides an opportunity for further exploration into their role in …
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The effects of extended-release eprinomectin on heifer performance and fescue toxicity and an evaluation of parasite resistance
Anthelmintics are commonly used by livestock producers. Parasite resistance has been reported in ruminants in multiple macrocyclic lactones, after their use over time. As new versions of anthelmintics are released to the market, evaluations for resistance need to be conducted. In addition, the use …
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Software-based decision-support : a basis for the development of a predictive system for sustainable management of haemonchosis in small ruminants
… addressed in the development of a wider ranging anthelmintic treatment decision-support system to delay anthelmintic resistance. The application of important quantitative methods, such as two-graph Receiver Operating Characteristic analysis, Monte Carlo simulation, and Shannon’s entropy to the …
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Transcriptomic and proteomic analysis of Ascaris suum larvae during their hepato-tracheal migration
… ascariasis is controlled by mass treatment with anthelmintics. However, due to the short activity of the anthelmintics and an environment often highly contaminated with Ascaris eggs, reinfections can occur rapidly. In addition, the development of anthelmintic resistance which has been observed in …
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EPIDEMIOLOGY AND DISTRIBUTION OF PARASITES OF ANIMAL - SPECIFIC AND ZOONOTIC IMPORTANCE IN PIG FARMS IN NORTHERN ITALY.
… environment. Given the growing concern about the anthelmintic resistance, an effective approach requires an integrated strategy that combines pharmacological interventions with optimized management practices. The review of the scientific literature revealed several gaps in the epidemiology of …